The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk

Abstract

These findings, if confirmed, may provide a new avenue for the personalized prevention of magnesium deficiency and, thus, colorectal cancer.

Variation in intakes of calcium, phosphorus, magnesium, iron and potassium in 10 countries in the European Prospective Investigation into Cancer and Nutrition study

“…Evidence associating magnesium, potassium and phosphorus intakes with cancer risk is less well established (Folsom and Hong, 2006;Lin et al, 2006;Dai et al, 2007;van den Brandt et al, 2007;Wolf et al, 2007). Higher magnesium intakes have, however, been associated with reductions in systemic inflammation, blood pressure and metabolic syndrome, and hypomagnesemia has been identified in subjects with type II diabetes (Mizushima et al, 1998;Song et al, 2005aSong et al, , b, 2007Barbagallo et al, 2007;Larsson and Wolk, 2007).…”

Effect of Biofield Energy Healing Treatment (The Trivedi Effect<sup>®</sup>) Based Herbomineral Formulation on Pro-Inflammatory Cytokines Expression in Murine Dendritic and Splenocyte Cells

“…Selenium produces antioxidant properties by scavenging free-radicals. Selenium also plays an important role in several immunological and metabolic processes of phagocyted bacteria during intracellular digestion [9]. Many trace elements such as zinc, magnesium, selenium, copper and manganese etc.…”

Magnesium in the Central Nervous System

“…Intriguingly, the association between low intake of Mg and colon cancer seems to be due, at least in part, to the increased formation of N--nitroso compounds, most of which are potent carcinogens (Chiu et al, 2010). That Mg has a role in colon neoplasia is supported by the association of adenomatous and hyperplastic polyps with a genetic polymorphism of Transient Receptor Potential Melastatin (TRPM)--7 (Dai et al, 2007), a ubiquitous ion channel with a central role in Mg uptake and homeostasis . Indeed, the subjects carrying the Thr1482--Ile variant allele are at high risk of Mg deficiency and, in turn, of colorectal neoplasia (Dai et al, 2007).…”

“…That Mg has a role in colon neoplasia is supported by the association of adenomatous and hyperplastic polyps with a genetic polymorphism of Transient Receptor Potential Melastatin (TRPM)--7 (Dai et al, 2007), a ubiquitous ion channel with a central role in Mg uptake and homeostasis . Indeed, the subjects carrying the Thr1482--Ile variant allele are at high risk of Mg deficiency and, in turn, of colorectal neoplasia (Dai et al, 2007). While total Mg consumption has been linked to a significant lower risk of colorectal adenoma and hyperplastic polyps (Dai et al, 2007), unequivocal evidence that Mg reduces the risk of cancer will only be obtained by demonstrating that Mg supplementation prevents colorectal cancer.…”

“…Indeed, the subjects carrying the Thr1482--Ile variant allele are at high risk of Mg deficiency and, in turn, of colorectal neoplasia (Dai et al, 2007). While total Mg consumption has been linked to a significant lower risk of colorectal adenoma and hyperplastic polyps (Dai et al, 2007), unequivocal evidence that Mg reduces the risk of cancer will only be obtained by demonstrating that Mg supplementation prevents colorectal cancer. The role of Mg in lung cancer is rather controversial.…”