The relation between levels of selected PCB congeners in human serum and follicular fluid

Pauwels, An; Covaci, Adrian; Delbeke, L.; Punjabi, Usha; Schepens, Paul

doi:10.1016/s0045-6535(99)00170-8

Cited by 43 publications

(21 citation statements)

References 13 publications

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“…These results are significant since the levels of persistent organic pollutants in follicular fluid have been reported to be similar to those in the serum [51]. Moreover, PCB 153, as a major and very stable PCB congener, has been shown to correlate directly to the total amounts of PCBs [31].…”

Section: Pcbs and Oocyte Maturationmentioning

confidence: 66%

“…It was Trapp [30] who first demonstrated the presence of these chlorinated hydrocarbons in the follicular fluid of women (in a mean of 553 ng/g) and highlighted the potential threat to reproductive health posed by these contaminants. Since then several study reported the presence of PCBs in human follicular fluid in concentrations up to 1600 ng/g [31][32][33]. Furthermore, PCBs have been detected in human ovarian tissue [34], human embryos and fetuses [35].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of endocrine disrupters on ovarian function and embryonic development

Gandolfi

Pocar²,

Brevini

et al. 2002

Domestic Animal Endocrinology

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Section: Pcbs and Oocyte Maturationmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Impact of endocrine disrupters on ovarian function and embryonic development

Gandolfi

Pocar²,

Brevini

et al. 2002

Domestic Animal Endocrinology

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“…It is important to note that the concentration range used in these studies is comparable to that observed in the serum of nonexposed women (0.001 and 0.4 ng g −1 for PCBs 126 and 153, respectively; Johansen et al, 1994), which, in turn, is similar to the concentrations of persistent organic pollutants in follicular fluid (Kimbrough, 1995). Moreover, PCB 153, as a major and very stable PCB congener, has been shown to correlate directly with the total amounts of PCBs (Pauwels et al, 1999). However, at present, no data are available on the PCB concentrations present either in cattle serum or follicular fluid.…”

Section: Oocyte Maturationmentioning

confidence: 99%

The impact of endocrine disruptors on oocyte competence

Pocar¹,

Brevini²,

Fischer³

et al. 2003

Reproduction

103

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To date, approximately 60 chemicals have been identified as endocrine disruptors: exogenous agents that interfere with various aspects of natural hormone physiology. The potential reproductive and health hazards of these environmental chemicals have recently generated concern among the scientific community, policy makers and general public. The present review presents and discusses the available evidence that environmental chemicals are causing ovarian toxicity in various species, with particular attention to farm animals. The impact of chronic exposure to endocrine disruptors via food and drinking water cannot be neglected when studying fertility problems in these species. This review focuses attention on the superfamily of organochlorine chemicals, persistent organic pollutants (POPs), because of their persistence in the environment, ability to concentrate up the food chain, continued detection in environmental matrices and ability to be stored in the adipose tissue of animals and humans. Published data clearly indicate that POPs disrupt mammalian oocyte maturation and follicle physiology in every species studied so far, including farm animals. However, as most of the data available still derive from experiments performed on laboratory species or in vitro models, great care should be taken when extrapolations to other species or environmental situations are attempted.

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“…[1][2][3][4] Body fluids and tissues were commonly in use to characterize human exposure of POPs. [5][6][7] This approach results in integrative description of exposure in the past without enabling us to identify distinct body burdens. In recent years, hair analysis has rapidly progressed as a useful method for detecting and monitoring POPs over the long term.…”

Section: Introductionmentioning

confidence: 99%

Determination of Persistent Organochlorine Pollutants in Rat Hair by Gas Chromatography-Mass Spectrometry

2004

Bulletin of the Korean Chemical Society

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A gas chromatography/mass spectrometric assay method was developed for the determination of persistent organochlorine pollutants (POPs) in hair. For the exact extraction study was used hair of rat exposed with POPs. Sonication of the hair matrix with 3 M HCl solution in methylene chloride of the extraction methods studied was the most efficient and rapid sample preparation method. After sonication of rat hair was achieved clean up with a solid phase extraction procedure using silica gel-florisil. Elution was performed with 8 mL of methylene chloride. The eluate was concentrated to approximately 100 µL and analyzed by gas chromatography-mass spectrometry (GC-MS). Detection limits of POPs were in the concentration range of 0.6-1.2 ng/g in rat hair. Aldrin, dieldrin, p,p-DDT and mirex were dosed rat for 4 weeks at concentration of 0.01 mg/L in drinking water and detected in rat hair at concentration of 2.8, 11.3, 7.9 and 15.6 ng/g, respectively. Aldrin and p,p-DDT were metabolized to dieldrin and p,p-DDE, which were detected in concentration of 9.7 and 2.9 ng/g in rat hair, respectively. The developed method may be valuable to be used to analyze POPs in human hair.

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The relation between levels of selected PCB congeners in human serum and follicular fluid

Cited by 43 publications

References 13 publications

Impact of endocrine disrupters on ovarian function and embryonic development

Impact of endocrine disrupters on ovarian function and embryonic development

The impact of endocrine disruptors on oocyte competence

Determination of Persistent Organochlorine Pollutants in Rat Hair by Gas Chromatography-Mass Spectrometry

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