The regulation of a variability of somatic mammalian cell genome under the influence of exogeneous biological factors

Лукаш, Л. Л.

doi:10.7124/bc.000697

Cited by 9 publications

(6 citation statements)

References 42 publications

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“…Chromatid aberrations are assumed to be related to disturbances in the process of break reparation in double stranded DNA [19]. Chromatid breaks and fragments are the most frequent types of chromosomal aberrations caused by various infectious agents, including aden oviruses, simple herpes viruses, influenza viruses, tick borne encephalitis, measles, and some bacteriamycoplasma, shigella, and salmonella [3][4][5][6][7][8].…”

Section: Resultsmentioning

confidence: 99%

“…From the 1960s, it has become obvi ous that viruses might be capable of inducing various aberrations in the nuclear apparatus of a cell [2,3]. Subsequent research demonstrated that cytogenetic aberrations might be caused by both intracellular par asites, including viruses, and extracellular infectious agents, including bacteria, protozoa, and helminthes [4][5][6][7][8]. It is suggested that the induction of chromo somal aberrations is mediated by the occurrence of inflammatory and immunopathological processes in a patient's body.…”

Section: Introductionmentioning

confidence: 99%

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Cytogenetic aberrations in peripheral blood mononuclear cells in acute Lyme borreliosis patients

2013

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Cytogenetic aberrations are known to be caused by biological mutagenic factors, including both intracellular parasites, such as viruses, and some extracellular infectious agents, including bacteria, protozoa, and helminthes. The present study is aimed at investigating the cytogenetic status of acute Lyme borreliosis (LB) patients. As a result of the present study, a peripheral blood mononuclear cell culture of acute LB patients demonstrated a significantly higher frequency of lymphocytes with cytogenetic aberrations of the aneugenic type, such as polyploidy, hypoploidy, or endoreduplication, as well as of the clastogenic type, such as chromatid and chromosomal breaks accompanied by the inhibition of proliferative responses to mitogens and an increase in the elimination of genetically abnormal cells by apoptosis compared to the control.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytogenetic aberrations in peripheral blood mononuclear cells in acute Lyme borreliosis patients

2013

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“…It is possible to make some conclusions about possible mecha- [3,12,13]. It seems to be the most probable explanation that exogenous DNAs which keep matrix properties have regulatory and information impact on cell DNA via the systems for maintenance of genetic stability and involve the same mechanisms as at spontaneous mutagenesis but with participation of alien genetic materials [69,70].…”

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confidence: 99%

“…2). The early E1 area revealed the maximal mutagenic [7,42,43,69,70] and transforming activity [71,76]. The function of proteins of E1A operon consists, mainly, in immortalization of primary mammalian cells, and the proteins encoded by E1B operon are necessary for both induction, and maintenance of transformed state [76].…”

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Regulation of mutagenesis by exogenous biological factors in the eukaryotic cell systems

Лукаш

2013

Biopolym. Cell

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The representations of the mutations and the nature of spontaneous mutation process and mutagenesis induced by exogenous oncoviruses, DNAs and proteins-mitogens are analysed. Exogenous biological factors induce DNA damages in regulatory-informational way, acting on the cellular systems for maintenance of genetical stability. Molecular mechanisms are the same as at spontaneous mutagenesis but they are realized with the participation of alien genetical material. Among biological mutagens, the oncoviruses and mobile genetic elements (MGEs) are distinguished as the strongest destabilizing factors which direct tumor transformation of somatic mammalian cells. Genetical reprogramming or changing the programs of gene expression at the differentiation of stem and progenitor cells under growth factors and citokines is probably followed by mutations and recombinations as well

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Productivity of soybean-rhizobium symbiosis after modification of root nodule bacteria activity with exogenous proteins

Сытников

Kirizii

Malichenko

et al. 2007

Russ J Plant Physiol

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The regulation of a variability of somatic mammalian cell genome under the influence of exogeneous biological factors

Cited by 9 publications

References 42 publications

Cytogenetic aberrations in peripheral blood mononuclear cells in acute Lyme borreliosis patients

Cytogenetic aberrations in peripheral blood mononuclear cells in acute Lyme borreliosis patients

Regulation of mutagenesis by exogenous biological factors in the eukaryotic cell systems

Productivity of soybean-rhizobium symbiosis after modification of root nodule bacteria activity with exogenous proteins

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