The relation of depression to in-hospital outcomes among adults hospitalized for firearm-related injury

Kalesan, Bindu; Galea, Sandro

doi:10.1016/j.jad.2015.05.010

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…The relationship between depressive symptoms and other patient and injury characteristics is, at best, weak and inconsistent, so action should be taken to further explore the relationship between symptoms of depression after trauma and psychological or injury-specific characteristics, as well as to propose early measures to prevent depression among trauma patients. For now, clinicians can anticipate symptoms of depression among all trauma patients given the evidence that both minor and major trauma have a notable risk of developing symptoms of depression, which may also lead to worse physical outcomes [3,7,[9][10][11]57].…”

Section: Discussionmentioning

confidence: 99%

“…Greater symptoms of depression are associated with greater symptom intensity and greater magnitude of incapability after musculoskeletal injury and surgery [3,7,[9][10][11]. Greater symptoms of depression are also associated with adverse events, more limited participation in rehabilitation activities, and delayed return to important life roles such as work [3,7,9,10,12].…”

Section: Introductionmentioning

confidence: 99%

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Systematic Review of the Association Between Trauma Severity and Postinjury Symptoms of Depression

et al. 2022

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Background Greater symptoms of depression are associated with greater symptom intensity during recovery from musculoskeletal injury. It is not clear that more severe trauma is associated with greater symptoms of depression as one might expect. The goal of this study was to systematically review the existing evidence regarding the association of Injury Severity Score (ISS) with symptoms of depression during recovery from musculoskeletal injury. Methods Two independent reviewers used PubMed and Embase to identify studies that measured both ISS and symptoms of depression. Among the 17 studies satisfying inclusion criteria, 5 studies assessed the correlation of symptoms of depression and ISS on their continuum; 3 studies compared the mean of symptoms of depression for people above and below a specific ISS level; five compared mean ISS above and below a threshold level of symptoms of depression; and four compared dichotomized ISS and dichotomized depression. Four of the 17 evaluated factors associated with symptoms of depression in multivariable analysis. Results In bivariate analysis, 12 of 17 studies (71%) found no association between ISS level and symptoms of depression. Three studies found a bivariate association that did not persist in multivariable analysis. Two studies reported slight associations in bivariate analysis, but did not perform multivariable analysis. Conclusions The knowledge that symptoms of depression are common during recovery, in combination with the finding of this review that they have little or no relationship with injury severity, directs clinicians to anticipate and address mental health during recovery from physical trauma of any severity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systematic Review of the Association Between Trauma Severity and Postinjury Symptoms of Depression

et al. 2022

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“…PDS is related to the severity of conditions in patients with brain tumors, such as the size, pathologic type, location, and mental state [ 7 ]. However, based on previous studies, depression symptoms before surgery suppress immune function and affect stress level and thyroid hormone levels [ 8 ], which consequently increase the incidence of perioperative cardiac events [ 9 , 10 ], costs [ 11 ], and even suicide attempts during a hospital stay. Additionally, PDS increases the incidence of postoperative delirium, which leads to poor clinical outcomes [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of low-dose ketamine on PerioperAtive depreSsive Symptoms in patients undergoing Intracranial tumOr resectioN (PASSION): study protocol for a randomized controlled trial

Zhou

Peng

Fang

et al. 2018

Trials

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BackgroundPerioperative depressive symptoms (PDS) are common mental comorbidities that influence clinical outcomes and prognosis. However, there is no rapid-acting treatment to address these symptoms during a limited hospital stay.Methods/designThis is a single-center, randomized, placebo-controlled, and double-blind trial. Randomization will be applied and stratified by the severity of PDS (moderate versus severe). Eighty patients who are scheduled for elective supratentorial brain tumor resection with PDS will be randomly allocated to the ketamine or placebo group with a ratio of 1 to 1. Patients in the ketamine group will be administered low-dose ketamine (0.5 mg/kg) intravenously for 40 min while the dural mater is being cut into, whereas patients in the placebo group will receive the same volume of normal saline at the same infusion rate at the same time points. The primary endpoint is the rate of PDS response at 3 days after surgery. Secondary outcomes include efficacy parameters such as the rate of PDS remission and safety outcomes such as the incidence of postoperative delirium, quality of recovery, and psychiatric side effects.DiscussionThis study aims to determine whether ketamine could improve the depressive symptoms of perioperative patients undergoing supratentorial brain tumor resection. It will also examine the safety of administering ketamine as an intraoperative anti-depressant.Trial registrationClinicalTrials.gov, NCT03086148. Registered on 22 March 2017.Electronic supplementary materialThe online version of this article (10.1186/s13063-018-2831-0) contains supplementary material, which is available to authorized users.

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The relation of depression to in-hospital outcomes among adults hospitalized for firearm-related injury

Cited by 2 publications

References 23 publications

Systematic Review of the Association Between Trauma Severity and Postinjury Symptoms of Depression

Systematic Review of the Association Between Trauma Severity and Postinjury Symptoms of Depression

Effect of low-dose ketamine on PerioperAtive depreSsive Symptoms in patients undergoing Intracranial tumOr resectioN (PASSION): study protocol for a randomized controlled trial

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