The reinforced hydrogel for drug loading: immobilization of single-walled carbon nanotubes in cross-linked polymers via multiple interactions

Sankar, Rajavelu Murali; Meera, K.; Samanta, Debasis; Murali, Adhigan; Panneerselvam, Jithendra; Mandal, Asit Baran; Jaisankar, Sellamuthu N.

doi:10.1039/c2ra22483f

Cited by 19 publications

(12 citation statements)

References 74 publications

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“…From the calculation, we observed that the intensity ratio (I D /I G ) and diameter of SWCNTs in composite is differed from the native SWCNTs (Table 2) due to the interactions between PUA and SWCNT surface (Fig. 3) [14]. This finding supports and further evidences the interaction PUA and SWCNTs.…”

Section: Resultssupporting

confidence: 73%

Studies on Inter and Intra Molecular Hydrogen Bonding and Morphologies of Single-walled Carbon Nanotubes/polyurethane-amide

Sankar

Meera

Samanta

et al. 2014

Procedia Engineering

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Section: Resultssupporting

confidence: 73%

Studies on Inter and Intra Molecular Hydrogen Bonding and Morphologies of Single-walled Carbon Nanotubes/polyurethane-amide

Sankar

Meera

Samanta

et al. 2014

Procedia Engineering

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“…The macroscopic gel stability of the hydrogels was analyzed by the reported inverted tube method and more detail gel stability test can be measured by rheometry. 31,32 The rheological properties of gel 1 were tested using oscillatory rheology and those results are collected in Fig. 1i and 1j.…”

mentioning

confidence: 99%

A novel nanostructured supramolecular hydrogel self-assembled from tetraphenylethylene-capped dipeptides

et al. 2016

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Herein, we report a tetraphenylethylene-diglycine (TPE-GG) hydrogelator from a systematic study of TPE-capped dipeptides with various amphiphilic properties. From a chemical design, we found that the hydrogelation of TPE-GG molecules can be utilized to generate supramolecular nanostructures with a large TPE-based nanobelt width (∼300 nm) and lateral dimension ratio (>30 fold). In addition, TPE-GG has the lowest molecular weight and minimum number of atoms compared to any TPE-capped peptide hydrogelator reported to date. This minimal self-assembled hydrogelator can fundamentally achieve the gel features compared with other TPE-capped peptides. A combined experimental and computational study indicates the π-π interactions, electrostatic interactions and hydrogen-bonding interactions are the major driving forces behind the formation of self-assembled nanobelts. This study demonstrates the importance of structure-property relationships and provides new insights into the design of supramolecular nanomaterials.

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“…The excess of surfactant might lyse the lipid cell membrane and denature cellular proteins causing cell death . We hypothesized that a surfactant‐free functionalization by polymer wrapping would cover the SWNT surface and therefore reduce their toxicity . To investigate whether polymer wrapping promotes the cytocompatibility of our SWNT complexes, we performed a toxicity study with the HeLa cell line.…”

Section: Resultsmentioning

confidence: 99%

“…Polymer wrapping not only preserves the photoluminescence of SWNTs but also increases their sensitivity, making polymer‐functionalized SWNTs suitable building blocks for biosensors . In addition, polymers promote the biocompatibility of SWNTs by shielding their backbones . We hypothesized that the functionalization of SWNTs with dendronized PBIs on alkylated polymers would result in water‐soluble, individualized, and biocompatible SWNT complexes applicable for bioimaging studies.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Polymer—Single‐Walled Carbon Nanotube Complexes with Charged and Noncharged Dendronized Perylene Bisimides for Bioimaging Studies

Huth

Glaeske

Achazi

et al. 2018

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Fluorescent nanomaterials are expected to revolutionize medical diagnostic, imaging, and therapeutic tools due to their superior optical and structural properties. Their inefficient water solubility, cell permeability, biodistribution, and high toxicity, however, limit the full potential of their application. To overcome these obstacles, a water-soluble, fluorescent, cytocompatible polymer-single-walled carbon nanotube (SWNT) complex is introduced for bioimaging applications. The supramolecular complex consists of an alkylated polymer conjugated with neutral hydroxylated or charged sulfated dendronized perylene bisimides (PBIs) and SWNTs as a general immobilization platform. The polymer backbone solubilizes the SWNTs, decorates them with fluorescent PBIs, and strongly improves their cytocompatibility by wrapping around the SWNT scaffold. In photophysical measurements and biological in vitro studies, sulfated complexes exhibit superior optical properties, cellular uptake, and intracellular staining over their hydroxylated analogs. A toxicity assay confirms the highly improved cytocompatibility of the polymer-wrapped SWNTs toward surfactant-solubilized SWNTs. In microscopy studies the complexes allow for the direct imaging of the SWNTs' cellular uptake via the PBI and SWNT emission using the 1st and 2nd optical window for bioimaging. These findings render the polymer-SWNT complexes with nanometer size, dual fluorescence, multiple charges, and high cytocompatibility as valuable systems for a broad range of fluorescence bioimaging studies.

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The reinforced hydrogel for drug loading: immobilization of single-walled carbon nanotubes in cross-linked polymers via multiple interactions

Cited by 19 publications

References 74 publications

Studies on Inter and Intra Molecular Hydrogen Bonding and Morphologies of Single-walled Carbon Nanotubes/polyurethane-amide

Studies on Inter and Intra Molecular Hydrogen Bonding and Morphologies of Single-walled Carbon Nanotubes/polyurethane-amide

A novel nanostructured supramolecular hydrogel self-assembled from tetraphenylethylene-capped dipeptides

Fluorescent Polymer—Single‐Walled Carbon Nanotube Complexes with Charged and Noncharged Dendronized Perylene Bisimides for Bioimaging Studies

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