The relation of sleep difficulties to fatigue, mood and disability in chronic fatigue syndrome

Morriss, Richard; Wearden, Alison; Battersby, L.

doi:10.1016/s0022-3999(97)89895-9

Cited by 68 publications

(46 citation statements)

References 12 publications

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“…28,29 CFS/ME patients are found to have more self-reported awakenings during sleep due to pain compared to depressed patients and healthy controls. 32 On the other hand, sleep disturbance also leads to reduced pain thresholds during waking. 30 Pain and fatigue symptoms, similar to those reported in CFS/ME and FM, have been induced in healthy individuals by disrupting SWS.…”

Section: Differential Diagnosesmentioning

confidence: 99%

“…Studies that have explored this potential link by comparing sleep study results of CFS/ME patients with and without a psychiatric comorbidity suggest that sleep disturbances are common in both subtypes, and therefore do not appear to be solely the result of underlying depression. 4,32 All of these studies mentioned above have been critical for highlighting CFS/ME as an autonomous syndrome. Table 1 presents studies that have compared sleep parameters of CFS/ME patients to healthy controls using polysomnography.…”

Section: Differential Diagnosesmentioning

confidence: 99%

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Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Jackson

Bruck

2012

Journal of Clinical Sleep Medicine

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Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ ME) is a chronic, disabling illness that affects approximately 0.2% of the population. Non-restorative sleep despite sufficient or extended total sleep time is one of the major clinical diagnostic criteria; however, the underlying cause of this symptom is unknown. This review aims to provide a comprehensive overview of the literature examining sleep in CFS/ ME and the issues surrounding the current research fi ndings. Polysomnographic and other objective measures of sleep have observed few differences in sleep parameters between CFS/ME patients and healthy controls, although some discrepancies do exist. This lack of signifi cant objective differences contrasts with the common subjective complaints of disturbed and unrefreshed sleep by CFS/ME patients. The emergence of new, more sensitive techniques that examine the microstructure of sleep are showing promise for detecting differences in sleep between patients and healthy individuals. There is preliminary evidence that alterations in sleep stage transitions and sleep instability, and other physiological mechanisms, such as heart rate variability and altered cortisol profi les, may be evident. Future research investigating the etiology of non-restorative sleep in CFS/ME may also help us to undercover the causes of non-restorative sleep and fatigue in other medical conditions. keywords: Chronic fatigue syndrome, myalgic encephalomyelitis, sleep, non-restorative sleep, sleep disorders, fatigue, sleepiness Citation: Jackson ML; Bruck D. Sleep abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a review.

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Section: Differential Diagnosesmentioning

confidence: 99%

Section: Differential Diagnosesmentioning

confidence: 99%

Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Jackson

Bruck

2012

Journal of Clinical Sleep Medicine

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“…To our knowledge, no attempts have been made to study lack of recovery through sleep in a clinically burned-out sample and to relate it to sleep quality. In a syndrome that bears some parallelism with burnout [chronic fatigue syndrome (CFS)], sleep problems are prominent as well [13] and were found to be a complicating factor with respect to health recovery [14]. When sleep problems do not resolve while off work and when they hinder the onset of recovery, this may sustain the state of energy depletion.…”

Section: Recovery From Fatigue Through Sleepmentioning

confidence: 99%

Evidence that impaired sleep recovery may complicate burnout improvement independently of depressive mood

Sonnenschein

Sorbi

Doornen

et al. 2007

Journal of Psychosomatic Research

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“…Each 30 sec epoch of data was analyzed in 2 second blocks that were recombined to provide values for 5 frequency bands: delta (0.5-4 Hz), theta (4-8 Hz), alpha (8)(9)(10)(11)(12) Hz), sigma (12-16 Hz), and beta (> 16 Hz). This analysis was performed for both left (C3) and right (C4) hemisphere central electrode sites.…”

Section: Eeg Quantificationmentioning

confidence: 99%

“…Also, there is no consensus as to the underlying pathophysiology of the disease [7,8]. Along with excessive daytime fatigue, symptoms of insomnia and insufficient, non-restorative sleep are among the most common and disabling complaints [4][5][6][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Aspects of Slow-Wave EEG Activity During Sleep in Twins Discordant for Chronic Fatigue Syndrome

Goldberg¹,

Watson²,

Buchwald³

et al. 2009

TOSLPJ

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Chronic Fatigue Syndrome (CFS) is a disease characterized by high levels of daytime fatigue. Complaints such as unrefreshing sleep and insomnia are common. Polygraphic studies of sleep in CFS patients have found evidence of disturbed sleep, but controls in these studies were often not adequate to evaluate differences specific to CFS. Watson, et al.[1] and Ball, et al.[2] used a co-twin control design to eliminate virtually all sources of confounding variance and found a small difference between levels of Stage 2 sleep (lower in CFS) and Stage 3 sleep (higher in CFS), where CFS ill twins showed a higher level of sleep complaint than the healthy twins which was not reflected in their sleep physiology. The current study will apply more sensitive measures of sleep EEG to these data to examine differences more closely. A cotwin control study was performed on 10 pairs of identical twins discordant for CFS. Data from the second sleep night were analyzed using fast-fourier analysis (FFT) and finally measures of slow-wave activity (SWA). Data for NREM periods was analyzed. There was a significant interaction in SWA for Twin x NREM period for the first 2 NREM periods with the healthy twins having more SWA in the first NREM period and less in the second NREM period. While overall SWA activity did not differentiate the groups, the distribution of SWA in the first 2 NREM periods could be associated with the experience of unrefreshing sleep. Typically, SWA in the first NREM period is associated with deep restorative sleep. Lower SWA in NREMP 1 in the ill CFS twins suggests that this process is compromised resulting in the experience of less refreshing sleep.

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The relation of sleep difficulties to fatigue, mood and disability in chronic fatigue syndrome

Cited by 68 publications

References 12 publications

Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Sleep Abnormalities in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Review

Evidence that impaired sleep recovery may complicate burnout improvement independently of depressive mood

Aspects of Slow-Wave EEG Activity During Sleep in Twins Discordant for Chronic Fatigue Syndrome

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