The relation among steroid hormone levels, lipid profile and menopausal symptom severity

Kaya, Cihan; Cengiz, Hüseyin; Yeşil, Ali; Ekin, Murat; Yaşar, Levent

doi:10.1080/0167482x.2017.1321633

Cited by 19 publications

(23 citation statements)

References 31 publications

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“…It is possible that TSH has a direct effect on the thermoregulatory center in the brain, thus enabling the emergence of hot flashes. Other studies found no difference in the concentration of TSH in women with hot flashes and in those without them, and the same result is demonstrated by our study [14,17,24].…”

Section: Discussionsupporting

confidence: 92%

“…Øverlie et al [8] showed in their study that women with hot flashes have higher levels of androstenedione, but there was no difference in testosterone and DHEA-S levels between women with and without hot flashes. Lambrinoudaki et al [14] found no difference in testosterone and androstenedione levels between women with and without hot flashes; Kaya et al [24] showed that there was no difference in testosterone and DHEA-S levels, and similar results were shown by Ratka et al [25].…”

Section: Discussionmentioning

confidence: 67%

“…Woods et al [22] showed in their study that women with high severity hot flashes have lower levels of estrogen and higher levels of FSH. There are also studies that show no correlation between serum estradiol levels in women with hot flashes and women without them [13,14,16,17,23,24].…”

Section: Discussionmentioning

confidence: 99%

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Hot flush values of gonadotropins and estradiol in menopause

Arizanović

Vujovic²,

Ivović³

et al. 2018

Srp Arh Celok Lek

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Introduction/Objective. Hot flashes are one of the first clinical symptoms of menopause. The mechanism of hot flashes is still not fully understood. Changes in concentrations of the circulating follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen, and other hormones can lead to thermoregulatory dysfunction. The aim of this study was to examine the association between dynamic changes in concentrations of sex hormones and the presence of vasomotor symptoms in menopausal women. Methods. The study involved 36 women divided into two groups: in the first group there were 24 women with hot flashes, BMI 26.16 ? 3.42 kg/m2; the control group comprised 12 women, BMI 26.82 ? 3.89 kg/m2. Data on the presence of hot flashes were based on medical history data. Venous blood samples were collected for the analyses of FSH, LH, prolactin, estradiol, progesterone, testosterone, sex hormone binding globulin, dehidroepiandrosteron sulfate, thyroid-stimulating hormone, and thyroxin. During the subjective feeling of hot flashes, three blood samples during the day and night were collected to determine the mean levels of FSH, LH, and estradiol in women with hot flashes. Results. Women with hot flashes had significantly higher prolactin (389.58 ? 123.69 mIU/L to 258.19 ? 122 mIU/L, p < 0.01) and dehydroepiandrosterone sulfate (3.60 ? 2.49 nmol/L vs. 1.88 ? 1.27 nmol/L, p < 0.05) levels, as well as lower mean values of FSH during hot flashes during the day (69.08 ? 28.84 IU/L vs. 107.18 ? 39.11 IU/L, p < 0.01) and night (60.72 ? 21.89 IU/L vs. 104.57 ? 38.06 IU/L, p < 0.01). Conclusion. .Women with hot flashes had significantly lower mean FSH levels during hot flashes during the day and night than the control group.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 67%

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Hot flush values of gonadotropins and estradiol in menopause

Arizanović

Vujovic²,

Ivović³

et al. 2018

Srp Arh Celok Lek

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“…In addition, the levels of androgens contribute to the maintenance of genitourinary tissues expounding their role as a precursor of oestrogen biosynthesis and inducing changes in local androgen and oestrogen receptor expression, cell growth, mucin production, collagen turnover, increased perfusion, and neurotransmitter synthesis. In particular, according to recent data [5], elevated levels of tes-tosterone are related to severe psychological symptoms and total menopausal symptom scores; moreover, the decrease in progesterone levels is related to high psychological, urogenital, and total menopausal symptom scores; finally, elevated triglyceride levels are also related to the total severe symptom scores.…”

Section: Introductionmentioning

confidence: 98%

Non-oestrogenic modalities to reverse urogenital aging

Garzon

Apostolopoulos

Stojanovska

et al. 2021

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Urogenital aging is a common process affecting all women in the post-menopausal period of their life, and it is substantially due to oestrogen deprivation after ovarian function cessation. These changes can lead to a progressive, chronic, and complex association of symptoms identified as the genitourinary syndrome of menopause, which has a significant impact on quality of life. Genitourinary syndrome and urogenital aging do not resolve spontaneously and usually recur when treatment is stopped. Therefore, appropriate long-term management is of paramount importance, and local oestrogen is the most effective treatment to reverse urogenital aging and to improve symptoms of genitourinary syndrome as replacement therapy. In some women, topical oestrogen may be inconvenient, it may not achieve complete response, or it may be contra-indicated. Several non-hormonal therapies have been investigated, but few treatments have been reported as potentially able to reverse the urogenital aging process similarly to exogenous oestrogens. Laser seems the most promising, although further studies to define its safety and efficacy are mandatory. Vitamin D and E, and phytotherapy have returned conflicting results and require further confirmation. Lifestyle modifications, physiotherapy, and electrical stimulation represent inexpensive and applicable treatments that might slow urogenital aging. Among the hormonal nonoestrogenic therapies, the use of vaginal oxytocin and dehydroepiandrosterone have been found to be effective compared to placebo, as well as the use of oral ospemifene, which partially relieves vulvovaginal atrophy.

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“…Nas análises de secreção de cortisol com relação aos hábitos de saúde dos trabalhadores, mulheres que relataram utilizar anticoncepcionais apresentaram secreção significativamente menor de cortisol ao acordar (AUCg), o que está de acordo com dados da literatura (PRUESSNER et al, 1997;KAYA et al, 2017).…”

Section: Considerações Sobre Os Níveis De Cortisol Salivarunclassified

Associação da expressão circadiana do cortisol de enfermeiros segundo trabalho em turnos, estresse ocupacional e fadiga

Assis¹

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The relation among steroid hormone levels, lipid profile and menopausal symptom severity

Cited by 19 publications

References 31 publications

Hot flush values of gonadotropins and estradiol in menopause

Hot flush values of gonadotropins and estradiol in menopause

Non-oestrogenic modalities to reverse urogenital aging

Associação da expressão circadiana do cortisol de enfermeiros segundo trabalho em turnos, estresse ocupacional e fadiga

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