The regulation and role of osteopontin in malignant transformation and cancer

El‐Tanani, Mohamed; Campbell, Frederick Charles; Kurisetty, Vittal; Jin, Dachuan; McCann, Mella; Rudland, Philip S.

doi:10.1016/j.cytogfr.2006.09.010

Cited by 156 publications

(157 citation statements)

References 59 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…The potential impact (if any) of OPN on the CNS and PNS to affect balance and coordination likely involve both positive and negative effects. At the cellular level, the protein has proadhesive, chemotactic and cytokine-like properties, and is involved in a number of physiologic and pathologic events including angiogenesis, apoptosis, inflammation, oxidative stress, remyelination, wound healing, bone remodeling, cell migration and tumorigenesis (Chakraborty et al 2006;El-Tanani et al 2006;Pagano and Haurani 2006). As some of these events lead to neurodegeneration (Maetzler et al 2007;Wung et al 2007) whereas others to neuroprotection (Meller et al 2005;Schroeter et al 2006), the overall outcome in sensorimotor neurons may have been neutralized in the null deletion.…”

Section: Discussionmentioning

confidence: 99%

Osteopontin is not Critical for Otoconia Formation or Balance Function

Zhao

Jones

Thoreson

et al. 2008

JARO

View full text Add to dashboard Cite

Unlike the structural and mechanical role of bone crystals, the inertial mass of otoconia crystals provides a shearing force to stimulate the mechanoreceptors of the utricle and saccule (the gravity receptor organ) under the stimuli of linear motion. It is not clear whether otoconia, composed primarily of CaCO 3 and glycoproteins, go through similar calcification processes as bone. We have recently shown that otoconin-90 (Oc90) regulates the growth of otoconia crystals as osteopontin does bone crystals. Here, we analyzed the role of this non-collagenous bone matrix protein, osteopontin, in otoconia formation and balance function utilizing its knockout mice, whose inner ear phenotype has not been examined. Despite the presence of the protein in wild-type otoconia and vestibular hair cells, morphological, ultrastructural, and protein and calcium composition analyses of osteopontin null otoconia show that the protein is not needed for crystal formation, and no evidence of compensatory protein deposition is found. Employment of a wide spectrum of balance behavioral tests demonstrates that the protein is not critical for balance function either, which is confirmed by the normal function of the gravity receptor organ directly measured with linear vestibular-evoked potentials (VsEPs). When compared with findings on other otoconins, the data manifest a hierarchy of importance of proteins in crystallization and indicate mechanistic similarities and differences between bone and otoconia calcification.

show abstract

Section: Discussionmentioning

confidence: 99%

Osteopontin is not Critical for Otoconia Formation or Balance Function

Zhao

Jones

Thoreson

et al. 2008

JARO

View full text Add to dashboard Cite

show abstract

“…Its promoter is responsive to a number of different transcription factors El-Tanani et al, 2006). With the exception of functionally important cleavage products and occasional splice variants, full-length OPN is composed of some 300 amino acids (297 in mouse; 314 in human).…”

Section: Structure and Function Of Osteopontinmentioning

confidence: 99%

“…It was originally identified as a bone matrix protein and subsequently identified as a cytokine (Eta-1) produced by activated T cells and transformed cell lines (Patarca et al, 1993;Sodek et al, 2000;. Receptors for OPN include certain integrins Yokasaki et al, 2005;El-Tanani et al, 2006) and CD44 variants (Weber et al, 1996;Katagiri et al, 1999;Sodek et al, 2006). These receptors mediate cell adhesion, migration and cell survival in a variety of cell types.…”

Section: Introductionmentioning

confidence: 99%

Osteopontin: Role in immune regulation and stress responses

Wang¹,

Denhardt²

2008

Cytokine & Growth Factor Reviews

609

558

View full text Add to dashboard Cite

“…It is a key molecule in neoplastic transformation and cancer development in a variety of tumors, including breast, skin, and ovary. 72 OPN levels in plasma and cerebrospinal fluid were found to be elevated in patients with atypical teratoid/rhabdoid tumors. 73 Tumor progression is facilitated by degradation or remodeling of the extracellular matrix.…”

Section: Identification Of Proteins Known To Be Associated With Cancersmentioning

confidence: 99%