The Relation of Dietary Nitrogen Consumption to the Rate of Uric Acid Synthesis in Normal and Gouty Man 1

Bień, E; Yu, Tzy‐Chyi; Benedict, Jean D.; Gutman, Alexander B.; Stetten, DeWitt

doi:10.1172/jci102792

Cited by 53 publications

(8 citation statements)

References 1 publication

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“…The effect of protein intake on the synthesis of uric acid has been studied by Bien el al. [3], They showed that a 50% rise in protein intake from a basal level of 13 cal% increased endogenous uric acid by about 50 mg/day or less than 15%. It would appear that dietary proteins have little influence on uric acid formation.…”

Section: Influence O F Diet On Uric Acid Metabolismmentioning

confidence: 99%

Origin and Extrarenal Elimination of Uric Acid in Man

Sørensen¹,

Levinson²

1975

Nephron

126

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The origin of uric acid, metabolic pathways of purine metabolism and the disposition of uric acid in normal man are reviewed. Two thirds of the uric acid is normally excreted through the kidney while one third gains entrance to the gut where it undergoes uricolysis. The pathogenesis of hyperuricemia in primary and secondary gout is discussed. Increased production or decreased excretion of uric acid are the two principal mechanisms of hyperuricemia. The known biochemical defects associated with primary overproduction gout are outlined. Extrarenal uricolysis assumes a greater role when the renal excretion of uric acid is compromised.

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Section: Influence O F Diet On Uric Acid Metabolismmentioning

confidence: 99%

Origin and Extrarenal Elimination of Uric Acid in Man

Sørensen¹,

Levinson²

1975

Nephron

126

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“…10 5 Erosions of oral mucosa on day 3 of higher dose 20 3 Asymptomatic duodenal ulcer demonstrated by X-ray (Films taken at another hospital 2 months previously showed a deformed duodenum) F. J. 5 5…”

Section: Resultsmentioning

confidence: 99%

“…The present day treatment of tophaceous gout consists primarily in the administration of uricosuric agents to increase the renal excretion of the uric acid formed, with use of colchicine, ACTH gel, or phenylbutazone for management of the acute attacks. Control of the production of uric acid has been of necessity confined to limiting the purine and protein content of the diet (5).…”

mentioning

confidence: 99%

Suppression of Uric Acid Synthesis in the Gouty Human by the Use of 6-Diazo-5-Oxo-L-Norleucine*

Grayzel¹,

Seegmiller²,

Love³

1960

J. Clin. Invest.

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“…High intakes of casein in rats have been reported to cause a rapid increase in liver RNA content [17] and in de novo purine synthesis without any change of the total adenine and guanine nucleotide pools in liver [17,18]. Similarly, intakes of high dietary protein by humans resulted in increased urinary excretion of uric acid (hyperuricosuria) [19][20][21], due to an accelerated turnover rate of the uric acid pool [20].…”

Section: Discussionmentioning

confidence: 99%

Uricogenic potential of selected cooked foods in rats.

Brulé

Sarwar

Savoie

1990

Journal of the American College of Nutrition

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Samples of beefsteak, beef liver, haddock, and mushrooms were cooked by two methods: boiling and broiling. Growth and purine metabolism in rats fed diets containing 20% protein (N x 6.25) were studied for a period of 26 days. The cooked meats and fish were used as the sole source of dietary protein, while cooked mushrooms provided 5% protein in mushroom-casein diets. Body weight, and food and water intakes were recorded weekly while total urine was collected during the last 6 days of the feeding period. Levels of purine metabolites (uric acid and allantoin) in blood and urine were determined by enzymatic methods and reverse-phase HPLC techniques. Dietary treatments had no significant effects on weight gain and food consumption. Compared with animals fed the casein control diet, rats fed the broiled liver, broiled haddock, and boiled mushroom diets had significantly (p less than 0.05) higher concentrations of serum allantoin, suggesting that uricogenicity of these foods was influenced by the method of cooking. The renal excretion of purine metabolites was significantly correlated with purine intake, the renal excretion of allantoin and uric acid being the highest in rats fed the liver diets.

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The Relation of Dietary Nitrogen Consumption to the Rate of Uric Acid Synthesis in Normal and Gouty Man 1

Cited by 53 publications

References 1 publication

Origin and Extrarenal Elimination of Uric Acid in Man

Origin and Extrarenal Elimination of Uric Acid in Man

Suppression of Uric Acid Synthesis in the Gouty Human by the Use of 6-Diazo-5-Oxo-L-Norleucine*

Uricogenic potential of selected cooked foods in rats.

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