After an initial burst of excitement about its extraordinary implications for our concept of space and time, the theory of general relativity underwent a thirty-year period of stagnation, during which only a few specialists worked on it, achieving little progress. In the aftermath of World War II, however, general relativity gradually re-entered the mainstream of physics, attracting an increasing number of practitioners and becoming the basis for the current standard theory of gravitation and cosmology-a process Clifford Will baptized the Renaissance of General Relativity. The recent detection of gravitational radiation by the LIGO experiment can be seen as one of the most outstanding achievements in this long-lasting historical process. In the paper, we present a new multifaceted historical perspective on the causes and characteristics of the Renaissance of General Relativity, focusing in particular on the case of gravitational radiation in order to illustrate this complex and far-reaching process.The year 2015 marked the centenary of Einstein's final formulation of the gravitational equation that bears his name, the cornerstone of the general theory of relativity. Almost exactly one hundred years after the theory's inception, the direct detection of gravitational waves through a large-scale experiment operated by the multinational LIGO Collaboration has confirmed one of its most elusive predictions. With this momentous achievement, general relativity has once again strengthened its position as the standard theory of gravitational phenomena and the basis of cosmological models, in spite of the still unresolved difficulties in reconciling Einstein's theory with quantum mechanics.The central position the theory continues to hold in our description of the physical world might not seem all that surprising, given its immediate spectacular confirmation (Eddington's solar eclipse expedition of 1919) and Einstein's subsequent rise to scientific superstardom. However, historical investigations have revealed that matters appeared quite different after the initial hype and before the current age of spectacular experimental and observational confirmations. In the early years after its formulation, the epistemic status of general relativity theory was highly uncertain in many respects, from the understanding of its physical implications to the interpretation of the impact of a choice of coordinate system on the result obtained. A perfect example of the uncertainty concerning the epistemic status of the theory is the early debate on the nature and existence of gravitational waves within the framework of general relativity. The 1916 correspondence between Einstein and the astronomers Karl Schwarzschild and Willem de Sitter reveals how confused the connections between the theory and its physical consequences were in the months following the formulation of the theory. Thanks to these epistolary exchanges, Einstein passed from believing that his gravitational theory implied the non-existence of gravitational waves to demonstrati...