The relation between osteoporosis of the spine and osteoarthritis of the knee

Yokozeki, Hiroo; Igarashi, Mitsuo; Karube, Shunji; Shiraki, Masataka; Kurokawa, Takahide

doi:10.1007/bf00181109

Cited by 12 publications

(8 citation statements)

References 6 publications

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“…Hart et al 6 reported a small, but significant, increase in BMD in middle-aged women with osteoarthritis of the knee. Yokozeki et al, 20 investigating the relationship between osteoporosis of the spine and osteoarthritis of the knee, showed that the BMD was significantly higher in those with severe osteoarthritis than in normal patients, but Malluche et al 19 observed osteoporosis in all of their 12 patients who had had total knee arthroplasty for degenerative arthritis. Burr et al, 17 in a study of the skeletons of Eskimos, identified sex-dependent links between the bone mineral content of the midshaft of the tibia and osteoarthritis of the tibia; in women the level was low whereas in men it was high.…”

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confidence: 99%

“…15,16 There have, however, been relatively few studies in patients with osteoarthritis of the knee. [17][18][19][20] The association between bone mineral density (BMD) and osteoarthritis of the knee is uncertain. Hannan et al 18 found in women that the femoral BMD was higher in those with osteophytes at the knee than in those without and was not necessarily associated with narrowing of the joint space.…”

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confidence: 99%

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The influence of osteoporosis on varus osteoarthritis of the knee

Terauchi

Shirakura

Katayama

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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W e studied 37 patients with varus osteoarthritis of the knee to determine the influence of the bone mineral density (BMD) on the varus deformity. There were 15 men (21 knees) and 22 women (38 knees). The mean age of the men was 69 years and of the women 68 years. BMD was measured in the L1-L4 spinal region using dual X-ray absorptiometry. In the women a low level of BMD was associated with varus deformity originating at the proximal tibia, but a high level was predominantly linked with deformity originating in the joint space. Similar findings were obtained in the men. Our results suggest that a low BMD predisposes to trabecular microfractures and consequently increased stress on the articular cartilage. A low BMD does not preclude osteoarthritic change in the knee.

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The influence of osteoporosis on varus osteoarthritis of the knee

Terauchi

Shirakura

Katayama

et al. 1998

The Journal of Bone and Joint Surgery. British volume

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“…Increased bone mass has even been proposed as an independent risk factor for OA (Radin and Rose, 1986;Boyde et al, 1995;Dalle Carbonare et al, 2000). Recent studies have indicated higher BMD in subjects with OA at a distant site (Yokozeki et al, 1995;El Miedany et al, 2000;Naitou et al, 2000), but suggested less of an association with hand OA (Sambrook and Naganathan, 1997). Antoniades et al (2000) found no clear association between hip OA and BMD either at the contralateral site, in the lumbar spine, or throughout the entire body.…”

Section: Discussionmentioning

confidence: 99%

“…The possible inverse relationship between OP and OA has long been discussed in the literature (Yokozeki et al, 1995;Burger et al, 1996;Sambrook and Naganathan, 1997;Dequeker, 1999), but it is still not clear whether and to what extent this covariation exists within the individual and at the population level. If the intraindividual covariation exists, it may indicate that various aspects of skeletal tissue degeneration occurred simultaneously in the same individual.…”

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Interrelationship between bone aging traits and basic anthropometric characteristics

Kalichman

Kobyliansky

Livshits

2002

American J Hum Biol

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Using plain hand radiographs, the age dependence of various bone-aging traits (bone mineral density [BMD], cortical index [CI], osteoarthritis [OA], and osseographic [OSS] scores) was evaluated to test whether the correlation among these traits is an individual- or population-based phenomenon. In addition, the effect of anthropometric features on variation of bone-aging traits was estimated. The study included 1,295 individuals from Chuvasha, Russia, 18 to 89 years. BMD was measured from the compact compartment of the middle and distal phalanges of both 3(rd) fingers. The CI of the II-IV metacarpal bones and II-IV proximal phalanges was obtained. The development of OA was based on the standard Kellgren and Lawrence grading scheme for 28 hand joints. OSS score, a surrogate measure that takes into account different kinds of bone changes, was also obtained for each individual. Body weight and height, eight skinfold thicknesses on the trunk and extremities, and breadths of the long bones were measured. Sex-based univariate analyses and multivariate statistical analysis showed the following: 1) Age dependence was defined more strongly in "OA-linked" compared to "osteoporosis (OP)-linked" traits; 2) While "OP-linked" bone-aging traits correlated with age differently between sexes, "OA-linked" traits did not; 3) The strong interrelationship between OA-linked and OP-linked traits in both sexes became very weak and statistically insignificant (P > 0.10) after adjustment for age. Thus, OA and OP conditions in the same individual develop independently and probably reflect different underlying physiological mechanisms. 4) Anthropometric characteristics were significantly correlated with bone-aging traits, but correlations were low (r < 0.20). Thus, the contribution of anthropometric characteristics to the rate and pattern of bone aging of the hand was to relatively small.

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“…The association of OAK and osteoporosis was also reported. 3,4 Terauchi et al 5 reported that osteoporosis causes trabecular microfractures, thus increasing the stresses on the cartilage and thereby increasing the severity of OAK. Ding et al 6 showed in a study involving 10 cadavers that even in early OAK, deterioration in the architecture of cancellous bone in the sub-chondral proximal tibia decreases mechanical properties.…”

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High-Resolution Peripheral Quantitative Computed Tomography (HR-PQCT) and Dual Energy X-Ray Absorptiometry (DXA) Measurements of Proximal Tibia in Patients Undergoing Total Knee Arthroplasty

Sadat-Ali

Al-Omran

2016

International Surgery

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The aim of the study was to assess bone morphometric indices of the proximal tibia and compare it with bone mineral density (BMD) at hip and lumbar spine and compare with the pQCT. Fifty consecutive patients who underwent total knee arthroplasty (TKA) had a dual energy X-ray absorptiometry (DXA) scan of the upper femur and lumbar spine. Upper tibial cuts were harvested from the tibial condyles and a DXA of tibial cuts was done during TKA. Bone morphometry studies were carried out using HR-pQCT. The bone mineral density at the hip was 0.54 6 0.08 g/cm 2 and spine was 0.73 6 0.1 with a T score at the hip À2.23 6 0.44 and spine À2.61 6 0.45. The bone mineral density of the tibial cut was 0.356 6 0.03 g/cm 2 (P , 0.001) and T score was À6.58 6 2.87 (P , 0.001). The average bone volume (BV) was 115.27 6 40.45 mm 3 , trabecular number (Tb.N) was 1.45 6 0.32 (1.009-2.37) and trabecular thickness (Tb.Th) was 0.181 6 0.03 mm (0.111-0.268). The mean bone mineral density measured was 206.24 6 50.58 mg HA/ccm. This study shows that there is highly significant difference between BMD measured by DXA and pQCT, and that bone morphometric analysis indicates that there is marked decrease in the mechanical properties of the bone in the proximal tibia due to knee Osteoarthritis and Osteoporosis indicating poor bone architecture and quality.

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The relation between osteoporosis of the spine and osteoarthritis of the knee

Cited by 12 publications

References 6 publications

The influence of osteoporosis on varus osteoarthritis of the knee

The influence of osteoporosis on varus osteoarthritis of the knee

Interrelationship between bone aging traits and basic anthropometric characteristics

High-Resolution Peripheral Quantitative Computed Tomography (HR-PQCT) and Dual Energy X-Ray Absorptiometry (DXA) Measurements of Proximal Tibia in Patients Undergoing Total Knee Arthroplasty

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