The regulatory role of melatonin in skeletal muscle

Chen, Bide; Shan, Tizhong

doi:10.1007/s10974-020-09578-3

Cited by 17 publications

(11 citation statements)

References 77 publications

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“…In Japanese elderly population, the urine concentration of 6-sulfatoxymelatonin was significantly associated with grip strength and quadriceps strength [73]. There are many studies concerning the effects of melatonin in muscle including protective effect of muscle stem cells and suppressive effect on inflammatory response [74]. The promotive effect on mitochondrial respiratory chain supercomplex formation could be added to those mechanisms.…”

Section: Roles Of Supercomplex Assembly Factors and Molecules Affecti...mentioning

confidence: 99%

Functional Mechanisms of Mitochondrial Respiratory Chain Supercomplex Assembly Factors and Their Involvement in Muscle Quality

Azuma

Ikeda

Inoue

2020

IJMS

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Impairment of skeletal muscle function causes disabilities in elderly people. Therefore, in an aged society, prevention and treatment of sarcopenia are important for expanding healthy life expectancy. In addition to aging, adipose tissue disfunction and inflammation also contribute to the pathogenesis of sarcopenia by causing the combined state called ‘sarcopenic obesity’. Muscle quality as well as muscle mass contributes to muscle strength and physical performance. Mitochondria in the skeletal muscles affect muscle quality by regulating the production of energy and reactive oxygen species. A certain portion of the mitochondrial respiratory chain complexes form a higher-order structure called a “supercomplex”, which plays important roles in efficient energy production, stabilization of respiratory chain complex I, and prevention of reactive oxygen species (ROS) generation. Several molecules including phospholipids, proteins, and certain chemicals are known to promote or stabilize mitochondrial respiratory chain supercomplex assembly directly or indirectly. In this article, we review the distinct mechanisms underlying the promotion or stabilization of mitochondrial respiratory chain supercomplex assembly by supercomplex assembly factors. Further, we introduce regulatory pathways of mitochondrial respiratory chain supercomplex assembly and discuss the roles of supercomplex assembly factors and regulatory pathways in skeletal muscles and adipose tissues, believing that this will lead to discovery of potential targets for prevention and treatment of muscle disorders such as sarcopenia.

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Section: Roles Of Supercomplex Assembly Factors and Molecules Affecti...mentioning

confidence: 99%

Functional Mechanisms of Mitochondrial Respiratory Chain Supercomplex Assembly Factors and Their Involvement in Muscle Quality

Azuma

Ikeda

Inoue

2020

IJMS

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“…Impact of sleep on stem cell regenerative capacity is shown by the correlation between circadian rhythm and an improved stem cells proliferation microenvironment [108] leading to stem cell maintenance and division control [109,110]. This fits with the melatonin anti-inflammatory, antioxidant and neuroprotective properties [111,112] along with its free radical scavenger function [113], among others, that would be behind its role in regeneration of tissues [111,113]. In addition, protein and pre-sleep are also contributors to regeneration [114,115].…”

Section: Exercise Diet Sleeping and Regenerationmentioning

confidence: 87%

Exercise, Diet and Sleeping as Regenerative Medicine Adjuvants: Obesity and Ageing as Illustrations

2022

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Regenerative medicine uses the biological and medical knowledge on how the cells and tissue regenerate and evolve in order to develop novel therapies. Health conditions such as ageing, obesity and cancer lead to an impaired regeneration ability. Exercise, diet choices and sleeping pattern have significant impacts on regeneration biology via diverse pathways including reducing the inflammatory and oxidative components. Thus, exercise, diet and sleeping management can be optimized towards therapeutic applications in regenerative medicine. It could allow to prevent degeneration, optimize the biological regeneration and also provide adjuvants for regenerative medicine.

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“…Melatonin is suggested to alleviate myofiber size, mitochondria fusion, cristae preservation, and satellite cells in skeletal muscle disorders by inhibition of megamitochondria, reactive oxygen species (ROS) production, inflammation as well as apoptosis [ 106 ]. Although melatonin can protect skeletal muscle, the specific mechanism especially the process of muscle differentiation and fusion is still unclear [ 107 ].…”

Section: Effect Of Melatonin On Obesitymentioning

confidence: 99%

Mechanisms of Melatonin in Obesity: A Review

Guan

Wang

Cao

et al. 2021

IJMS

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Obesity and its complications have become a prominent global public health problem that severely threatens human health. Melatonin, originally known as an effective antioxidant, is an endogenous hormone found throughout the body that serves various physiological functions. In recent decades, increasing attention has been paid to its unique function in regulating energy metabolism, especially in glucose and lipid metabolism. Accumulating evidence has established the relationship between melatonin and obesity; nevertheless, not all preclinical and clinical evidence indicates the anti-obesity effect of melatonin, which makes it remain to conclude the clinical effect of melatonin in the fight against obesity. In this review, we have summarized the current knowledge of melatonin in regulating obesity-related symptoms, with emphasis on its underlying mechanisms. The role of melatonin in regulating the lipid profile, adipose tissue, oxidative stress, and inflammation, as well as the interactions of melatonin with the circadian rhythm, gut microbiota, sleep disorder, as well as the α7nAChR, the opioidergic system, and exosomes, make melatonin a promising agent to open new avenues in the intervention of obesity.

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The regulatory role of melatonin in skeletal muscle

Cited by 17 publications

References 77 publications

Functional Mechanisms of Mitochondrial Respiratory Chain Supercomplex Assembly Factors and Their Involvement in Muscle Quality

Functional Mechanisms of Mitochondrial Respiratory Chain Supercomplex Assembly Factors and Their Involvement in Muscle Quality

Exercise, Diet and Sleeping as Regenerative Medicine Adjuvants: Obesity and Ageing as Illustrations

Mechanisms of Melatonin in Obesity: A Review

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