The Relation between Glycated Hemoglobin and Severity of Coronary Artery Disease in Non-Diabetic Patients with acute coronary syndrome.

Ijar, Journal; Bastawesy, Reda B; Abdelmoniem, Ahmed M.; Abdel‐Kader, Mahmoud H.; Reda,

doi:10.21474/ijar01/2663

Cited by 6 publications

(3 citation statements)

References 2 publications

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“…Glycated haemoglobin (HbA1c) is widely acknowledged as a pivotal and more accurate criterion for pre-empting the severity of DM over fasting glucose levels [4]. HbA1c levels offer more advantage by providing a stable index of long-term glycemic status, which is related to two to three months of average glucose concentration in plasma [5]. Elevated HbA1c levels are notably linked to severe coronary artery atherosclerosis [6-7].…”

Section: Introductionmentioning

confidence: 99%

“…The American Diabetes Association, in its recent position statement, stated that lowering HbA1c may be associated with a reduction in the microvascular, neuropathic, and possibly macrovascular complications of DM [8]. Similarly, since 2004, in non-diabetics, studies linking the relation between the severity of CAD and cardiovascular mortality with HbA1c levels have been widely conducted [5]. Further, they provide evidence that the risk for developing CAD is significantly higher with elevated HbA1c levels even within the normal range [9].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Glycated Hemoglobin A1c in Determining the Severity of Coronary Artery Disease in Diabetic and Non-Diabetic Subjects in Karachi

Ul-Haque

Deen

Shafique

et al. 2019

Cureus

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Introduction Coronary artery disease is the leading cause of death worldwide by incidence. Over the years, many studies have been conducted to find predictors of coronary artery disease; however, in the last few decades, the level of HbA1c in diabetics has been investigated as a potential predictor. Our study offers additional insight by investigating similar relationships in non-diabetic patients and by investigating potential predictors more comprehensively, making it the first of its kind study. The aim of our study is to indicate that rising HbA1c levels suggest that there’s a greater risk of coronary artery disease, which can further be confirmed by the SYNTAX score, degree of stenosis, and numbers of vessels involved. Methods Data from 177 diabetic and 378 non-diabetic patients, all of whom were above 18 years of age, were included in the research. HbA1c levels (>5.6%), SYNTAX score, hypertension, number of vessels involved, and other demographic elements, such as age, smoking, and body measurements, were calculated and compared for diabetics and non-diabetics. Results HbA1c was higher in comparison to non-diabetic subjects (p <0.001). Age >53 was found to be a predictor for SYNTAX score ≥23 in diabetic patients (p <0.05). Male gender and smoking were found to be independent predictors for three-vessel disease in the non-diabetic population (p-value<0.05). There was no significant relationship between the SYNTAX score and HbA1c levels in non-diabetics (p=0.885) and diabetics. In conclusion, there is no correlation between elevated HbA1c levels and SYNTAX score ≥23.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Glycated Hemoglobin A1c in Determining the Severity of Coronary Artery Disease in Diabetic and Non-Diabetic Subjects in Karachi

Ul-Haque

Deen

Shafique

et al. 2019

Cureus

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“…The study conducted by other authors in Bangladesh found that male are predominant. [33][34][35][36] Regarding CAD risk factors in this study, smoking, diabetes mellitus, hypertension, family history of CAD, dyslipidemia, and obesity, did not differ significantly between patients with High risk and Low risk group.…”

Section: Discussionmentioning

confidence: 90%

Evaluation of the Glycosylated Haemoglobin as a Predictor of Severity of Coronary Artery Disease in Non-diabetic NSTEMI Patients

et al. 2022

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Background: Glycated hemoglobin (HbA1c) values reflect two to three months average endogenous exposure haemoglobin to glucose including postprandial spikes and have low intra-individual variability particularly in non-diabetic patients. Elevated HbA1c is regarded as an independent risk factor for coronary artery disease (CAD) in patients with or without diabetes mellitus (DM). The purpose of this study is to determine the correlation between the level of HbA1c and the severity of coronary artery disease in non-diabetic non ST elevation myocardial infarction (NSTEMI) patients. Methods: This observational study was carried out with total of 64 non-diabetic patients with a history of NSTEMI. Patients were divided into 2 groups based on HbA1c - one group having HbA1c ³5.7 – 6.4% (High risk group) and another group with HbA1c < 5.7% (Low risk group). Severity of CAD was assessed using Gensini score derived from coronary angiographic data. Gensini score < 36 points was regarded as mild coronary artery disease and Gensini score 36 points as moderate to severe coronary artery disease. Then patients with high and low risk HbA1C groups were correlated with severity of CAD. Results: Over 55.5% patients with HbA1c in high-risk group (5.7 – 6.4%) had severe CAD as opposed to 28.6% patients with HbA1c in low-Risk group (<5.7%). The individuals with high-risk group of HbA1c was 3.1 (95% of CI = 1.1 – 8.9) times more likely to have severe CAD than those with HbA1c < 5.7% (p = 0.031). Spearman correlation between HbA1c and Gensini score depicted that the two variables exhibit a linear relationship indicating that Gensini score rises parallel with the rise of HbA1c (r = 0.289, p = 0.021). Conclusion: The study concluded that over half of the non-diabetic, NSTEMI patients with high-risk range HbA1c are likely to have severe CAD than those with HBA1c within normal range. Cardiovasc j 2022; 15(1): 26-35

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The use of glycosylated hemoglobin (HbA1c) as a predictor of the severity of acute coronary syndrome among diabetic patients

2020

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The Relation between Glycated Hemoglobin and Severity of Coronary Artery Disease in Non-Diabetic Patients with acute coronary syndrome.

Cited by 6 publications

References 2 publications

The Role of Glycated Hemoglobin A1c in Determining the Severity of Coronary Artery Disease in Diabetic and Non-Diabetic Subjects in Karachi

The Role of Glycated Hemoglobin A1c in Determining the Severity of Coronary Artery Disease in Diabetic and Non-Diabetic Subjects in Karachi

Evaluation of the Glycosylated Haemoglobin as a Predictor of Severity of Coronary Artery Disease in Non-diabetic NSTEMI Patients

The use of glycosylated hemoglobin (HbA1c) as a predictor of the severity of acute coronary syndrome among diabetic patients

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