The regulation roles of miRNAs in Helicobacter pylori infection

Tong, Ting; Zhou, You Lang; Huang, Qiaoling; Xiao, Changfa; Bai, Qinqin; Deng, Bo; Chen, Lili

doi:10.1007/s12094-023-03094-9

Cited by 4 publications

(2 citation statements)

References 121 publications

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“…The proliferation and apoptosis of gastric epithelial cells are normal physiological phenomena. H. pylori infection leads to increased apoptosis and proliferation of gastric epithelial cells, but proliferation still dominates, which may be one of the causes of GC 121 . H. pylori induces a strong inflammatory response, which may play an important role in the progression from chronic inflammation to gastric malignancy 122 .…”

Section: Is the Gut Microbiota Implicated In Tumorigenesis?mentioning

confidence: 99%

Role of the gut microbiota in tumorigenesis and treatment

Liu,

Yang,

Pan

et al. 2024

Theranostics

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The gut microbiota is a crucial component of the intricate microecosystem within the human body that engages in interactions with the host and influences various physiological processes and pathological conditions. In recent years, the association between dysbiosis of the gut microbiota and tumorigenesis has garnered increasing attention, as it is recognized as a hallmark of cancer within the scientific community. However, only a few microorganisms have been identified as potential drivers of tumorigenesis, and enhancing the molecular understanding of this process has substantial scientific importance and clinical relevance for cancer treatment. In this review, we delineate the impact of the gut microbiota on tumorigenesis and treatment in multiple types of cancer while also analyzing the associated molecular mechanisms. Moreover, we discuss the utility of gut microbiota data in cancer diagnosis and patient stratification. We further outline current research on harnessing microorganisms for cancer treatment while also analyzing the prospects and challenges associated with this approach.

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Section: Is the Gut Microbiota Implicated In Tumorigenesis?mentioning

confidence: 99%

Role of the gut microbiota in tumorigenesis and treatment

Liu,

Yang,

Pan

et al. 2024

Theranostics

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“…The third popular topic is the mutual effects between miRNAs and Helicobacter pylori (H. pylori) on GC. On the one hand, H. pylori can affect the expression levels of miRNAs by promoting DNA methylation (70,71) and inducing or inhibiting the activation of transcription factors (58,72), thereby promoting cell proliferation, inhibiting cell apoptosis, participating in the regulation of inflammatory processes, and regulating cell autophagy, invasion, and migration (73)(74)(75). On the other hand, miRNAs can in turn affect the colonization of H. pylori by altering host related metabolism and regulating the progression of GC induced by H. pylori (14,76).…”

Section: Research Hotspotsmentioning

confidence: 99%

Bibliometric and visualized analysis of global research on microRNAs in gastric cancer: from 2013 to 2023

Wang,

Han

et al. 2024

Front. Oncol.

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Gastric cancer (GC) imposes a heavy burden on global public health, and microRNAs (miRNAs) play a crucial role in the diagnosis and treatment of GC. Therefore, it is necessary to clarify the hotspots and frontiers in the field of miRNAs in GC to guide future research. A total of 2,051 publications related to miRNAs in GC from January 2013 to December 2023 were searched from the Web of Science Core Collection database. CiteSpace was used to identify research hotspots and delineate developmental trends. In the past decade, China, Nanjing Medical University, and Ba Yi were the most contributing research country, institute, and author in this field, respectively. The role of miRNAs as biomarkers in GC, the mechanism of miRNAs in the progression of GC, and the impact of the mutual effects between miRNAs and Helicobacter pylori on GC have been regarded as the research hotspots. The mechanisms of miRNAs on glucose metabolism and the application of the roles of circular RNAs as miRNA sponges in GC treatment will likely be frontiers. Overall, this study called for strengthened cooperation to identify targets and therapeutic regimes for local specificity and high-risk GC types, and to promote the translation of research results into clinical practice.

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MiR-124-3p/EIF3B Regulates Host Cell Apoptosis Induced by Chlamydia psittaci Through PI3K/AKT Signaling Pathway

Tong,

Li,

Zhou

et al. 2024

The Journal of Infectious Diseases

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Chlamydia psittaci is a zoonotic pathogen known to cause respiratory diseases in humans. Chlamydia infections are closely associated with apoptosis, in which miRNAs play regulatory roles. Herein, we demonstrated that C. psittaci infection induces apoptosis in human bronchial epithelial (HBE) cells and investigated regulatory mechanism involving miR-124-3p and the PI3K/AKT signaling pathway. Following C. psittaci infection in HBE cells, we observed an elevated of HBE cells apoptosis, accompanied by upregulation of miR-124-3p levels. Mechanistically, we identified EIF3B as a novel target gene of miR-124-3p, supported by the inverse correlation of their mRNA expressions. MiR-124-3p inhibitors reduced apoptosis induced by C. psittaci, increased the replication of C. psittaci and inhibited the PI3K/AKT activated, whereas miR-124-3p mimics produced opposite effects, and transfection with EIF3B siRNA reversed the effects of miR-124-3p inhibitors. Our findings suggest that miR-124-3p targeting EIF3B promotes apoptosis in C. psittaci-infected HBE cells through the activation of PI3K/AKT signaling pathway.

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The regulation roles of miRNAs in Helicobacter pylori infection

Cited by 4 publications

References 121 publications

Role of the gut microbiota in tumorigenesis and treatment

Role of the gut microbiota in tumorigenesis and treatment

Bibliometric and visualized analysis of global research on microRNAs in gastric cancer: from 2013 to 2023

MiR-124-3p/EIF3B Regulates Host Cell Apoptosis Induced by Chlamydia psittaci Through PI3K/AKT Signaling Pathway

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