The relation of maternal hypothyroidism and hypothyroxinemia during pregnancy on preterm birth: An updated systematic review and meta-analysis

Nasirkandy, Marzieh Parizad; Badfar, Gholamreza; Shohani, Masoumeh; Rahmati, Shoboo; YektaKooshali, Mohammad Hossein; Abbasalizadeh, Shamsi; Soleymani, Ali; Azami, Milad

doi:10.29252/ijrm.15.9.543

Cited by 29 publications

(26 citation statements)

References 49 publications

(36 reference statements)

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“…Among the 52 included eligible MAs, 4628–73 (46/52, 88.5%) were published in English, and the rest74–79 (6/52, 11.5%) were published in Chinese. The 52 included MAs contained 685 studies, with an average of 13.2 (range: 3–39) studies per article.…”

Section: Resultsmentioning

confidence: 99%

“…Ten39 40 43 49 57 58 65 68–70 MAs were about the associations between OH and other diseases, and 3528–36 38 42 44–47 50–56 59–64 66 67 75–79 MAs have shown the associations between SCH and other diseases. Seven37 41 48 71–74MAs have investigated the effects of both OH and SCH on other diseases. Except for the general population, pregnant women with hypothyroidism were also included in the target groups of the included MAs 35 37 40 41 48 51 61 64 67 71 74.…”

Section: Resultsmentioning

confidence: 99%

“…Seven37 41 48 71–74MAs have investigated the effects of both OH and SCH on other diseases. Except for the general population, pregnant women with hypothyroidism were also included in the target groups of the included MAs 35 37 40 41 48 51 61 64 67 71 74. The characteristics of these MAs are shown in table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Items 7 and 8 recommend the assessment of the scientific quality of the original articles and consideration of the scientific quality when formulating conclusions, which should be based on scientific and cautious research results to provide an objective and reasonable suggestion for clinical professionals and stakeholders. Nineteen (36.5%)31 33 36 37 39 44 50 53 56 57 59 61 62 70–72 77–79 MAs did not assess the scientific quality of the included studies, which might decrease the credibility of the conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…Six MAs40 41 48 64 71 74 have shown that pregnant women with OH were at high risk for preterm birth. The average number of patients was more than one million, and the average AMSTAR score was 8.8 (range: 8–10).…”

Section: Discussionmentioning

confidence: 99%

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Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis

Tian¹,

Shao²,

Qin³

et al. 2019

BMJ Open

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ObjectivesThere is an increasing prevalence of hypothyroidism and there is a growing body of meta-analyses (MAs) on the association between hypothyroidism and other diseases. However, the methodological quality of the MAs significantly varies. Thus, this study aimed to evaluate and summarise data on the methodological quality of MAs on the associations between hypothyroidism and other diseases using the Assessment of Multiple Systematic Reviews (AMSTAR) scale, providing suggestions for clinical decision-making processes.DesignTo assess the methodological quality of MAs using the AMSTAR scale.Data sourcesA systematic literature search was performed in PubMed, EMBASE, the Cochrane Library, web of science and Chinese Biomedicine Literature Database.Eligibility criteriaWe included MAs that had assessed the association between hypothyroidism and other diseases in humans and that had full texts regardless of the publication status. No restriction applied on language or date.Data extraction and synthesisTwo reviewers independently screened the titles and abstracts of all searched literature to acquire potentially eligible publications. The full texts of possible eligible publications were downloaded and assessed. Inconsistent comments were resolved through discussions with a third reviewer.Results52 studies were included. The average AMSTAR score of the included articles was 8.6 (range: 5–10), and those of English and Chinese MAs were 8.8 and 7.0, respectively. A total of 52 MAs were evaluated, and 19 (36.5%) and 33 (63.5%) of these MAs were of moderate and high quality, respectively. None of the MAs were of low quality. Only two MAs had an a priori design. Items 3, 5 and 9 had the highest compliance (50/52, 96.2%), and aside from item 1, items 7 and 8 had the lowest compliance (33/52,63.5%). According to the results of these MAs, hypothyroidism was significantly associated with cardiovascular diseases, metabolic diseases, neuropsychiatric disorders, breast cancer and pregnancy outcome.ConclusionsThe methodological quality of the included MAs on the association between hypothyroidism and other diseases was moderate to high. MAs with high qualities confirmed that hypothyroidism was significantly associated with cardiovascular diseases, metabolic syndrome, preterm birth and neonatal outcomes. Consideration of scientific quality when formulating conclusions should be made explicit and more attention should be paid to improving the methodological quality of MAs, and increasing their applicability for clinical decision-making.

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Section: Resultsmentioning

confidence: 99%