The relation between the sensitization to molecular components of inhalant allergens and food reactions in patients suffering from atopic dermatitis

Čelakovská, Jarmila; Bukač, Josef; Vaňková, R.; Krejsek, Jan; Andrýs, Ctirad

doi:10.1080/09540105.2020.1865281

Cited by 8 publications

(3 citation statements)

References 62 publications

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“…Study of IgE specificity revealed an association of sensitization to molecular components of pollen allergens with food reactions in patients suffering from atopic dermatitis. In patients suffering from reactions to peanuts, hazelnuts, celery, apple and peach, a significantly higher frequency of sensitization to major pollen allergens Bet v 1, Aln g 1, Phl p 1, 2, 4, 5, 6, 11 was found ( Čelakovská et al, 2021a ; Čelakovská et al, 2021b ). Interestingly, sensitization to Bet v 1 homologues and profilins is associated with mild symptoms (pollen eating syndrome), and sensitization to LTP homologues and seed storage proteins are associated with severe reactions ( Čelakovská et al, 2021a ).…”

Section: Sensitization To Pollen Allergensmentioning

confidence: 99%

How Do Pollen Allergens Sensitize?

Guryanova

Finkina

Melnikova

et al. 2022

Front. Mol. Biosci.

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Plant pollen is one of the main sources of allergens causing allergic diseases such as allergic rhinitis and asthma. Several allergens in plant pollen are panallergens which are also present in other allergen sources. As a result, sensitized individuals may also experience food allergies. The mechanism of sensitization and development of allergic inflammation is a consequence of the interaction of allergens with a large number of molecular factors that often are acting in a complex with other compounds, for example low-molecular-mass ligands, which contribute to the induction a type 2-driven response of immune system. In this review, special attention is paid not only to properties of allergens but also to an important role of their interaction with lipids and other hydrophobic molecules in pollen sensitization. The reactions of epithelial cells lining the nasal and bronchial mucosa and of other immunocompetent cells will also be considered, in particular the mechanisms of the activation of B and T lymphocytes and the formation of allergen-specific antibody responses.

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Section: Sensitization To Pollen Allergensmentioning

confidence: 99%

How Do Pollen Allergens Sensitize?

Guryanova

Finkina

Melnikova

et al. 2022

Front. Mol. Biosci.

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“…Side effects that may occur with this type of immunization are erythema, pruritus, eczema, and atopic dermatitis at the site of allergen application. EPIT has modest results in terms of inducing food tolerance (28-50%) [62][63][64]. As in the case of SLIT, the main limitation of the method is the amount of allergen that can be administered.…”

Section: Epicutaneous Immunotherapy (Epit)mentioning

confidence: 99%

Food Allergy a Constant Concern to the Medical World and Healthcare Providers: Practical Aspects

Sur

Armat

Duca

et al. 2021

Life

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Food allergy (FA) is a condition with a growing incidence and is a constant concern for the medical world and healthcare providers. With potential symptoms including anaphylaxis, in the event of an allergic reaction the patient’s life may well be endangered. The diagnosis of FA is a continuous challenge because mild cases tend to be ignored or diagnosed late and young children with allergies are cared for by parents, who are not always able to accurately interpret symptoms. It is very important to be able to differentiate FAs from food intolerance and toxic reactions to food. An accurate diagnosis is required to provide personalized management of an FA. More sophisticated and accurate diagnostic tests, including component diagnosis and epitope reactivity, allow the provision of a directed diagnosis, a more accurate therapeutic approach, and a useful prognostic evaluation. Tests used in current practice include the specific search for serum IgE, elimination diets, oral food challenges, single, blind, and double-blind (DBPCFC) tests, as well as skin tests. The risk of anaphylaxis can be assessed by molecular diagnostics/component-resolved diagnosis (CRD) and by conducting a basophilic activation test (BAT). These tests allow a planned, personalized treatment based on molecular and clinical profiles. CRD can determine the individual profile of allergic molecular reactivity and enable the formulation of a prognostic judgment. Our article highlights the importance of knowing the immune mechanisms, diagnostics, and immunotherapies in FAs. Starting from observing exposure to food allergens, to identifying allergic reactions, analysing the severity of clinical manifestations, noting the possibilities of diagnosis, and illustrating adequate management strategies.

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“…It was shown that specific IgE-blocking IgG developed during sublingual immunotherapy (SLIT) with the recombinant Bet v 1 (rBet v 1-SLIT) were cross-reactive with Aln g 1; however, they were unable to fully prevent Aln g 1-induced effector cell activation in the case of the majority of patients [7]. In addition, it is worth noting that plant panallergens of other classes, in particular, profilins and polcalcins, may be involved in sensitization and be responsible for the low effectiveness of AIT in some patients [8].…”

Section: Introductionmentioning

confidence: 99%

Structural and Immunological Features of PR-10 Allergens: Focusing on the Major Alder Pollen Allergen Aln g 1

Melnikova,

Finkina,

Potapov

et al. 2024

IJMS

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Today, allergies have become a serious problem. PR-10 proteins are clinically relevant allergens that have the ability to bind hydrophobic ligands, which can significantly increase their allergenicity potential. It has been recently shown that not only the birch pollen allergen Bet v 1 but also the alder pollen allergen Aln g 1, might act as a true sensitizer of the immune system. The current investigation is aimed at the further study of the allergenic and structural features of Aln g 1. By using qPCR, we showed that Aln g 1 was able to upregulate alarmins in epithelial cells, playing an important role in sensitization. With the use of CD-spectroscopy and ELISA assays with the sera of allergic patients, we demonstrated that Aln g 1 did not completely restore its structure after thermal denaturation, which led to a decrease in its IgE-binding capacity. Using site-directed mutagenesis, we revealed that the replacement of two residues (Asp27 and Leu30) in the structure of Aln g 1 led to a decrease in its ability to bind to both IgE from sera of allergic patients and lipid ligands. The obtained data open a prospect for the development of hypoallergenic variants of the major alder allergen Aln g 1 for allergen-specific immunotherapy.

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The relation between the sensitization to molecular components of inhalant allergens and food reactions in patients suffering from atopic dermatitis

Cited by 8 publications

References 62 publications

How Do Pollen Allergens Sensitize?

How Do Pollen Allergens Sensitize?

Food Allergy a Constant Concern to the Medical World and Healthcare Providers: Practical Aspects

Structural and Immunological Features of PR-10 Allergens: Focusing on the Major Alder Pollen Allergen Aln g 1

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