The purpose of this study was to examine the relation from various forms of microaggressions (i.e., lesbian, gay, bisexual, transgender, queer, plus [LGBTQ+] racism, person of color heterosexism and immigrant objectification) to posttraumatic stress disorder (PTSD) symptoms and psychological distress among sexual minority Latinx people, while exploring the potential protective role of three forms of collective action (i.e., anti-racist, sexual minority, and immigrant rights). Specifically, we hypothesized that microaggressions would be uniquely positively related to both PTSD symptoms and psychological distress, while the three forms of collective action would be uniquely negatively related to these psychological outcomes. Moreover, we hypothesized that collective action would moderate (i.e., buffer) the positive associations between microaggressions and psychological outcomes. Among a sample of 364 sexual minority Latinx individuals, results suggested that each form of microaggression was uniquely positively associated with both PTSD symptoms and psychological distress, although collective action was not significantly related to these outcomes. Anti-racist collective action buffered the relations from LGBTQ+ racism to PTSD symptoms and psychological distress, while immigrant rights collective action exacerbated the positive relation between immigrant objectification to psychological distress. Results from this study point to the importance of exploring multiple forms of microaggressions when understanding the mental health needs of sexual minority Latinx people.