The Relation of Oedema to Serum Protein and Pseudocholinesterase Levels in the Malnourished Infant

Montgomery, R. D.

doi:10.1136/adc.38.200.343

Cited by 35 publications

(9 citation statements)

References 22 publications

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“…The percentage increase of 11 % in the means from phase 1 to 2, although an underestimate of the rise in intravascular albumin mass in phase 1 in some children, was less than expected in view of the known rapid rise in serum albumin in recovering malnourished children (43). This rise was minimized by the design of the present study, since mainly nonedematous marasmic children were chosen, whose serum albumin levels were not particularly low (44). The three children admitted with mild edema were kept on a high protein diet up to 10 days until free from edema before the study was begun.…”

Section: Discussionmentioning

confidence: 69%

Albumin metabolism: effect of the nutritional state and the dietary protein intake

James¹,

Hay²

1968

J. Clin. Invest.

176

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A B S T R A C T Nine malnourished and nine children who had recovered from malnutrition were given a single injection of albumin-131I and were studied during consecutive periods in which the dietary protein was changed.Malnourished children had significantly lower catabolic rates of albumin than had recovered children on the same protein intake. Both nutritional groups, however, showed a progressive fall in catabolic rate after 3-5 days on a low protein diet (0.7-1.0 g/kg per day), and the maximum effect was seen in the 2nd wk of low protein feeding. The catabolic rate could return to normal within 3 wk in a malnourished child fed 4 g of protein/kg per day.The albumin synthetic rate was measured by a computer technique suitable for nonsteady-state conditions. The synthetic rate in the malnourished groups (101 mg/kg per day) fed on a low protein diet was significantly lower than the rate in the recovered groups (148 mg/kg per day). The synthetic rate responded rapidly to a change in diet; when the rate fell, the intravascular albumin mass was maintained by two compensating mechanisms: (1) a net transfer of extravascular albumin into the intravascular pool; and (2) by a delayed fall in the catabolic rate. The net transfer of albumin into the intravascular compartment diminished as the catabolic rate fell.Adaptation to a low protein diet was associated with: (a) low synthetic and catabolic rates of albumin; (b) a reduced extravascular albumin mass;

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Section: Discussionmentioning

confidence: 69%

Albumin metabolism: effect of the nutritional state and the dietary protein intake

James¹,

Hay²

1968

J. Clin. Invest.

176

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“…In malnourished children with marasmus and edematous undernutrition (or kwashiorkor), serum BChE, total proteins, and albumin levels are lower than those measured in normal children; these values tend to increase after 3 weeks of nutritional rehabilitation [16]. In a similar study on 200 malnourished infants, the degree of edema resulted to be inversely related to BChE and albumin levels; a similar trend of serum BChE values was observed in undernourished adults [17].…”

Section: Protein-energy Malnutrition and Inflammationmentioning

confidence: 71%

Butyrylcholinesterase as a prognostic marker: a review of the literature

Santarpia

Grandone

Contaldo

et al. 2012

J cachexia sarcopenia muscle

230

171

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BackgroundButyrylcholinesterase (BChE) is an α-glycoprotein synthesized in the liver. Its serum level decreases in many clinical conditions such as acute and chronic liver damage, inflammation, injury and infections, and malnutrition.Methods and resultsThis review collects the main evidence on the emerging role of butyrylcholinesterase as a prognostic marker of liver and nonliver diseases as well as a marker of protein-energy malnutrition and obesity. In fact, serum concentrations and BChE activity seem to accurately reflect the availability of amino acidic substrates and/or derangement in protein synthesis due to hepatocellular damage. In cancer, with or without liver impairment, serum BChE levels serve as an accurate functional and prognostic indicator, useful for monitoring clinical and therapeutic interventions according to patients’ prognosis. In the absence of inflammation, BChE could also serve as an index of the effectiveness of nutritional support.ConclusionsSerum BChE assessment should be included in routine clinical diagnostic procedures to evaluate patient clinical conditions, in particular in cases of inflammation and/or protein-energy malnutrition.

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“…Hypoproteinemia and increased microvascular permeability, which is known to be altered in patients with low serum albumin, contributes to the escape of serum pro- teins in the interstitial space and the formation of ascites (30). A study on undernourished infants and adults demonstrated the inverse relationship between degree of edema and BChE and albumin serum concentration (31). It seems likely that chronically low serum proteins -in particular BChE and albumin -are associated with low HRQOL per se but also contribute to the development of cirrhotic ascites.…”

Section: Discussionmentioning

confidence: 99%