The Relation of the Hypophysis to Diabetes Mellitus1

Colwell, Arthur R.

doi:10.1097/00005792-192702000-00001

Cited by 19 publications

(1 citation statement)

References 11 publications

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“…(1,2). In acromegaly this impairment may be so severe as to produce the disease " diabetes mellitus" (15); the one case of this type in Table III (17) and others. In almost all the normal subjects the blood sugar fell below its fasting level within two hours after the injection of glucose, and in this sense some measure of hypoglycemia is physiological.…”

Section: Results (A) Analysis Of Results In Sixty Normal Subjectsmentioning

confidence: 99%

The Intravenous Glucose Tolerance Test

Lozner¹,

Winkler²,

Taylor³

et al. 1941

J. Clin. Invest.

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Oral glucose tolerance tests have generally been used to differentiate between diabetes mellitus and the various forms of non-diabetic glycosuria (1).On the basis of such oral tests alterations in carbohydrate metabolism have also been reported in numerous disorders other than diabetes mellitus. These include endocrine, intracranial and hepatic diseases (2), arthritis (3), and convulsive disorders of various types (4). Oral METHODSSixty normal adult subjects were studied. All were in the post-absorptive state and remained in a recumbent position throughout the morning. After a fasting venous blood sample had been obtained, 50 ml. of a 50 per cent solution of glucose in distilled water were injected intravenously during a period of two minutes. Samples of venous blood were obtained at intervals during the next two or three hours. In the majority of cases hourly urine samples were collected as well. A modification of Benedict's macro-method (6) was used for blood sugar analyses, protein-free filtrates of whole blood being employed. Protein was removed by the zinc precipitation method of Somogyi (7), which also removes most of the non-fermentable reducing substances. Rothberg and Evans' (8) tubes were used in the final visual colorimetric comparison. Urine samples were analyzed for glucose by the quantitative method of Benedict (9).The same procedure was applied to 271 patients in the New Haven Hospital. Only a few with outright diabetes were included. The majority were selected either because, on clinical grounds, some abnormality of carbohydrate metabolism was suspected or because they had some one of a variety of disorders reputedly attended by derangement of carbohydrate metabolism.RESULTS

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Section: Results (A) Analysis Of Results In Sixty Normal Subjectsmentioning

confidence: 99%