The relation of serum gamma-glutamyl transferase levels with coronary lesion complexity and long-term outcome in patients with stable coronary artery disease

Aksakal, Enbiya; Tanboğa, İbrahi̇m Hali̇l; Kurt, Mustafa; Kayğın, Mehmet Ali; Kaya, Ahmet; Işık, Turgay; Ekinci, Mehmet; Sevimli, Serdar; Açıkel, Mahmut

doi:10.1016/j.atherosclerosis.2012.01.044

Cited by 45 publications

(36 citation statements)

References 26 publications

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“…A recent study 442 consecutive patients with stable CHD showed a close correlation between GGT and severity and extent of coronary atherosclerosis assessed by the SYNTAX score (46). Similarly, another recent study that used computed tomography angiography to assess coronary plaque burden and structure in 259 young subjects with coronary atherosclerosis (138 patients with coronary atherosclerosis with a mean age of 41.6 years and 121 controls with a mean age of 41.9 years) showed that patients with plaque formation had significantly higher GGT levels than controls.…”

Section: Ggt and Coronary Events Or Mortality In Patients With Chdmentioning

confidence: 94%

Gamma-glutamyl transferase and cardiovascular disease

Ndrepepa¹,

Kastrati²

2016

Ann. Transl. Med.

103

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Gamma-glutamyl transferase (GGT) is an enzyme located on the external surface of cellular membranes. GGT contributes in maintaining the physiological concentrations of cytoplasmic glutathione and cellular defense against oxidative stress via cleavage of extracellular glutathione and increased availability of amino acids for its intracellular synthesis. Increased GGT activity is a marker of antioxidant inadequacy and increased oxidative stress. Ample evidence suggests that elevated GGT activity is associated with increased risk of cardiovascular disease (CVD) such as coronary heart disease (CHD), stroke, arterial hypertension, heart failure, cardiac arrhythmias and all-cause and CVD-related mortality. The evidence is weaker for an association between elevated GGT activity and acute ischemic events and myocardial infarction. The risk for CVD or CVD-related mortality mediated by GGT may be explained by the close correlation of GGT with conventional CVD risk factors and various comorbidities, particularly non-alcoholic fatty liver disease, alcohol consumption, oxidative stress, metabolic syndrome, insulin resistance and systemic inflammation. The finding of GGT activity in atherosclerotic plaques and correlation of intra-plaque GGT activity with histological indexes of plaque instability may suggest a participation of GGT in the pathophysiology of CVD, particularly atherosclerosis. However, whether GGT has a direct role in the pathophysiology of CVD or it is an epiphenomenon of coexisting CVD risk factors or comorbidities remains unknown and Hill's criteria of causality relationship between GGT and CVD are not fulfilled. The exploration whether GGT provides prognostic information on top of the information provided by known cardiovascular risk factors regarding the CVD or CVD-related outcome and exploration of molecular mechanisms of GGT involvement in the pathophysiology of CVD and eventual use of interventions to reduce circulating GGT activity remain a duty of future studies.

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Section: Ggt and Coronary Events Or Mortality In Patients With Chdmentioning

confidence: 94%

Gamma-glutamyl transferase and cardiovascular disease

Ndrepepa¹,

Kastrati²

2016

Ann. Transl. Med.

103

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“…It is able to aid revascularization decisions and predicts mortality and morbidity in patients with CAD (11)(12)(13)(14). The relationship between ABO blood group and the severity of CAD assessed by SS in patients with CAD has not been clearly determined.…”

Section: Introductionmentioning

confidence: 99%

Relation of ABO blood groups to coronary lesion complexity in patients with stable coronary artery disease: an observational study

Kaya¹,

Tanboğa²,

Kurt³

et al. 2013

Anadolu Kardiyol Derg

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Objective: We aimed to investigate the relationship between ABO blood groups and complexity of coronary lesions assessed by SYNTAX score (SS) in stable coronary artery disease (CAD) patients. Methods: Our cross-sectional and observational study population consisted of 559 stable CAD patients. From all patients, ABO blood group was determined and the SS was calculated as low SYNTAX score (0-22), intermediate SYNTAX (23-32) score and high SYNTAX score (>32). Statistical analysis was performed using Student's t-test or Mann-Whitney U test, ANOVA, or Kruskal-Wallis test and chi-square test. Multiple logistic regression analysis was used to identify the independent predictors of high SS. Results: The analysis between the SS tertiles revealed that the frequency of non-O blood group was significantly higher in the upper SS tertiles (56.2% vs. 75.9 vs. 80.2%, p<0.05). However, the frequencies of Rh types were similar in all tertiles. Multiple logistic regression analysis was applied for determining the predictors of high SS. Accordingly, non-O blood group (OR: 2.68, 95% CI 1.65-4.35, p<0.001), LV-EF (OR: 0.93, 95% CI 0.91-0.95, p<0.001), LDL(OR: 0.98, p<0.001), and e-GFR (OR: 0.99, 95% CI 0.98-0.98, p<0.001) were found to be the independent predictors of high SS. Conclusion: We showed that there were significant associations between ABO blood groups and complexity of angiographic CAD.

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“…Epidemiologic studies have reported that GGT is sig nifi cantly associated with cardiovascular mortality and stroke ( 16,17). Dogan et al showed a relationship between higher GGT concentrations and coronary atherosclerosis (18).…”

Section: Discussionmentioning

confidence: 99%

Vertebrobasilar insufficiency and gamma-glutamyltransferase: An emerging relationship demonstrating inflammation and atherosclerosis

Ms¹,

Beker‐Acay²,

S³

et al. 2016

BLL

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OBJECTIVES: Vertebrobasilar insuffi ciency (VBI) is a pathology arising from the reduction in fl ow rate of vertebral arteries and mainly caused by infl ammation and atherosclerosis. Gamma-glutamyltransferase (GGT) is a marker which has been recently recognized as a marker of infl ammation and atherosclerosis. We aimed to investigate the relationship between GGT levels and VBI for the fi rst time. METHODS: In this cross-sectional study, of 3100 subjects who had vertebrobasilar doppler ultrasonography (VBU) were evaluated and 1042 of them who met the inclusion criterias were included. VBU reports, GGT levels, blood chemistry, lipid profi le were received from patients' fi les. Patients were evaluated according to VBU measurements and divided into two groups,VBI and non-VBI. RESULTS: Mean vertebral arterial blood fl ow volume values were 149.99±32.93 mL/m in VBI group and 286.88 ± 70.98 mL/m in non-VBI group. Mean GGT and CRP values were signifi cantly higher in the VBI group than in the non-VBY group (p < 0.001) ( p < 0.001), respectively. Vertebral artery blood fl ow volume was negatively correlated with GGT (r: -0.208, p < 0.001) and CRP (r: -0.119, p < 0.001). CONCLUSION: We demonstrated a signifi cant correlation between serum GGT levels and VBI. In addition, higher GGT level was an independent risk factor for the presence of vertebrobasilar system infl ammation and atherosclerosis (Tab. 2, Fig. 3, Ref. 27). Text in PDF www.elis.sk.

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The relation of serum gamma-glutamyl transferase levels with coronary lesion complexity and long-term outcome in patients with stable coronary artery disease

Cited by 45 publications

References 26 publications

Gamma-glutamyl transferase and cardiovascular disease

Gamma-glutamyl transferase and cardiovascular disease

Relation of ABO blood groups to coronary lesion complexity in patients with stable coronary artery disease: an observational study

Vertebrobasilar insufficiency and gamma-glutamyltransferase: An emerging relationship demonstrating inflammation and atherosclerosis

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