The relation between functional magnetic resonance imaging activations and single-cell selectivity in the macaque intraparietal sulcus

dromme, Ilse Caroline Lea van; Vanduffel, Wim; Janssen, Peter

doi:10.1016/j.neuroimage.2015.03.023

Cited by 22 publications

(23 citation statements)

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“…The network of cortical areas sensitive to depth structure was remarkably extensive ( Fig 1A ). In line with previous studies [ 17 , 20 , 25 ], the anterior lateral bank of the intraparietal sulcus (IPS) was more strongly activated by curved surfaces than by flat surfaces at different disparities. However, in contrast to previous investigations [ 20 , 22 ], we also observed additional activations in the caudal IPS region—comprising both the lateral and the medial bank of the caudal IPS.…”

Section: Resultssupporting

confidence: 89%

“…We calculated the interaction between the factors “curvature” and “disparity” on the group data (using 89 runs for each monkey), by computing the contrast [CS–CC]–[FS–FC], where CS = curved stereo, CC = curved control, FS = flat stereo and FC = flat control. As in previous studies [ 20 , 22 , 25 ], this contrast aims to identify regions that are activated more strongly by curved stimuli (compared to their control stimuli) than by flat stimuli (compared to their control stimuli) presented at different disparities.…”

Section: Resultsmentioning

confidence: 99%

“…Since electrical microstimulation of AIT neurons has a profound and predictable effect on depth structure categorization [ 30 ], the most likely route through which CIP inactivation influenced depth structure categorization is through AIT. It is important to emphasize that a number of single-cell studies have already characterized the depth structure selectivity of individual neurons in almost all nodes of this network in great detail: in AIT [ 21 , 24 , 28 , 30 , 64 ], AIP [ 23 , 25 , 65 ], F5a [ 29 , 52 ], and CIP [ 47 ]. Despite the inherent assumptions associated with fMRI [ 25 ], these single-cell studies provide strong support for the notion that the curvature x disparity interaction contrast we used is effectively an fMRI indicator of higher-order disparity sensitivity at the neuronal level.…”

Section: Discussionmentioning

confidence: 99%

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Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision

et al. 2016

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The primate visual system consists of a ventral stream, specialized for object recognition, and a dorsal visual stream, which is crucial for spatial vision and actions. However, little is known about the interactions and information flow between these two streams. We investigated these interactions within the network processing three-dimensional (3D) object information, comprising both the dorsal and ventral stream. Reversible inactivation of the macaque caudal intraparietal area (CIP) during functional magnetic resonance imaging (fMRI) reduced fMRI activations in posterior parietal cortex in the dorsal stream and, surprisingly, also in the inferotemporal cortex (ITC) in the ventral visual stream. Moreover, CIP inactivation caused a perceptual deficit in a depth-structure categorization task. CIP-microstimulation during fMRI further suggests that CIP projects via posterior parietal areas to the ITC in the ventral stream. To our knowledge, these results provide the first causal evidence for the flow of visual 3D information from the dorsal stream to the ventral stream, and identify CIP as a key area for depth-structure processing. Thus, combining reversible inactivation and electrical microstimulation during fMRI provides a detailed view of the functional interactions between the two visual processing streams.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision

et al. 2016

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“…Similarly, posterior AIP and DIPSA share 6 of 8 characteristics. Significantly, combined single-cell and fMRI experiments in monkey [ 47 ] suggest that 3D SFD activations in DIPSA and DIPSM actually correspond to two neuronal clusters selective for 3D SFD in the rostral lateral bank of monkey IPS. This underscores how parallel imaging in humans and NHP disclose neuronal operations in the human brain.…”

Section: Similarities Along the Intraparietal Sulcusmentioning

confidence: 99%

Functional definitions of parietal areas in human and non-human primates

Orban¹

2016

Proc. R. Soc. B.

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Establishing homologies between cortical areas in animal models and humans lies at the heart of translational neuroscience, as it demonstrates how knowledge obtained from these models can be applied to the human brain. Here, we review progress in using parallel functional imaging to ascertain homologies between parietal areas of human and non-human primates, species sharing similar behavioural repertoires. The human homologues of several areas along monkey IPS involved in action planning and observation, such as AIP, LIP and CIP, as well as those of opercular areas (SII complex), have been defined. In addition, uniquely human areas, such as the tool-use area in left anterior supramarginal gyrus, have also been identified.

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“…Non-human primate fMRI studies have consistently shown strong activity in the parietal cortex during 3D perception in the presence disparities (Durand et al, 2007; Joly et al, 2009; Rosenberg et al, 2013; Rosenberg and Angelaki, 2014; Taira et al, 2000; Tsao et al, 2003; Tsutsui et al, 2002; Van Dromme et al, 2016, 2015; Verhoef et al, 2015). However, only a few fMRI studies (e.g., Chandrasekaran et al, 2007; Durand et al, 2009; Georgieva et al, 2009; Minini et al, 2010; Tsao et al, 2003) have examined the processing of 3D shape from binocular disparity in parietal cortex in humans.…”

Section: Introductionmentioning

confidence: 99%

Dissociating neural activity associated with the subjective phenomenology of monocular stereopsis: an EEG study

Uji

Jentzsch

Redburn

et al. 2019

Preprint

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Abstracts 1The subjective phenomenology associated with stereopsis, of solid tangible objects separated 2 by a palpable negative space, is conventionally thought to be a by-product of the derivation of 3 depth from binocular disparity. However, the same qualitative impression has been reported 4 in the absence of disparity, e.g., when viewing pictorial images monocularly through an 5 aperture. Here we aimed to explore if we could identify dissociable neural activity associated 6 with the qualitative impression of stereopsis, in the absence of the processing of binocular 7 disparities. We measured EEG activity while subjects viewed pictorial (non-stereoscopic) 8 images of 2D and 3D geometric forms under four different viewing conditions (Binocular, 9 Monocular, Binocular aperture, Monocular aperture). EEG activity was analysed by 10 oscillatory source localization (beamformer technique) to examine power change in occipital 11 and parietal regions across viewing and stimulus conditions in targeted frequency bands 12 (alpha: 8-13Hz & gamma: 60-90Hz). We observed expected event-related gamma 13 synchronization and alpha desynchronization in occipital cortex and predominant gamma 14 synchronization in parietal cortex across viewing and stimulus conditions. However, only the 15 viewing condition predicted to generate the strongest impression of stereopsis (monocular 16 aperture) revealed significantly elevated gamma synchronization within the parietal cortex for 17 the critical contrasts (3D vs. 2D form). These findings suggest dissociable neural processes 18 specific to the qualitative impression of stereopsis as distinguished from disparity processing. 19 20 Keywords 21 Stereopsis, Monocular aperture, EEG, qualitative impression, parietal cortex, gamma 22 synchronization 23 1 Ames, A., 1925.

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The relation between functional magnetic resonance imaging activations and single-cell selectivity in the macaque intraparietal sulcus

Cited by 22 publications

References 57 publications

Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision

Posterior Parietal Cortex Drives Inferotemporal Activations During Three-Dimensional Object Vision

Functional definitions of parietal areas in human and non-human primates

Dissociating neural activity associated with the subjective phenomenology of monocular stereopsis: an EEG study

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