The Relation between Periodontitis and Anemia Asso‌ciated Parameters

Abstract

Introduction: Periodontal disease, an inflammatory and infectious disease in adults and anemia associated with chronic infection, is one of the most common types of anemia. Considering the similarity of pathogens causing periodontal disease and anemia, this study aims to investigate the correlation between hematologic parameters associated with anemia and moderate chronic periodontitis. Materials and Methods:This case-control study was systematically performed on blood samples of 60 healthy men. The control group consisted of 30 men who had healthy periodon um and the case group included 30 men with moderate chronic periodontitis. Clinical examination of patients was done using Williams periodontal probe and assessment of CAL, PPD, BOP and GI. Blood samples were collected at the Department of Periodontology, Babol school of Dentistry and evaluation of red Erythrocyte indices, Hemoglobin, Hematocrit, SI and TIBC was done. Data collected from clinical examinations and laboratory tests were analyzed by T-test, Pearson correlation coefficient and Spearman tests. Results: Reduction of MCV, MCH, Hb, HCT, SI and TIBC factors were observed with increasing GI and CAL and BOP. There is no significant correlation between GI and CAL and BOP and MCHC factor. No Significant correlation exists between PPD changes and hematological factors associated with anemia. Conclusion: A correlation was observed between some hematological parameters associated with anemia and moderate chronic periodontitis.

Comparative Evaluation of Blood Parameters in Chronic Periodontitis Patients and Healthy Patients for Signs of Anemia

“…[15] In the present study, MCV, MCH, MCHC showed no significant co-relation with the periodontitis patients, when compared to individuals with clinically healthy gingiva. Similar results were shown in the studies conducted by Gokhale et al [10] , Malhotra et al [13] , Jenabian et al [19] , and Nair et al [17] Within the limitations of the present study, it can be stated that chronic periodontal diseases are associated with alterations in the hematological parameters which is hemoglobin, erythrocyte sedimentation rate and red blood cells. These findings may be related to the elevated levels of pro-inflammatory cytokines in plasma of periodontitis patients suppressing erythropoiesis.…”

“…This can be attributed to the significantly lower number of RBC's. Similar results were shown in studies conducted by Gokhale et al [10] ,Malhotra et al [13] , Virdi et al [15] , Nair et al [17] , Anand et al [14] and Jenabian et al [19] . On the contrary, no significant co-relation was found in between Hbconcentration and periodontitis cases in a study conducted by Aljohani et al [20] In the present study hematocrit showed a highly significant (P<0.001, t=6.15) relationship in patients with periodontitis, when compared to individuals with clinically healthy gingiva.…”

“…Therefore, the lower value of hematocrit can attributed to the significantly lower number of RBC's . [10] Similar results were shown in studies conducted by Gokhale et al [10] , Malhotra et al [13] ,Jenabian et al [19] ,Anand et al [14] , and Nair et al [17] .…”

Haematological Alteration among Patients with Oral and Dental Health Problems in the Tripoli Region

“…The results of the present study showed a significant (P<0.01) decrease in RBCs count, hemoglobin concentration, hematocrit value, MCV, MCH, and MCHC in patients with oral and dental health problems compared with the control group. These results run parallel with the study of Jenabian et al, [18] who found that a reduction of MCV, MCH, Hb, and Hct in patients with a moderate chronic periodontitis. Several previous studies showed that a significant decrease in Hb and RBCs counts in periodontitis patients when compared to healthy controls [17,[19][20][21][22][23][24][25][26].…”

“…Previously chronic inflammation or infection may be interpreting the underlying cause of anemia of chronic disease (ACD), and increase some of inflammatory cytokines such as TNF-α, IL-1 are observed in ACD. These cytokines lead to decrease the life span of RBC and impair erythroids development and reduce erythropoietin response to anemia and abnormality of iron store, in addition the increase production of inflammatory cytokines inhabit the maturation and differentiation of erythrocytes [13,[33][34][35][36][37] because the cytokines prevent release the erythropoietin from kidney [13,18].…”