The Relation of Langerhans Cell Histiocytosis to Acute Leukemia, Lymphomas, and Other Solid Tumors

Pulmonary Langerhans Cell Histiocytosis Associated with Lingual Carcinoma

“…In this case, it is possible that the LCH that developed only in the lung could have been induced by the cytokines released from the lingual carcinoma cells and habitual smoking. Egeler et al have suggested that treatment of an underlying malignant tumor should first be considered for control of LCH since LCH is a reactive process to tumors and may be induced by the release of cytokines from these tumors (10). This suggestion is consistent with the clinical course that was observed in this patient after resection of the lingual carcinoma.…”

Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone

“…[13][14][15][16][17][18] Magni et al described a patient with FL in an inguinal lymph node and synchronous Langerhans cell histiocytosis on the scalp, 19 and reported identical clonal immunoglobulin gene rearrangements in both lesions. Anjuère et al suggested that Langerhans cells may develop from a "lymphoid-committed" precursor, based on evidence in mice that epidermal Langerhans cells can be generated from the same CD4 low precursors that generate B cells, T cells, and natural killer (NK) cells.…”

Langerhans cell histiocytosis in acute leukemias of ambiguous or myeloid lineage in adult patients: support for a possible clonal relationship

“…1 Rarely, LC histiocytosis may be associated with various hematologic neoplasms including acute lymphoblastic and myeloid leukemias, other clonal myeloid neoplasms, and lymphomas. [2][3][4] Acute lymphoblastic leukemia is more often associated with LC histiocytosis in children, whereas lymphoma and acute myeloid leukemia are more common in adults, which may reflect the frequency of these diseases in the respective populations. 2,4 Most cases of acute myeloid leukemia associated with LC histiocytosis appear to be treatment related as they occur years after cytotoxic treatment for LC histiocytosis; however, in some cases, LC histiocytosis occurs concurrently or follows acute myeloid leukemia.…”

“…[2][3][4] Acute lymphoblastic leukemia is more often associated with LC histiocytosis in children, whereas lymphoma and acute myeloid leukemia are more common in adults, which may reflect the frequency of these diseases in the respective populations. 2,4 Most cases of acute myeloid leukemia associated with LC histiocytosis appear to be treatment related as they occur years after cytotoxic treatment for LC histiocytosis; however, in some cases, LC histiocytosis occurs concurrently or follows acute myeloid leukemia. 2,4 The biologic relationship of LC histiocytosis with hematologic neoplasms remains to be fully elucidated.…”

“…2,4 Most cases of acute myeloid leukemia associated with LC histiocytosis appear to be treatment related as they occur years after cytotoxic treatment for LC histiocytosis; however, in some cases, LC histiocytosis occurs concurrently or follows acute myeloid leukemia. 2,4 The biologic relationship of LC histiocytosis with hematologic neoplasms remains to be fully elucidated. In some instances, LC histiocytosis appears to be incidentally associated without evidence of dissemination or progression, 5 whereas in others the LC histiocytosis follows an aggressive course.…”