The Relation of Food to Infantile Eczema

O'Keefe, Edward S.

doi:10.1056/nejm192011111832003

Cited by 31 publications

(7 citation statements)

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“…The presence of food allergens in breast milk was described early this century [85][86][87] and includes the classic studies of Donnally [88] who used breast milk from mothers who had eaten egg to show skin-test positivity in patients who were allergic to: egg. Subsequent studies confirmed these findings [76,81,82,[89][90][91][92][93][94].…”

Section: Sensitizationmentioning

confidence: 99%

Peanut allergy

Loza

Brostoff

1995

Clin Experimental Allergy

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Section: Sensitizationmentioning

confidence: 99%

Peanut allergy

Loza

Brostoff

1995

Clin Experimental Allergy

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“…It has been recognized for about 70 years that breast-fed infants may react to food proteins which have passed from mother to infant via the breast milk [1,2]. Recent studies have reported the presence of one of the major cows' milk allergens [3] belonging to the whey protein fraction, ^-lactoglobulin (BLG), in human milk as analysed by immunological methods [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Bovine β‐1actoglobulin in human milk from atopic and non‐atopic mothers. Relationship to maternal intake of homogenized and unhomogenized milk

Høst

Husby

Hansen

et al. 1990

Clin Experimental Allergy

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Human milk samples (n = 300) were collected during a 3-week period from 10 healthy mothers and from 10 atopic mothers, all with healthy, solely breast-fed infants. The milk samples were analysed by an enzyme-linked immunosorbent assay (ELISA) for the content of bovine beta-lactoglobulin (BLG). In a cross-over design the atopic and non-atopic mothers alternated their intake of milk between homogenized and unhomogenized milk each week. On day 7, in each week, consecutive milk samples were taken before and 4, 8, 12 and 24 hr after a single ingestion of 500 ml of homogenized or unhomogenized milk. Detectable amounts of BLG (0.9-150 micrograms/l, median value 4.2 micrograms/l) were measured in 19/20 of the mothers (95%), in 9 of 10 atopic mothers and in all 10 of 10 non-atopic mothers. No correlation was found between the type of milk preparation (homogenized or unhomogenized) and the presence of BLG or the level of BLG in human milk. A great intra-individual and inter-individual variation of BLG level was found, and no relationship was observed between BLG levels and atopic status of the mothers. The interval between ingestion of 500 ml of milk and the maximal concentration of BLG on milk-free diet varied between 4 and 24 hr, median value 8 hr. The presence of BLG in human milk is a common finding in both atopic and non-atopic mothers.

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“…It has been recognized for about 60 years that breast-fed infants may react to foods, e.g. chocolate (l), cow's milk, egg, fish, and oats (2), the components of which have passed from mother to infant via the breast-milk (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The reported symptoms have mainly been eczema, exanthema, diarrhoea, vomiting and infantile colic.…”

mentioning

confidence: 99%

A Prospective Study of Cow's Milk Allergy in Exclusively Breast‐Fed Infants

Husby²,

1988

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A cohort of 1,749 newborns in the municipality of Odense were followed prospectively for the development of cow's milk allergy (CMA) during their first year of life. Altogether 39 fulfilled the criteria for CMA (2.2%). Out of the 39 infants, 17 developed symptoms of CMA during breast-feeding, in all cases before the age of 3 months. Nine of these were solely breast-fed at the time of diagnosis, giving a one year incidence of CMA in exclusively breast-fed infants of 0.5% (9/1,749) in a study population with a frequency of exclusive breast-feeding of 52% at 3 months of age. None of the infants had signs of CMA in the neonatal period. Review of records from the newborn nursery revealed that all 9 infants had been exposed to cow's milk formula in amounts corresponding to approximately 0.4-3.0 g of beta-lactoglobulin (BLG) during the first three days of life. Human milk samples were analyzed by enzyme-linked immunosorbent assay (ELISA) for the content of bovine BLG. Detectable amounts (0.5-45 ng/ml) were found in 3/9 samples of human milk against which the infants reacted clinically. Analysis of the size distribution by high pressure liquid gel permeation chromatography in combination with ELISA indicated a molecular weight of BLG corresponding to that of monomeric BLG (18 kD). Possibly early inadvertent and occasional exposure to cow's milk proteins may initiate sensitization in predisposed neonates. Subsequent exposure to minute amounts of bovine milk proteins in human milk may act as booster doses eliciting allergic reactions.

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The Relation of Food to Infantile Eczema

Cited by 31 publications

References 0 publications

Peanut allergy

Peanut allergy

Bovine β‐1actoglobulin in human milk from atopic and non‐atopic mothers. Relationship to maternal intake of homogenized and unhomogenized milk

A Prospective Study of Cow's Milk Allergy in Exclusively Breast‐Fed Infants

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