The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future

Ortega, Miguel Á.; Fraile-Martínez, Óscar; Guijarro, Luis; Casanova, Carlos; Coca, Santiago; Álvarez‐Mon, Melchor; Buján, Julia; García‐Honduvilla, Natalio; Asúnsolo, Ángel

doi:10.3390/cancers12092443

Cited by 31 publications

(21 citation statements)

References 183 publications

(177 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have found that specific miRNAs are associated with breast cancer [ 36 , 37 ]. Studies on the clinical applications of miRNAs, such as in diagnosis, prognosis, and therapeutic strategies for cancer, including breast cancer, are also gaining prominence [ 21 ]. Here, a systematic analysis of miRNA expression profiles from TCGA was performed to identify potential miRNAs for the diagnosis of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…They lead to the silencing of respective gene expression either by direct degradation of mRNA or inhibition of protein translation [ 11 , 12 ]; miRNAs are involved in a wide range of cancer biology processes, including regulation of target mRNA expression, which promotes tumor growth, apoptosis, progression, metastasis, and immune evasion [ 13 , 14 , 15 , 16 ]. Many studies have reported that miRNAs play key roles in the occurrence and progression of breast cancer [ 17 , 18 , 19 , 20 ]; this has prompted translational studies on miRNAs for breast cancer to be actively conducted [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of MicroRNAs as Diagnostic Biomarkers for Breast Cancer Based on the Cancer Genome Atlas

Kim

2021

Diagnostics

View full text Add to dashboard Cite

Breast cancer is the most common cancer among women worldwide. MicroRNAs (miRNAs or miRs) play an important role in tumorigenesis, and thus, they have been identified as potential targets for translational research with diagnostic, prognostic, and therapeutic markers. This study aimed to identify differentially expressed (DE) miRNAs in breast cancer using the Cancer Genome Atlas. The miRNA profiles of 755 breast cancer tissues and 86 adjacent non-cancerous breast tissues were analyzed using Multi Experiment Viewer; miRNA–mRNA network analyses and constructed KEGG pathways with the predicted target genes were performed. The clinical relevance of miRNAs was investigated using area under the receiver operating characteristic curve (AUC) analysis, sensitivity, and specificity. The analysis identified 28 DE miRNAs in breast cancer tissues, including nine upregulated and 19 downregulated miRNAs, compared to non-cancerous breast tissues (p < 0.001). The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. Moreover, 1381 potential target genes were predicted using the prediction database tool, miRNet. These genes are related to PD-L1 expression and PD-1 checkpoint in cancer, MAPK signaling, apoptosis, and TNF pathways; hence, they regulate the development, progression, and immune escape of cancer. Thus, these 28 miRNAs can serve as prospective biomarkers for the diagnosis of breast cancer. Taken together, these results provide insight into the pathogenic mechanisms and potential therapies for breast cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of MicroRNAs as Diagnostic Biomarkers for Breast Cancer Based on the Cancer Genome Atlas

Kim

2021

Diagnostics

View full text Add to dashboard Cite

show abstract

“…As mentioned before, mitomiRs have been described as novel players in both physiologic and pathologic conditions [ 100 , 101 ]. miR-1 is responsible for protecting heart structure and functions against hypertrophy, maintaining cardiovascular health.…”

Section: Mitochondrial Mirnas—potential Contribution For Regeneratmentioning

confidence: 99%

“…Similarly, the therapeutic potential of miRNAs, namely mitochondrial ones, is promising as they have proven to be novel players in several diseases such as cancer, metabolic and neurodegenerative diseases [ 100 , 101 ]. However, firstly, the extent of mitomiRs’ regulatory effects must be assessed as well as delivery processes that allow mitomiRs to target mitochondria, minimizing off-target effects [ 141 ].…”

Section: Emerging Therapies In Regenerative Medicinementioning

confidence: 99%

Mitochondrial microRNAs: A Putative Role in Tissue Regeneration

Rodrigues

Cardoso

Duarte

2020

Biology

View full text Add to dashboard Cite

The most famous role of mitochondria is to generate ATP through oxidative phosphorylation, a metabolic pathway that involves a chain of four protein complexes (the electron transport chain, ETC) that generates a proton-motive force that in turn drives the ATP synthesis by the Complex V (ATP synthase). An impressive number of more than 1000 mitochondrial proteins have been discovered. Since mitochondrial proteins have a dual genetic origin, it is predicted that ~99% of these proteins are nuclear-encoded and are synthesized in the cytoplasmatic compartment, being further imported through mitochondrial membrane transporters. The lasting 1% of mitochondrial proteins are encoded by the mitochondrial genome and synthesized by the mitochondrial ribosome (mitoribosome). As a result, an appropriate regulation of mitochondrial protein synthesis is absolutely required to achieve and maintain normal mitochondrial function. Regarding miRNAs in mitochondria, it is well-recognized nowadays that several cellular mechanisms involving mitochondria are regulated by many genetic players that originate from either nuclear- or mitochondrial-encoded small noncoding RNAs (sncRNAs). Growing evidence collected from whole genome and transcriptome sequencing highlight the role of distinct members of this class, from short interfering RNAs (siRNAs) to miRNAs and long noncoding RNAs (lncRNAs). Some of the mechanisms that have been shown to be modulated are the expression of mitochondrial proteins itself, as well as the more complex coordination of mitochondrial structure and dynamics with its function. We devote particular attention to the role of mitochondrial miRNAs and to their role in the modulation of several molecular processes that could ultimately contribute to tissue regeneration accomplishment.

show abstract

“…Moreover, choice of systemic therapies such as adjuvant and neoadjuvant therapies frequently represent important procedures, depending on the lymph involvement, menopausal status, or BC subtype [ 15 ]. Among them, endocrine therapy like aromatase inhibitors (AI) or Herceptin (Trastuzumab) are prominent approaches for luminal and HER2-enriched subtypes respectively [ 16 ], whereas for aggressive TNBC tumors, immunotherapy together with novel molecular targets are being used, including microRNAs, PARP (Poly ADP-ribose polymerase), or PI3K (Phosphoinositide 3-kinases) inhibitors [ 17 , 18 , 19 ]. Thus, advances in the therapies provided for the patients, along with early diagnosis and screening, have provoked a noteworthy reduction in overall cancer mortality and cancer-specific survival during the last decades in Europe [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Physical Activity as an Imperative Support in Breast Cancer Management

Ortega

Fraile-Martínez

García-Montero

et al. 2020

Cancers

Self Cite

View full text Add to dashboard Cite

Breast cancer (BC) is the most common malignancy and the second cause of cancer-related death among women. It is estimated that 9 in 10 cases of BC are due to non-genetic factors, and approximately 25% to 30% of total breast cancer cases should be preventable only by lifestyle interventions. In this context, physical activity represents an excellent and accessible approach not only for the prevention, but also for being a potential support in the management of breast cancer. The present review will collect the current knowledge of physical activity in the background of breast cancer, exploring its systemic and molecular effects, considering important variables in the training of these women and the evidence regarding the benefits of exercise on breast cancer survival and prognosis. We will also summarize the various effects of physical activity as a co-adjuvant therapy in women receiving different treatments to deal with its adverse effects. Finally, we will reveal the impact of physical activity in the enhancement of quality of life of these patients, to conclude the central role that exercise must occupy in breast cancer management, in an adequate context of a healthy lifestyle.

show abstract

The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future

Cited by 31 publications

References 183 publications

Identification of MicroRNAs as Diagnostic Biomarkers for Breast Cancer Based on the Cancer Genome Atlas

Identification of MicroRNAs as Diagnostic Biomarkers for Breast Cancer Based on the Cancer Genome Atlas

Mitochondrial microRNAs: A Putative Role in Tissue Regeneration

Physical Activity as an Imperative Support in Breast Cancer Management

Contact Info

Product

Resources

About