The relation of recombination to mutational advance

Müller, Hermann J.

doi:10.1016/0027-5107(64)90047-8

Cited by 2,334 publications

(1,729 citation statements)

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“…The theoretical advantages to outcrossing in facilitating adaptive evolution (Fisher, 1930;Muller, 1932;Hamilton et al, 1990) and in eliminating deleterious mutations (Muller, 1964 ;Felsenstein, 1974 ;Kondrashov, 1988 ;Charlesworth, 1990 ;Gabriel et al, 1993) form enticing hypotheses for male persistence in this species, but other possibilities -namely the notion that malespecific genes and loci that influence X non-disjunction might act as selfish genetic elements -must be excluded before this may be considered definitive. Clearly, dissection of the evolutionary forces responsible for the persistence of males in populations of C. elegans and other androdioecious nematodes remains a topic requiring further inquiry.…”

Section: (I) Experimental Verification Of the Sex Ratio Modelmentioning

confidence: 99%

The proximate determinants of sex ratio in C. elegans populations

2003

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SummaryThe soil nematode Caenorhabditis elegans is an example of a species in which self-fertilizing hermaphrodites predominate, but functional males continue to persist -allowing outcrossing to persevere at low levels. Hermaphrodites can produce male progeny as a consequence of sex chromosome non-disjunction or via outcrossing with males. Consequently, the genetics of sex determination coupled with the efficiency by which males find, inseminate and obtain fertilizations with hermaphrodites will influence the frequency at which males and outcrossing occurs in such populations. Behavioural and physiological traits with a heritable basis, as well as ecological characters, may influence male reproductive success and therefore sex ratio. Because sex ratio is tied to male reproductive success, sex ratio greatly affects outcrossing rates, patterns of genetic variation, and the ability of natural selection to act within populations. In this paper we explore the determinants of male frequency in C. elegans with a mathematical model and experimental data. We address the role of the genetic machinery of sex determination via sex chromosome non-disjunction on sex ratio and the influence of physiological components of C. elegans ' life history that contribute to variation in sex ratio by way of male reproductive success. Finally, we discuss the short-term and long-term factors that are likely to affect sex ratio and breeding system evolution in species like C. elegans.

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Section: (I) Experimental Verification Of the Sex Ratio Modelmentioning

confidence: 99%

The proximate determinants of sex ratio in C. elegans populations

2003

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“…These changes can alter the relative length, gene content and chromatin structure of the sex chromosomes. Hence, suppression of homologous recombination plays a key role in the divergence in shape (heteromorphy) that characterises many sex chromosome pairs [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…This apparent association between the function of sex determination and suppression of recombination has led to the suggestion that restricted recombination in sex chromosomes evolves due to selection to resolve sexually antagonistic genetic interactions [2,[9][10][11]. This sexual antagonism hypothesis has assumed the status of conventional wisdom, to the extent that, in many recent publications, sexual antagonism is the only hypothesis suggested to account for restricted recombination in sex chromosomes [1,6,[12][13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

No amicable divorce? Challenging the notion that sexual antagonism drives sex chromosome evolution

Ironside¹

2010

BioEssays

119

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Ironside, J. E. (2010). No amicable divorce? Challenging the notion that sexual antagonism drives sex chromosome evolution. Bioessays, 32, (8), 718-726. IMPF: 04.47 RONO: 00Although sexual antagonism may have played a role in forming some sex chromosome systems, there appears to be little empirical or theoretical justification in assuming that it is the driving force in all cases of sex chromosome evolution. In many species, sex chromosomes have diverged in size and shape through the accumulation of mutations in regions of suppressed recombination. It is commonly assumed that recombination is suppressed in sex chromosomes due to selection to resolve sexually antagonistic pleiotropy. However, the requirement for a sex chromosome-specific mechanism for suppressing recombination is questionable, since more general models of recombination suppression on autosomes also appear to be applicable to sex chromosomes. Direct tests of the predictions of the sexual antagonism hypothesis offer only limited support in specific sex chromosome systems and circumstantial evidence remains open to interpretation.Peer reviewe

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“…A prolonged advantage of multiple heterozygotes could, in some circumstances, lead to the evolution of coadapted gene complexes (Dobzhansky, 1970). A second possibility is that the chromosomal arrangements (standard and inverted) accumulate deleterious recessive mutations because complementation, and the absence of recombination, prevent their selective elimination from the gene pool (Muller, 1964;Charlesworth, 1978).…”

Section: Introductionmentioning

confidence: 99%

Associations of enzymic and chromosomal polymorphisms in the seaweed fly, Coelopa frigida

et al. 1982

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SUMMARYPopulations of the seaweed fly Coelopa frigida are polymorphic at three loci determining the enzymes peptidase-1 (Pep-i), alcohol dehydrogenase (Adh) and larval esterase-2 (Es-2). Alleles at these loci have been shown by others to be non-randomly associated with each other. In the present paper we report non-random associations between the Adh and Es-2 loci and inversions on chromosome I. The two common alleles Adh-B and D are in strong linkage disequilibrium with the a and /3 inversions, but the Adh-A and C alleles are not so. The X and Y alleles at the Es-2 locus show weak, but still significant, associations with the inversions. We consider possible linkage relationships of the loci on the chromosomal arrangements, and discuss the hypothesis that they constitute part of a coadapted gene complex whose members code for functionally related enzymes.

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The relation of recombination to mutational advance

Cited by 2,334 publications

References 2 publications

The proximate determinants of sex ratio in C. elegans populations

The proximate determinants of sex ratio in C. elegans populations

No amicable divorce? Challenging the notion that sexual antagonism drives sex chromosome evolution

Associations of enzymic and chromosomal polymorphisms in the seaweed fly, Coelopa frigida

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