The relation between intracranial and intraocular pressures: Study of 50 patients

Sajjadi, S. Ahmad; Harirchian, Mohammad Hossein; Sheikh‐Bahaei, Nasim; Mohebbi, Maryam; MalekMadani, Mohammad Hossein; Saberi, Hooshang

doi:10.1002/ana.20856

Cited by 61 publications

(72 citation statements)

References 16 publications

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“…30 Classically, PTC is more commonly observed in overweight women of reproductive age. 24 The incidence of PTC in women who are between 20 and 44 years of age and 20% above ideal body weight increases to 19.3 cases per 100,000 population; the odds ratio of PTC increases from 6.5 for a BMI of 25-29 to 26.0 for a BMI of Ͼ35. 28,31 Obesity has long been associated with the development of PTC.…”

Section: Review Articlementioning

confidence: 99%

“…23 Anatomic connections between the cranial fossa and orbit are thought to explain why ICP directly correlates with IOP. 24 Absence of papilledema has been reported in many populations of patients with IIH, but its absence may be more suggestive of an alternative etiology for headache and vision loss. 19 Other funduscopic findings that may be seen in PTC are choroidal folds, parallel striae of alternating yellow crests, and darker troughs; choroidal folds compromise vision and can be seen with elevated ICP, even when papilledema has resolved.…”

Section: Clinical Syndromementioning

confidence: 99%

“…[66][67][68] Globe flattening may be explained by the direct correlation between elevated ICP and IOP via the transmission of elevated CSF pressure through the subarachnoid space, extending through the ONS to the posterior globe. 24 One possible confounding explanation for posterior sclera flattening is its detection in the context of ocular hypotony; however, this condition is more rare, and this neuroimaging finding is more likely to be indicative of intracranial hypertension. 68,69 Intraocular protrusion (Fig 3) is thought to occur in a manner similar to posterior globe flattening and is another sign associated with PTC.…”

Section: Mr Imagingmentioning

confidence: 99%

“…54 Some groups propose the use of venous sinus stent placement to treat IIH on the basis of several imaging studies showing stenosis of the cerebral venous sinuses and the presumption that venous outflow obstruction constitutes the underlying etiology of most cases of IIH. 24,55 One group at the University of Cambridge reported success with 5 of 12 patients rendered asymptomatic and 4 of 8 patients demonstrating resolution of papilledema after venous sinus stent placement. 55 Conversely, another group cited 3 cases of restenosis to counter the belief that stent placement is a universally applicable procedure in IIH; they argued that stenosis in IIH may be the result of the elevated ICP itself and not the cause of the increased ICP.…”

mentioning

confidence: 99%

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Pseudotumor Cerebri: Brief Review of Clinical Syndrome and Imaging Findings

Degnan

Levy

2011

AJNR Am J Neuroradiol

246

179

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SUMMARY: PTC is a clinical entity of uncertain etiology characterized by intracranial hypertension. The syndrome classically manifests with headaches and visual changes in women with obesity. Traditionally, imaging ruled out secondary causes of elevated CSF pressure but now may reveal findings frequently seen in patients with PTC, including the following: flattening of the globe, an empty sella, an enlarged ONS, protrusion and enhancement of the optic nerve head, and increased tortuosity of the optic nerve. Novel imaging methods, including MR venography, have additionally identified sinovenous stenosis as a potential indicator of PTC.ABBREVIATIONS: BMI ϭ body-mass index; CN ϭ cranial nerve; HIV ϭ human immunodeficiency virus; ICP ϭ intracranial pressure; IIH ϭ idiopathic intracranial hypertension; ISF ϭ interstitial fluid; MRI ϭ MR imaging; ONS ϭ optic nerve sheath; ONSF ϭ optic nerve sheath fenestration; IOP ϭ intraocular pressure; PCOS ϭ polycystic ovary syndrome; PTC ϭ pseudotumor cerebri syndrome

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Section: Review Articlementioning

confidence: 99%

Section: Clinical Syndromementioning

confidence: 99%

Section: Mr Imagingmentioning

confidence: 99%

mentioning

confidence: 99%

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Pseudotumor Cerebri: Brief Review of Clinical Syndrome and Imaging Findings

Degnan

Levy

2011

AJNR Am J Neuroradiol

246

179

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“…This suggests a posture-dependent change in TLCPD. However, simultaneous assessment of the IOP and ICP is sparse [17][18][19][20] . Changes in TLCPD as a function of posture has not yet been studied.…”

Section: Introductionmentioning

confidence: 99%

The pressure difference between eye and brain changes with posture

Eklund

Jóhannesson

Johansson

et al. 2016

Annals of Neurology

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Objective: The discovery of a posture-dependent effect on the difference between intraocular pressure (IOP) and intracranial pressure (ICP) at the level of lamina cribrosa could have important implications for understanding glaucoma and idiopathic intracranial hypertension and could help explain visual impairments in astronauts exposed to microgravity. The aim of this study was to determine the postural influence on the difference between simultaneously measured ICP and IOP.Methods: Eleven healthy adult volunteers (age 46±10 years) were investigated with simultaneous ICP, assessed through lumbar puncture, and IOP measurements when supine, sitting, and in 9° head down tilt (HDT). The trans-lamina cribrosa pressure difference (TLCPD) was calculated as the difference between the IOP and ICP. To estimate the pressures at the lamina cribrosa, geometrical distances were estimated from MRI and were used to adjust for hydrostatic effects. Results:The TLCPD (mm Hg) between IOP and ICP was 12.3±2.2 for supine, 19.8±4.6 for sitting and 6.6±2.5 for HDT. The expected 24-hour average TLCPD on earthassuming 8 h supine and 16 h upright-was estimated to be 17.3 mm Hg. By removing the hydrostatic effects on pressure, a corresponding 24 h-average TLCPD in microgravity environment was simulated to be 6.7 mmHg. Interpretation:We provide a possible physiological explanation for how microgravity can cause symptoms similar to those seen in patients with elevated ICP. The observed posture dependency of TLCPD also implies that assessment of the difference between IOP and ICP in upright may offer new understanding of the pathophysiology of idiopathic intracranial hypertension and glaucoma.

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Wearable and Implantable Intraocular Pressure Biosensors: Recent Progress and Future Prospects

Yang

Huang

et al. 2021

Advanced Science

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Biosensors worn on or implanted in eyes have been garnering substantial attention since being proven to be an effective means to acquire critical biomarkers for monitoring the states of ophthalmic disease, diabetes. Among these disorders, glaucoma, the second leading cause of blindness globally, usually results in irreversible blindness. Continuous intraocular pressure (IOP) monitoring is considered as an effective measure, which provides a comprehensive view of IOP changes that is beyond reach for the “snapshots” measurements by clinical tonometry. However, to satisfy the applications in ophthalmology, the development of IOP sensors are required to be prepared with biocompatible, miniature, transparent, wireless and battery‐free features, which are still challenging with many current fabrication processes. In this work, the recent advances in this field are reviewed by categorizing these devices into wearable and implantable IOP sensors. The materials and structures exploited for engineering these IOP devices are presented. Additionally, their working principle, performance, and the potential risk that materials and device architectures may pose to ocular tissue are discussed. This review should be valuable for preferable structure design, device fabrication, performance optimization, and reducing potential risk of these devices. It is significant for the development of future practical IOP sensors.

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The relation between intracranial and intraocular pressures: Study of 50 patients

Abstract: IOP is correlated with ICP.

Cited by 61 publications

References 16 publications

Pseudotumor Cerebri: Brief Review of Clinical Syndrome and Imaging Findings

Pseudotumor Cerebri: Brief Review of Clinical Syndrome and Imaging Findings

The pressure difference between eye and brain changes with posture

Wearable and Implantable Intraocular Pressure Biosensors: Recent Progress and Future Prospects

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