The regulation of Hox gene expression during animal development

Mallo, Moisés; Alonso, Claudio R.

doi:10.1242/dev.068346

Cited by 292 publications

(248 citation statements)

References 155 publications

(255 reference statements)

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“…The widespread changes in protein-coding gene expression occurring during mammalian development have been previously explored using gene-specific (Wutz et al 1997;Kyrmizi et al 2006;Mallo and Alonso 2013) and transcriptome-wide approaches (Bruneau 2008;Kang et al 2011;Nord et al 2013). Here, we confirmed that liver and brain development are accompanied by thousands of protein-coding transcript changes, which accurately reflect the tissue and stage identity of all samples.…”

Section: Discussionsupporting

confidence: 71%

High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA–tRNA interface

Schmitt

Rudolph

Karagianni³

et al. 2014

Genome Res.

110

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The genetic code is an abstraction of how mRNA codons and tRNA anticodons molecularly interact during protein synthesis; the stability and regulation of this interaction remains largely unexplored. Here, we characterized the expression of mRNA and tRNA genes quantitatively at multiple time points in two developing mouse tissues. We discovered that mRNA codon pools are highly stable over development and simply reflect the genomic background; in contrast, precise regulation of tRNA gene families is required to create the corresponding tRNA transcriptomes. The dynamic regulation of tRNA genes during development is controlled in order to generate an anticodon pool that closely corresponds to messenger RNAs. Thus, across development, the pools of mRNA codons and tRNA anticodons are invariant and highly correlated, revealing a stable molecular interaction interlocking transcription and translation.

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Section: Discussionsupporting

confidence: 71%

High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA–tRNA interface

Schmitt

Rudolph

Karagianni³

et al. 2014

Genome Res.

110

View full text Add to dashboard Cite

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“…Meis proteins form stable heteromeric complexes with other transcriptional regulators, enhancing their affinity and specificity of binding to DNA sites in the target gene locus (Penkov et al, 2013;Slattery et al, 2011). For example, together with Pbx1, Meis1 plays a major role as a co-factor for the TFs of the Hox complex, which, in turn, have a pivotal and evolutionarily conserved role in orchestrating embryonic trunk development (Duboule, 2007;Mallo and Alonso, 2013). In accordance with this notion, loss of Meis1 function impairs the formation of Meis1-expressing trunk organs and systems, such as the limbs, heart, blood and vasculature (Azcoitia et al, 2005;Erickson et al, 2010;Hisa et al, 2004;Mercader et al, 1999Mercader et al, , 2009Zhang et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Members of the Meis subfamily are however also expressed in the brain and sensory organs (Schulte and Frank, 2014), which are Hox-free embryonic regions (Duboule, 2007;Mallo and Alonso, 2013). In particular, Meis1 is expressed in the vertebrate forebrain and sensory organ primordia, including the eye, being essential for the specification of part of these structures.…”

Section: Introductionmentioning

confidence: 99%

Meis1 coordinates a network of genes implicated in eye development and microphthalmia

et al. 2015

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Microphthalmos is a rare congenital anomaly characterized by reduced eye size and visual deficits of variable degree. Sporadic and hereditary microphthalmos have been associated with heterozygous mutations in genes fundamental for eye development. Yet, many cases are idiopathic or await the identification of molecular causes. Here we show that haploinsufficiency of Meis1, which encodes a transcription factor with evolutionarily conserved expression in the embryonic trunk, brain and sensory organs, including the eye, causes microphthalmic traits and visual impairment in adult mice. By combining analysis of Meis1 loss-offunction and conditional Meis1 functional rescue with ChIP-seq and RNA-seq approaches we show that, in contrast to its preferential association with Hox-Pbx BSs in the trunk, Meis1 binds to Hox/Pbxindependent sites during optic cup development. In the eye primordium, Meis1 coordinates, in a dose-dependent manner, retinal proliferation and differentiation by regulating genes responsible for human microphthalmia and components of the Notch signaling pathway. In addition, Meis1 is required for eye patterning by controlling a set of eye territory-specific transcription factors, so that in Meis1 −/− embryos boundaries among the different eye territories are shifted or blurred. We propose that Meis1 is at the core of a genetic network implicated in eye patterning/microphthalmia, and represents an additional candidate for syndromic cases of these ocular malformations.

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“…These 39 genes are an evolutionary conserved family of genes that play a key role in the development of anteroposterior axis, but also in other physiologic and pathologic processes, such as oncogenesis [38,39]. Several experiments on chicks and mice have shown that Hox-gene mutations can lead to homeotic transformations [40].…”

Section: Discussionmentioning

confidence: 99%

Increased prevalence of abnormal vertebral patterning in fetuses and neonates with trisomy 21

Schut

Broek

Cohen–Overbeek

et al. 2018

The Journal of Maternal-Fetal & Neonatal Medicine

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Purpose: To assess the prevalence of an abnormal number of ribs in a cohort of fetuses and neonates with trisomy 21 and compare this with a subgroup of fetuses without anomalies. Materials and methods: Radiographs of 67 deceased fetuses, neonates, and infants that were diagnosed with trisomy 21 were reviewed. Terminations of pregnancy were included. The control group was composed of 107 deceased fetuses, neonates, and infants without known chromosomal abnormalities, structural malformations, infections or placental pathology. Cases in which the number of thoracic ribs or presence of cervical ribs could not be reliably assessed were excluded. The literature concerning vertebral patterning in trisomy 21 cases and healthy subjects was reviewed. Results: Absent or rudimentary 12th thoracic ribs were found in 26/54 (48.1%) cases with trisomy 21 and cervical ribs were present in 27/47 (57.4%) cases. This prevalence was significantly higher compared to controls (28/100, 28.0%, X 2 (1) ¼ 6.252, p ¼ .012 and 28/97, 28.9%, X 2 (1) ¼ 10.955, p < .001, respectively). Conclusions: Rudimentary or absent 12th thoracic ribs and cervical ribs are significantly more prevalent in deceased fetuses and infants with trisomy 21. ARTICLE HISTORY

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The regulation of Hox gene expression during animal development

Cited by 292 publications

References 155 publications

High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA–tRNA interface

High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA–tRNA interface

Meis1 coordinates a network of genes implicated in eye development and microphthalmia

Increased prevalence of abnormal vertebral patterning in fetuses and neonates with trisomy 21

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