The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training-II. The RehAtt Study: rationale, design and methodology

Salvadori, Emilia; Poggesi, Anna; Valenti, Raffaella; Rocca, Eleonora Della; Diciotti, Stefano; Mascalchi, Mario; Inzitari, Domenico; Pantoni, Leonardo

doi:10.1007/s10072-016-2649-z

Cited by 12 publications

(10 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The RehAtt (Rehabilitation of Attention) study is a 3-year prospective, single-blinded, randomized clinical trial. Its rationale and methodology were extensively reported elsewhere [ 6 ]. Methodological details concerning sample size justification, method of randomization, and interventions are detailed in the Supplementary Material .…”

Section: Methodsmentioning

confidence: 99%

“…At baseline, according to the study protocol [ 6 ], each patient underwent an extensive clinical, functional, and neuropsychological assessment and an MRI examination. The neuropsychological evaluation was carried out using the VMCI-Tuscany neuropsychological battery [ 10 ].…”

Section: Methodsmentioning

confidence: 99%

“…After baseline assessment, participants were randomly assigned to the intervention group (attention training) or the control group (standard care), according to a stratified randomization (see Supplementary Material ) [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Attention Training in Mild Cognitive Impairment Patients with Subcortical Vascular Changes: The RehAtt Study

Pantoni

Poggesi

Diciotti

et al. 2017

JAD

Self Cite

View full text Add to dashboard Cite

Abstract.Background and Objective: Mild cognitive impairment (MCI) patients with small vessel disease (SVD) are at high dementia risk. We tested the effects of cognitive rehabilitation in these patients using the Attention Process Training-II (APT-II) program in a single-blinded, randomized clinical trial. Methods: Patients were randomized to APT-II or standard care and evaluated at baseline, 6, and 12 months with functional, quality of life, cognitive tests, and resting state functional MRI (rsfMRI). Results: Forty-six patients were enrolled and 43 (mean ± SD age 75.1 ± 6.8) completed the study. No change was seen in functionality and quality of life between treated and non-treated patients. However, the Rey Auditory-Verbal Learning Test immediate recall showed a significant improvement in treated compared to non-treated group (change score 6 versus 12 months: 1.8 ± 4.9 and -1.4 ± 3.8, p = 0.021; baseline versus 12 months: 3.8 ± 6.1 and 0.2 ± 4.4, p = 0.032). A higher proportion of treated patients had stable/better evaluation compared to non-treated group on Visual search test (6 versus 12 months: 95% versus 71%, p = 0.038) and Rey-Osterrieth Complex Figure copy (6 versus 12 months: 95% versus 67%, p = 0.027). RsfMRI, performed in a subsample, showed that the difference between follow-up and baseline in synchronization of activity in cerebellar areas was significantly greater in treated than in non-treated patients. Conclusion:We were unable to show a significant effect in quality of life or functional status in treated patients with MCI and SVD. However, APT-II produces some beneficial effects in focused attention and working memory and seems to increase activity in brain circuits involved in cognitive processes.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Attention Training in Mild Cognitive Impairment Patients with Subcortical Vascular Changes: The RehAtt Study

Pantoni

Poggesi

Diciotti

et al. 2017

JAD

Self Cite

View full text Add to dashboard Cite

show abstract

“…Participants of included studies should be diagnosed with CSVD-VCI. Up till now, there is still no globally recognized diagnostic criteria for CSVD-VCI, and therefore, our review will include patients diagnosed with CSVD-VCI according to diagnostic criteria in the international randomized controlled trials[ 59 60 61 62 ] or Clinical Practice Guideline for Cognitive Impairment of Cerebral Small Vessel Disease proclaimed by Geriatric Neurology Group, Chinese Society of Geriatrics in 2019. [63] Briefly speaking, these diagnostic criteria contain 3 key points: subjective cognitive decline and objective evidence of cognitive impairment, neuroimaging evidence of CSVD, and identification of CSVD as evidence of cognitive impairment (namely, exclusion of cognitive impairment caused by other diseases).…”

Section: Methodsmentioning

confidence: 99%

Chinese herbal medicine for vascular cognitive impairment in cerebral small vessel disease

Zhang¹,

Liu²,

Xia

et al. 2020

Medicine

View full text Add to dashboard Cite

Background: Cerebral small vessel disease (CSVD) is the most common etiology of vascular cognitive impairment (VCI). VCI in CSVD (CSVD-VCI) shows a progressive course with multiple stages and is also associated with dysfunctions such as gait, emotional and behavioral, and urinary disturbances, which seriously affect the life quality of elderly people. In mainland China, Chinese herbal medicine (CHM) is clinically used for CSVD-VCI and presenting positive efficacy, but the evidence revealed in relevant clinical trials has not been systematically evaluated. The purpose of this study is to assess the current evidence available for the clinical efficacy and safety of CHM for CSVD-VCI. Methods: A literature search of published RCTs up to April 30, 2020, has been conducted in the following 7 electronic databases: PubMed, Embase, the Cochrane Library, Chinese National Knowledge Infrastructure Database (CNKI), Chinese Science and Technology Journals Database (VIP), Wanfang Database, and Chinese Biomedical Literature Service System (SinoMed). For unpublished studies, 2 clinical trial online registration websites will be searched: ClinicalTrials.gov and Chinese Clinical Trial Registry (ChiCTR). Only randomized controlled trials (RCTs) using CHM in the treatment of patients with CSVD-VCI, which compares CHM with no treatment, placebo, or other conventional treatments, will be included in this systematic review. Primary outcomes will be set as acknowledged scales measuring cognitive function. Secondary outcomes will involve activities of daily living, behavioral, and psychological symptoms, global performance of dementia, neurological function, biological markers of endothelial dysfunction, the clinical effective rate, and adverse events. After screening studies and extracting data, the Cochrane Collaborations tool for assessing risk of bias will be applied to assess the methodological quality of included RCTs. Review Manager Version 5.3 software will be used for data synthesis and statistical analysis. Subgroup analyses, sensitivity analyses, and meta-regression will be conducted to detect potential sources of heterogeneity. The funnel plot and Eggers test will be developed to evaluate publication bias, if available. We will perform the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to appraise the quality of evidence. Results: Evidence exhibited in this systematic review will provide practical references in the field of CHM treating CSVD-VCI. Moreover, our detailed appraisals of methodological deficiencies of relevant RCTs will offer helpful advice for researchers who are designing trials of CHMs in the treatment of CSVD-VCI. Conclusion: The conclusion about the clinical efficacy and safety of CHM for CSVD-VCI will be provided for clinical plans, decisions, and policy developments in the full version of this systematic review. Systematic review registr...

show abstract

“…These processes include focused attention, sustained attention, attention span, selective attention and vigilance, alternating attention, and divided attention. 20,21 As noted, arousal and vigilance are basic functions while selective, transfer, and divided attention are complex functions. 10 On this basis, the training was carried out gradually (referred to as gradual attention training), depending on the patients’ attention ability.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic effect of gradual attention training on language function in patients with post-stroke aphasia: a pilot study

Zhang

et al. 2019

Clin Rehabil

View full text Add to dashboard Cite

Objective: To investigate the effect of gradual attention training on language function with aphasia. Design: Randomized controlled trial. Participants: A total of 40 patients (mean age: 53.47 years) with post-stroke aphasia came from the stroke rehabilitation unit of rehabilitation department in the First Hospital of Jilin University, of which 13 (32.5%) had intracerebral hemorrhage, 28 inpatients and 12 outpatients, 11 women and 29 men, 34 within three-month stroke and 6 within three months to one year. Interventions: All participants were divided into control and experimental groups. Both groups received language treatment 20 minutes a day, six days/week, for five weeks, and the experimental group received gradual attention training 20 minutes a day, six days/week, for five weeks. Main measures: Language function was assessed pre- and post-treatment by components of the Western Aphasia Battery (WAB) which included spontaneous speech, auditory comprehension, repetition, and naming and then calculated the aphasia quotient (AQ). Results: The mean (SD) AQ of the experimental group and control group, respectively, was 25.71 (12.63) and 26.2 (12.31) at baseline. After treatment, the AQ mean (SD) was 43.08 (15.14) in the experimental group, which showed a significant improvement compared to 33.48 (14.04) in the control group ( P = 0.02).All items of WAB were higher in experimental group than those in control group, especially in auditory comprehension and naming ( P = 0.02, 0.01). Conclusion: Gradual attention training seemed to improve language function in post-stroke aphasia, specifically function of listening comprehension and naming.

show abstract

The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training-II. The RehAtt Study: rationale, design and methodology

Abstract: NCT02033850 (ClinicalTrials.gov Identifier).

Cited by 12 publications

References 39 publications

Effect of Attention Training in Mild Cognitive Impairment Patients with Subcortical Vascular Changes: The RehAtt Study

Effect of Attention Training in Mild Cognitive Impairment Patients with Subcortical Vascular Changes: The RehAtt Study

Chinese herbal medicine for vascular cognitive impairment in cerebral small vessel disease

Therapeutic effect of gradual attention training on language function in patients with post-stroke aphasia: a pilot study

Contact Info

Product

Resources

About