The regulatory effects of<i>Cissus quadrangularis</i>on some enzymes involved in carbohydrate metabolism in streptozotocin-induced diabetic rats

Lekshmi, R.; Sreekutty, M S; Mini, S.

doi:10.3109/13880209.2014.970286

Cited by 8 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The actions of these two enzymes may be attributed to the increased glucose production during the diabetic condition by the liver [30]. significantly in diabetic rats [31]. The oral treatment of I. pes-caprae ethanolic leaf extract significantly declined the activities of glucose-6-phosphatase and fructose-1, 6bisphosphatase in STZ-induced diabetic rats, which may lead to the suppression of glucose production from noncarbohydrate substances.…”

Section: Discussionmentioning

confidence: 99%

“…The liver is the vital organ that is involved in the blood glucose homeostasis in the body. Both the liver and kidney exhibit various morphological as well as functional modifications during diabetes [31]. The diabetic control liver showed damaged hepatocytes with periportal necrosis near the portal region with dilated as well as congestion in the portal vessels and inflammatory cell infiltration.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ameliorative effect of Ipomoea pes-caprae ethanolic leaf extract on carbohydrate metabolizing enzymes and oxidative status in Streptozotocin-induced diabetic Wistar rats

Suhasini¹,

Elanchezhiyan²,

Chandirasegaran³

2019

J. Drug Delivery Ther.

View full text Add to dashboard Cite

In diabetic patients, hyperglycemia is developed due to increased hepatic glucose production and impaired utilization of glucose in cells, which leads to oxidative stress in cells. Ipomoea pes-caprae has been widely used as an oral treatment for many diseases. The aim of the present study is to assess the effect of Ipomoea pes-caprae ethanolic leaf extract on carbohydrate metabolizing enzymes and oxidative status in Streptozotocin (STZ) induced experimental diabetic rats. Experimental diabetic rats were induced by intraperitoneal administration of 55 mg/kg b.w of STZ. Diabetic rats were treated with I. pes-caprae ethanolic leaf extract at a concentration of 300 mg/kg b.w and glibenclamide (6 mg/kg b.w) for 45 days. Diabetic rats exhibited significant (P < 0.05) decline in the activity of glucokinase and glucose-6-phosphate dehydrogenase, enzymatic antioxidants (SOD, CAT and GPx) and non-enzymatic antioxidants (GSH, vitamin E and vitamin C), while lipid peroxidation markers (LOOH and TBARS) and glucose-6-phosphatase and fructose-1, 6-bisphosphatase were found to be significantly increased. Further in diabetic rats, the histopathology of pancreas, liver and kidney showed abnormal histo-architecture. The treatment with Ipomoea pes-caprae ethanolic leaf extract notably reversed the abnormal levels in carbohydrate metabolizing enzymes, restored the oxidative status and abnormal structures in pancreas, liver and kidney to near normal levels. Keywords: Diabetes, antioxidant, lipid peroxidation, Ipomoea pes-caprae and carbohydrate metabolizing enzymes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of Ipomoea pes-caprae ethanolic leaf extract on carbohydrate metabolizing enzymes and oxidative status in Streptozotocin-induced diabetic Wistar rats

Suhasini¹,

Elanchezhiyan²,

Chandirasegaran³

2019

J. Drug Delivery Ther.

View full text Add to dashboard Cite

show abstract

“…C. quadrangularis Linn. is a magnificent plant having enormous beneficial role in being effective against Diabetes mellitus (Lekshmi et al 2015). It has also found to be having antimicrobial and antioxidant property (Deshpande et al 2023).…”

Section: Introductionmentioning

confidence: 99%

Distribution of endophytic fungi in the leaf and stem of Cissus quadrangularis Linn. - A comparative study

Deka,

Patgiri,

Sharma

2023

TJB

View full text Add to dashboard Cite

The present study focused on the diversity and distribution of endophytic fungal species in different plant parts (stems and leaves) of the plant Cissus quadrangularis Linn. collected from different locations of Assam, India. Plant samples were collected from three districts, Kamrup, Barpeta and Biswanath of Assam for endophytic fungal isolation. Variation was found in the distribution of fungal endophytes in stems and leaves of the plant collected from different locations under study. The percentage isolation of the endophytic fungal isolates was more from the stems collected from Kamrup (M) whereas the percentage isolation of endophytic fungal isolates was more from the leaves collected from Biswanath Chariali and Barpeta. Shannon-diversity and Simpson diversity indices of fungal endophytes varied in stems and leaves of the plant under study. This variation can be attributed to the soil conditions of the sampling site as well as the seasonal variation during sampling periods. Cladosporium sp. and Fusarium sp., are the most dominant and frequently occurring endophytic fungal species in C. quadrangularis of Kamrup (M) and Barpeta districts. Colletotrichum sp. and Rhizopus sp. were the dominant endophytic fungal species in Biswanath district. Since C. quadrangularis is used traditionally in the treatments of bone fracture, the study of endophytes associated to this plant could be of paramount significance with a scope of identifying the potent endophytes that are capable of producing bioactive compounds necessary in bone-healing.

show abstract

Larvicidal and repellent activity of N-methyl-1-adamantylamine and oleic acid a major derivative of bael tree ethanol leaf extracts against dengue mosquito vector and their biosafety on natural predator

Chellappandian

Senthil-Nathan

Karthi

et al. 2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

The regulatory effects ofCissus quadrangularison some enzymes involved in carbohydrate metabolism in streptozotocin-induced diabetic rats

Abstract: The current study suggests the antidiabetic potential of CQSF, mediated through the regulation of carbohydrate metabolic enzyme activities.

Cited by 8 publications

References 27 publications

Ameliorative effect of Ipomoea pes-caprae ethanolic leaf extract on carbohydrate metabolizing enzymes and oxidative status in Streptozotocin-induced diabetic Wistar rats

Ameliorative effect of Ipomoea pes-caprae ethanolic leaf extract on carbohydrate metabolizing enzymes and oxidative status in Streptozotocin-induced diabetic Wistar rats

Distribution of endophytic fungi in the leaf and stem of Cissus quadrangularis Linn. - A comparative study

Larvicidal and repellent activity of N-methyl-1-adamantylamine and oleic acid a major derivative of bael tree ethanol leaf extracts against dengue mosquito vector and their biosafety on natural predator

Contact Info

Product

Resources

About