The relation between CT findings and sputum microbiology studies in active pulmonary tuberculosis

Ko, Jeong Min; Park, Hyun Jin; Kim, Chi Hong; Song, Seok-Whan

doi:10.1016/j.ejrad.2015.07.032

Cited by 25 publications

(20 citation statements)

References 15 publications

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“…The frequency and extent of these CT findings did not differ significantly between these two groups in our study, consistent with previous reports[4, 6, 8, 12, 14, 17]. Centrilobular micronodules and tree-in-bud appearance are the most common CT findings of active pulmonary tuberculosis[18]. Pathologically, these CT features correspond to the bronchogenic spread of caseation necrosis materials and granulomatous inflammation caused by tuberculosis[19, 20].…”

Section: Discussionsupporting

confidence: 91%

Primary multidrug-resistant tuberculosis versus drug-sensitive tuberculosis in non-HIV-infected patients: Comparisons of CT findings

Chen

et al. 2017

PLoS ONE

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BackgroundMultidrug-resistant tuberculosis has emerged as a global threat. The aim of this work was to compare the CT findings of primary multidrug-resistant tuberculosis and drug-sensitive tuberculosis in non-AIDS adults.Material and methodsFrom January 2012 to February 2016, 89 patients with primary multidrug-resistant tuberculosis were retrospectively reviewed, and 89 consecutive drug sensitive TB patients with no history of anti-tuberculous chemotherapy from January 2014 to November 2014 were enrolled as control group. All patients were seronegative for HIV. The patients’ demographic data and the locations, frequency and patterns of lung lesions on chest CT were compared.ResultsGender and frequency of diabetes were similar between the two groups. The mean age of primary multidrug-resistant tuberculosis patients was younger than that of drug-sensitive tuberculosis (39.0 vs 47.5, P = 0.005). Lung cavitary nodules or masses were more frequently observed and also showed greater extent in primary multidrug-resistant tuberculosis compared with drug-sensitive tuberculosis. The extent of bronchiectasis was significantly greater in primary multidrug-resistant tuberculosis than in drug-sensitive tuberculosis. Calcification, large nodules and calcified lymph nodes were more frequent in drug-sensitive tuberculosis.ConclusionCharacteristic chest CT findings may help differentiate between primary multi-drug resistant tuberculosis and drug-sensitive tuberculosis in patients without HIV infection.

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Section: Discussionsupporting

confidence: 91%

Primary multidrug-resistant tuberculosis versus drug-sensitive tuberculosis in non-HIV-infected patients: Comparisons of CT findings

Chen

et al. 2017

PLoS ONE

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“…Such lesions are rich in bacteria [60,160], which appear like a pellicle on the cavity wall [9], from where Mtb is expectorated. Radiologic examinations of active TB patients indicate that presence of cavities correlates with heightened abundance of bacilli in sputum [161,162]. Cavities impair efficacy of antimicrobials [163] and have been associated with development of antibiotic resistance [164] and treatment failure [165,166].…”

Section: The Way Out: the Tb Cavitymentioning

confidence: 99%

Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis

2015

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Heightened morbidity and mortality in pulmonary tuberculosis (TB) are consequences of complex disease processes triggered by the causative agent, Mycobacterium tuberculosis (Mtb). Mtb modulates inflammation at distinct stages of its intracellular life. Recognition and phagocytosis, replication in phagosomes and cytosol escape induce tightly regulated release of cytokines [including interleukin (IL)-1, tumor necrosis factor (TNF), IL-10], chemokines, lipid mediators, and type I interferons (IFN-I). Mtb occupies various lung lesions at sites of pathology. Bacteria are barely detectable at foci of lipid pneumonia or in perivascular/bronchiolar cuffs. However, abundant organisms are evident in caseating granulomas and at the cavity wall. Such lesions follow polar trajectories towards fibrosis, encapsulation and mineralization or liquefaction, extensive matrix destruction, and tissue injury. The outcome is determined by immune factors acting in concert. Gradients of cytokines and chemokines (CCR2, CXCR2, CXCR3/CXCR5 agonists; TNF/IL-10, IL-1/IFN-I), expression of activation/death markers on immune cells (TNF receptor 1, PD-1, IL-27 receptor) or abundance of enzymes [arginase-1, matrix metalloprotease (MMP)-1, MMP-8, MMP-9] drive genesis and progression of lesions. Distinct lesions coexist such that inflammation in TB encompasses a spectrum of tissue changes. A better understanding of the multidimensionality of immunopathology in TB will inform novel therapies against this pulmonary disease.

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“…So, imaging features of lung in HIV-associated nontuberculous infected patients are similar to that of bacterial infection of lung disease that brings about a challenge for diagnosis as well a delay of treatment in the clinical [12]. Compared with that of HIVassociated pulmonary tuberculosis, multiple focuses, cavity, longer course of illness and scarce lesions of lung lower lobe are observed in HIV-associated non-tuberculous pulmonary complications.…”

Section: Discussionmentioning

confidence: 74%

“…Symptoms of cavity, fibrosis, thickened pleura, calcification of lung are fund in advanced with respect of that of non-HIV infected patients [11]. In addition, as to the patients of HIV-associated pulmonary tuberculosis, millet and exudation of lesions are key features of acute case, cavity, fibrosis and calcification are characterizations of chronic ones which are rarely occurred in the clinical [12]. After M. tuberculosis infection, different HIV-associated pulmonary complications should also be detected.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Study of Fourteen AIDS-Associated Lung Complications from Imaging,Pathology and Microbiology

Xia¹,

Hu²,

Wang³

et al. 2017

J Clin Case Rep

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HIV-related pulmonary complication is a serious problem in the worldwide. In order to understand features of AIDS-associated pulmonary complications in clinical. Imaging features, microbe characterization and pathology of 14 AIDS-associated pulmonary disease patients derived from Nanyang Medical College hospitals were measured by corresponding techniques. 14 patients infected by different virus, fungus and bacteria showed special features of image and pathology, respectively. Regarding of various clinical characterizations derived from AIDS-associated pulmonary complications, combination different strategy is contributing to elucidate characterizations of AIDSassociated pulmonary complications.

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The relation between CT findings and sputum microbiology studies in active pulmonary tuberculosis

Cited by 25 publications

References 15 publications

Primary multidrug-resistant tuberculosis versus drug-sensitive tuberculosis in non-HIV-infected patients: Comparisons of CT findings

Primary multidrug-resistant tuberculosis versus drug-sensitive tuberculosis in non-HIV-infected patients: Comparisons of CT findings

Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis

Preliminary Study of Fourteen AIDS-Associated Lung Complications from Imaging,Pathology and Microbiology

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