We write this chapter at a time when individuals, organizations, nations, and our world are faced with monumental challenges. Economies around the world are in the throes of a global recession: financial and employment markets are the worst since the Great Depression. Our planet is under assault from human activities, and its resources to sustain life are being irreversibly taxed. Resources that have traditionally fueled economic development are being depleted with reverberating economic and geopolitical repercussions. Against these calamities, humanity is being exalted to new heights through scientific and technological advances, but especially through increased communication and data storage, management, and utilization capabilities. Many of these advances, unprecedented in their reach, have rendered our world a truly global village. Organizations and employees of today must adapt and function against this backdrop. Challenges of environmental and economic sustainability, transformational forces of technological and demographic change, and concomitant globalization of markets and the workplace, are already having a dramatic impact on research and practice of personnel selection. For the science of personnel selection to retain its relevance to organizational and societal needs, the monumental changes of our times need to be incorporated into our models.