The relation of innate and adaptive immunity with viral-induced acute asthma attacks: Focusing on IP-10 and cathelicidin

Arıkoğlu, Tuğba; Akyilmaz, E.; Yıldırım, Didem Derici; Batmaz, Sehra Birgül; Ülger, Süleyman; Aslan, Gönül; Kuyucu, Semanur

doi:10.1016/j.aller.2016.07.003

Cited by 9 publications

(10 citation statements)

References 46 publications

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“…Abundant data support the hypothesis that CXCL10 functions as a biomarker for severe asthma and virus-, especially rhinovirus-, induced asthma [21][22][23]. The level of CXCL10 is reported to be higher in asthmatic sputum than in healthy subjects [24], and higher in acute asthmatics' serum compared to serum from controlled asthmatics [25]. In vitro, addition of Th2 cytokines to virus-infected cells elevated release of CXCL10 [26], and CXCL10 itself induced adhesion of eosinophils to ICAM-1 and release of EDN from eosinophils [27].…”

Section: Discussionmentioning

confidence: 93%

Baseline serum CXCL10 and IL-12 levels may predict severe asthmatics' responsiveness to omalizumab

Suzukawa

Matsumoto

Ohshima

et al. 2018

Respiratory Medicine

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Section: Discussionmentioning

confidence: 93%

Baseline serum CXCL10 and IL-12 levels may predict severe asthmatics' responsiveness to omalizumab

Suzukawa

Matsumoto

Ohshima

et al. 2018

Respiratory Medicine

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“…According to Huang et al [ 53 ] and Xiao et al [ 57 ], cathelicidin concentration in sputum may be a biomarker separating COPD from asthma. Furthermore, two studies (20%) by Arikoglu et al (2015) and Arikoglu et al (2017) found lower LL-37 levels in stable asthma versus asthma exacerbations [ 59 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…Greiller et al (2019) conducted experiments as part of their vitro study to evaluate the effect of vitamin D on responses of respiratory epithelial cells to infection with rhinoviruses, a common respiratory tract pathogen [ 59 ]. Greiller et al (2019) linked vitamin D effects to increased expression of cathelicidin [ 59 ]. However, the clinical study conducted by Arikoglu et al (2015) only partially validated the conclusion of Greiller at al.…”

Section: Resultsmentioning

confidence: 99%

A Scoping Analysis of Cathelicidin in Response to Organic Dust Exposure and Related Chronic Lung Illnesses

Golec

Lemieszek

Dutkiewicz

et al. 2022

IJMS

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Over two billion people worldwide are exposed to organic dust, which can cause respiratory disorders. The discovery of the cathelicidin peptide provides novel insights into the lung’s response to organic dust; however, its role in the lung’s response to organic dust exposure and chronic lung diseases remains limited. We conducted a scoping review to map the current evidence on the role of cathelicidin LL-37/CRAMP in response to organic dust exposure and related chronic lung diseases: hypersensitivity pneumonitis (HP), chronic obstructive pulmonary disease (COPD) and asthma. We included a total of n = 53 peer-reviewed articles in this review, following the process of (i) a preliminary screening; (ii) a systematic MEDLINE/PubMed database search; (iii) title, abstract and full-text screening; (iv) data extraction and charting. Cathelicidin levels were shown to be altered in all clinical settings investigated; its pleiotropic function was confirmed. It was found that cathelicidin contributes to maintaining homeostasis and participates in lung injury response and repair, in addition to exerting a positive effect against microbial load and infections. In addition, LL-37 was found to sustain continuous inflammation, increase mucus formation and inhibit microorganisms and corticosteroids. In addition, studies investigated cathelicidin as a treatment modality, such as cathelicidin inhalation in experimental HP, which had positive effects. However, the primary focus of the included articles was on LL-37’s antibacterial effect, leading to the conclusion that the beneficial LL-37 activity has not been adequately examined and that further research is required.

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“…CXCL10 secreted by epithelial cells may participate in airway in ammation and AHR through activation and recruitment of immune cells. CXCL10 can interact with CXCR3, which is expressed on activated CD4 + , CD8 + and NKT cells, mast cells and eosinophils, and stimulates the migration of these cells [30].The presence of mast cells in the airways is characteristic of asthma. Viral infection may lead to the release of CXCL10 in the bronchial epithelium, which activates mast cells and allows them to migrate to airway smooth muscles to exacerbate airway in ammation and bronchoconstriction in asthma [31].…”

Section: Discussionmentioning

confidence: 99%

Respiratory Syncytial Virus Infection Induces Airway Hyperresponsiveness Through miR-34b/c-5p/CXCL10 Axis

Liú¹,

Tang²,

Bajinka³

et al. 2021

Preprint

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Background: There is growing evidence on miRNAs with pivotal role in viral infection-induced airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). However, the related mechanism of RSV infection affecting airway inflammation and airway hyperresponsiveness (AHR) is largely unknown.Methods：We obtained the miRNA and mRNA databases of patients with RSV infection, as well as the miRNA databases of asthma and COPD patients from the GEO database. Through intergrated analysis we screened differentially expressed miRNAs (DEmiRs) and genes (DEGs).Further analysis was carried out to obtain the hub gene through the biological pathways and enrichment pathways of DEGs targeted by DEmiRs and construction of a protein-protein interaction (PPI) network. Finally, the expression of DEmiRs and hub gene were verified in vivo and in vitro experiments, and the regulatory relationship between DEmiRs and hub gene was further explored.Results: The five differential molecules (miR-34b/c-5p, CD14, CXCL10 and RHOH) screened through animal experiments have the same expression trend in the acute and chronic phases of RSV infection. Following the infecting of BEAS-2B cells with RSV, we confirmed that RSV infection can down-regulate miR-34b/c-5p, and the expression levels of CXCL10 and CD14 were significantly increased in the infected group. Furthermore, the results of the dual-luciferase reporter assay showed that CXCL10 is the target of miR-34c-5p.Conclusion: We confirmed that the increase of CXCL10 after RSV infection is regulated by miR-34b/c-5p. This study shed some lights on the mechanism of RSV infection affecting airway inflammation and AHR. In addition, the study provides diagnostic indicators and therapeutic targets for AHR caused by persistent RSV infection.

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The relation of innate and adaptive immunity with viral-induced acute asthma attacks: Focusing on IP-10 and cathelicidin

Abstract: Innate immunity biomarkers such as serum IP-10 and cathelicidin can be used to predict viral-induced acute asthma. These biomarkers may provide potential new treatment targets for acute asthma.

Cited by 9 publications

References 46 publications

Baseline serum CXCL10 and IL-12 levels may predict severe asthmatics' responsiveness to omalizumab

Baseline serum CXCL10 and IL-12 levels may predict severe asthmatics' responsiveness to omalizumab

A Scoping Analysis of Cathelicidin in Response to Organic Dust Exposure and Related Chronic Lung Illnesses

Respiratory Syncytial Virus Infection Induces Airway Hyperresponsiveness Through miR-34b/c-5p/CXCL10 Axis

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