The Relation between <i>Helicobacter Pylori</i> Infection and Hepatocellular Carcinoma in Egyptian Patients

Abstract

This work to show the relation between Helicobacter Pylori infection and Hepatocellular Carcinoma in Egyptian patients. This study was completed at National liver institute in Egypt. Patients in this study were recognized cases of chronic Hepatitis C virus liver disease with and without hepatocellular carcinoma. Serum samples of patients of hepatocellular carcinoma with hepatitis C Virus (HCV) of 40 male and 30 female adults had been collected, Helicobacter pylori (H. pylori) was detected by enzyme linked immunosorbent assay with comparison with ten males and ten females patients as control groups with chronic Hepatitis C Virus (HCV) without HCC. All patients were free from hepatitis B virus (HBV) infection, without cigarette smoking and without alcohol drinking. Positive H. pylori was found more in male and female patients with hepatocellular carcinoma combined by chronic HCV than those with HCV without hepatocellular carcinoma and there was significant difference between both groups. There is a significant association between infection with H. pylori, elevated titers of H. pylori antibodies and the increased risk of hepatocellular carcinoma in males and females Egyptian patients.

Association between Severity of Liver Disease, Frequency of Helicobacter pylori Infection, and Degree of Gastric Lesion in Egyptian Patients with Hepatitis B Virus Infection

“…The International Agency for Research on Cancer in 1994 classified H. pylori as a type I carcinogenic element. 11 Several studies examined H. pylori infection and gastric endoscopic lesions in cirrhotic patients. They found H. pylori in 60% and 60.7% of the patients, 12,13 respectively.…”