The Relation of Serotonin-Related Gene and<i>COMT</i>Gene Polymorphisms With Criminal Behavior in Schizophrenic Disorder

Koh, Kyung Bong; Choi, Eun Hee; Lee, Young Joon; Han, Mooyoung; Choi, Sung-Won; Kim, So Won; Lee, Min Goo

doi:10.4088/jcp.10m06443

Cited by 12 publications

(4 citation statements)

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“…Findings of the present study are consistent with some of the results of Lafuente et al, 12 who found no linkage between the À141C Ins/Del polymorphism and the catechol-O-methyltransferase polymorphism (AÀ278 G, G158A), which has been widely studied as a susceptibility gene for the risk of schizophrenia. [22][23][24][25] In view of the relatively small sample analysed in the present study, replicate studies to evaluate these possibilities are in progress.…”

Section: Discussionmentioning

confidence: 97%

Functional −141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter and schizophrenia in a Chinese Han population

et al. 2013

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Section: Discussionmentioning

confidence: 97%

Functional −141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter and schizophrenia in a Chinese Han population

et al. 2013

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“…Numerous studies have shown that low levels of serotonin are associated with both reactive and instrumental aggression [2] , [7] , [8] , [10] , [25] , [31] , [34] , [41] , [43] , [45] , [51] , [66] , [74] – [78] and impulsivity. [7] , [10] , [22] , [25] , [31] , [34] , [37] , [43] , [51] , [72] , [77] , [79] In addition, low serotonin levels [31] , [55] and reduced levels of 5-hydroxyindoleacetic acid, a serotonin metabolite, have been found in aggressive or violent populations. [2] , [31] , [41] , [43] , [52] , [74] Furthermore, a negative correlation between the serotonin 5-HT1A receptor and aggressive behaviour has been established.…”

Section: Resultsmentioning

confidence: 99%

“… [6] , [17] , [41] , [61] , [66] , [75] , [101] – [105] Given the influence that neurotransmitters and hormones have on aggression, a genetic basis of violence can be expected in related genes. [76] , [106] , [107] For example, the influence of serotonin transporters [18] , [41] , [108] and receptors, [61] tryptophan hydroxylase, [2] , [77] MAO-A, [83] , [106] catechol-O-methyltransferase, [18] , [77] , [89] dopamine receptors, [17] , [41] , [86] – [88] , [104] , [107] the androgen receptor [64] , [95] , [109] and the corticotrophin releasing hormone receptor [110] have been mentioned. However, in a meta-analysis including these genes, no single gene was significantly correlated with aggression.…”

Section: Resultsmentioning

confidence: 99%

Neurobiological Correlates in Forensic Assessment: A Systematic Review

Gronde

Kempes

et al. 2014

PLoS ONE

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BackgroundWith the increased knowledge of biological risk factors, interest in including this information in forensic assessments is growing. Currently, forensic assessments are predominantly focused on psychosocial factors. A better understanding of the neurobiology of violent criminal behaviour and biological risk factors could improve forensic assessments.ObjectiveTo provide an overview of the current evidence about biological risk factors that predispose people to antisocial and violent behaviour, and determine its usefulness in forensic assessment.MethodsA systematic literature search was conducted using articles from PsycINFO, Embase and Pubmed published between 2000 and 2013.ResultsThis review shows that much research on the relationship between genetic predisposition and neurobiological alterations with aggression is performed on psychiatric patients or normal populations. However, the number of studies comparing offenders is limited. There is still a great need to understand how genetic and neurobiological alterations and/or deficits are related to violent behaviour, specifically criminality. Most studies focus on only one of the genetic or neurobiological fields related to antisocial and/or violent behaviour. To reliably correlate the findings of these fields, a standardization of methodology is urgently needed.ConclusionFindings from the current review suggest that violent aggression, like all forms of human behaviour, both develops under specific genetic and environmental conditions, and requires interplay between these conditions. Violence should be considered as the end product of a chain of life events, during which risks accumulate and potentially reinforce each other, displaying or triggering a specific situation. This systematic review did not find evidence of predispositions or neurobiological alterations that solely explain antisocial or violent behaviour. With better designed studies, more correlation between diverse fields, and more standardisation, it might be possible to elucidate underlying mechanisms. Thus, we advocate maintaining the current case-by-case differentiated approach to evidence-based forensic assessment.

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“…They found that the COMT Val158Met polymorphism had no significant effect on the presence of aggression in the Korean schizophrenia sample; however they found the Met-allele carriers to score higher in verbal aggression within the aggressive schizophrenia subgroup. Koh et al [ 49 ] examined inpatients from a forensic psychiatric hospital in Korea. When they compared the frequencies of criminal or homicidal schizophrenia patients with healthy controls, they did not find Val158Met to be associated.…”

Section: Methodsmentioning

confidence: 99%

The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies

Qayyum¹,

Zai²,

Hirata³

et al. 2015

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Aggressive behaviors have become a major public health problem, and early-onset aggression can lead to outcomes such as substance abuse, antisocial personality disorder among other issues. In recent years, there has been an increase in research in the molecular and genetic underpinnings of aggressive behavior, and one of the candidate genes codes for the catechol-O-methyltransferase (COMT). COMT is involved in catabolizing catecholamines such as dopamine. These neurotransmitters appear to be involved in regulating mood which can contribute to aggression. The most common gene variant studied in the COMT gene is the Valine (Val) to Methionine (Met) substitution at codon 158. We will be reviewing the current literature on this gene variant in aggressive behavior.

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The Relation of Serotonin-Related Gene andCOMTGene Polymorphisms With Criminal Behavior in Schizophrenic Disorder

Abstract: These results indicate that the TPH1 CC recessive genotype is likely to be a genetic risk factor for criminal behavior, especially homicidal behavior in patients with schizophrenia. However, COMT gene polymorphisms were not associated with criminal behavior in schizophrenic patients.

Cited by 12 publications

References 0 publications

Functional −141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter and schizophrenia in a Chinese Han population

Functional −141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter and schizophrenia in a Chinese Han population

Neurobiological Correlates in Forensic Assessment: A Systematic Review

The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies

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