The regulatory role of microRNAs in the development, cyclic changes, and cell differentiation of the hair follicle

Mokabber, Haleh; Vatankhah, Mohammad Amin; Najafzadeh, Nowruz

doi:10.1016/j.procbio.2022.01.016

Cited by 4 publications

(1 citation statement)

References 75 publications

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“…Small noncoding RNAs (miRNAs) have been linked to apopto sis, carcinogenesis, and chemoresistance in cancer cells [6][7][8]. Cur cumin has been shown to influence the expression of microRNAs (miRNAs) in cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Upregulates miR-148a to Increase the Chemosensitivity of CD44-Positive Prostate Cancer Stem Cells to Paclitaxel Through Targeting the MSK1/IRS1 axis

et al. 2022

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Background In men, prostate cancer (PC) is the second most common cause of cancer-related death. However, paclitaxel resistance is a major challenge in advanced PC. Curcumin, a natural antioxidant, has been demonstrated to have cytotoxic effects on cancer stem cells (CSCs). The goal of this study is to explore if curcumin can help lower chemoresistance to paclitaxel through the regulation of miR-148a-mediated apoptosis in prostate CSCs. Methods The 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and 4′,6-diamidino-2-phenylindole (DAPi) labeling were used to determine cell survival. Immunohistochemistry was used to detect the expression of P-glycoprotein protein (P-gp) and CD44 proteins. Finally, real-time PCR was used to evaluate the regulatory effects of curcumin and paclitaxel on miR-148a and its target genes. Results Curcumin and paclitaxel co-treatment significantly reduced the IC50 value in CD44+cells compared to paclitaxel alone. Additionally, combining these drugs considerably increased apoptosis in CD44+cells. We also discovered that when curcumin and paclitaxel were combined, the expression of CD44 and P-gp was significantly reduced compared to paclitaxel alone. Curcumin and paclitaxel co-treatment also increased miR-148a levels and regulated the levels of its target genes MSK1 and IRS1. Conclusion Curcumin may restore paclitaxel sensitivity by raising miR-148a expression and inhibiting its target genes.

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Section: Introductionmentioning

confidence: 99%

Curcumin Upregulates miR-148a to Increase the Chemosensitivity of CD44-Positive Prostate Cancer Stem Cells to Paclitaxel Through Targeting the MSK1/IRS1 axis

et al. 2022

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MicroRNA expression profiles reveal wool development and fineness regulation in Gansu alpine fine-wool sheep

He,

Sun,

Zhao

et al. 2024

Genomics

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Multistage Transdermal Nitric Oxide Delivery System for the Efficient Treatment of Androgenic Alopecia

Xing,

Jiang,

Zhao

et al. 2024

ACS Materials Lett.

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Androgenic alopecia (AGA) is a prevalent progressive hair loss condition. The main therapeutic drug, minoxidil, is limited by its poor efficacy and side effects such as contact dermatitis and hypertrichosis. Nitric oxide (NO), an endothelial-derived relaxing factor, promotes angiogenesis and accelerates blood flow, enhancing nutrient supply similar to minoxidil. Accordingly, we utilized a poly(vinyl alcohol) film (PVA) loaded with hyaluronic acid (HA) liposomes to construct a multistage transdermal NO delivery system (PVA@HL/NONOate) for the treatment of AGA. The HA liposomes provided efficient NO loading and extended release, while the PVA film improved skin penetration and sustained NO release, increasing NO bioavailability. Low-concentration NO effectively enhanced hair follicle vitality and repaired blood vessels. Mechanistically, low-concentration NO could treat AGA mainly by regulating the HIF-1 signaling pathway to promote angiogenesis, reducing inflammation by downregulating the expression of TNFRSF9 and IL-6, repairing hair follicles by downregulating the expression of genes in the CXCL5-IL-17 inflammatory axis.

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The regulatory role of microRNAs in the development, cyclic changes, and cell differentiation of the hair follicle

Cited by 4 publications

References 75 publications

Curcumin Upregulates miR-148a to Increase the Chemosensitivity of CD44-Positive Prostate Cancer Stem Cells to Paclitaxel Through Targeting the MSK1/IRS1 axis

Curcumin Upregulates miR-148a to Increase the Chemosensitivity of CD44-Positive Prostate Cancer Stem Cells to Paclitaxel Through Targeting the MSK1/IRS1 axis

MicroRNA expression profiles reveal wool development and fineness regulation in Gansu alpine fine-wool sheep

Multistage Transdermal Nitric Oxide Delivery System for the Efficient Treatment of Androgenic Alopecia

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