The relation between intraocular pressure peak in the water drinking test and visual field progression in glaucoma

Abstract

Aim: To compare the results of the water drinking test between glaucomatous eyes with and without visual field progression. Methods: Retrospective analysis of 76 eyes of 76 open angle glaucoma patients followed for a mean period of 26.0 (SD 13.8) months. Patients were submitted to the water drinking test at the beginning of the follow up period. Reliable achromatic automated perimetry tests performed during the studied period were used to characterise visual field progression. All subjects were under clinical therapy and had an intraocular pressure (IOP) lower than 17 mm Hg monitored by isolated measurements during the follow up period. The results of the water drinking test were compared between glaucomatous eyes with and without visual field progression. Results: Twenty eight eyes reached definite visual field progression. There were no significant differences in the mean age, sex, race, basal IOP, number of antiglaucomatous drugs, initial mean deviation (MD), and corrected pattern standard deviation (CPSD) between eyes that showed visual field progression and the ones who did not progress. A significant difference of 1.9 (SD 0.6) mm Hg (p = 0.001, analysis of covariance; 95% CI 0.8 to 3.0) was observed between glaucomatous eyes that showed visual field deterioration and glaucomatous eyes that did not progress. A significant difference of 16.8% (SD 4.6%) in the mean percentage of IOP variation was also observed between the two groups (p,0.001, analysis of covariance; 95% CI 7.7 to 26.0). Conclusions: Mean IOP peak and percentage of IOP variation during water drinking test were significantly higher in patients with visual field progression compared with patients who did not progress.

Intraocular pressure fluctuation in healthy and glaucomatous eyes: a comparative analysis between diurnal curves in supine and sitting positions and the water drinking test

“…This variation may help explain the weak IOP correlations found between the sitting and supine positions. According to Mosaed et al, the IOP data variations during both practice hours and night hours for non-treated glaucoma patients have been considered clinically relevant (12,16) . A DTC gives a better estimate of an individual's IOP level and fluctuations than a single measurement during an office visit, but demands hospital admission where IOP can be measured over 24 hours.…”

Choroidal thickness variation in highly myopic eyes during the water drinking test

“…The results of the WDT have been shown to correlate well with intraocular pressure (IOP) peaks occurring during daytime (13) . A correlation between WDT results and progression of glaucoma has also been demonstrated (14,15) . The choroid has been studied due to its potential role in the pa thogenesis (16) of glaucoma, with several authors attempting to determine the relationship between glaucoma and CT (17)(18)(19)(20)(21)(22) .…”

The Effect of Water Drinking Test on the Corneal Biomechanical Properties and Central Corneal Thickness in Patients with Glaucoma Suspect

“…Son zamanlarda, su içme testinin, diurnal basınç eğrisinin GİB pik değerlerini tahmin etmek amacıyla pratik bir metot olduğu önerilmektedir. 30,31 Önceki çalışmalarda, diurnal tansiyon eğrisi ile su içme testi arasında anlamlı korelasyon olduğu gösterilmiştir. 32,33 Sağlıklı bireylerde günlük GİB değişimi ortalama 3-5 mmHg arasındadır.…”