The Relation of the Thyroid to the Hypophysis and Ovary*

Horn, W

doi:10.1210/endo-17-2-152

Cited by 52 publications

(8 citation statements)

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“…The action of thyroid hormone on ovarian function is probably a complex one, and effects on pituitary release on gonadotrophins, ovarian sensitivity, and peripheral inactivation both of gonadotrophin and of oestrogen have all been suggested (Jones & Ball, 1962). Nevertheless, there seems general agreement with Van Horn (1931) and Chu & You (1945) that thyroid-fed animals show inhibition of oestrous cycles, at least with large doses, and a high pituitary concentration of gonadotrophin. In this connexion it is significant that in the third and fourth week of life, when the metabolic rate of the rat rises to about twice the adult level (Brody, 1945) the concentration of gonadotrophin in the pituitary rises to a value many times that in the adult gland (Lauson, Golden & Sevringhaus, 1939).…”

Section: Discussionmentioning

confidence: 69%

Body weight and food intake as initiating factors for puberty in the rat

Kennedy¹,

Mitra²

1963

The Journal of Physiology

423

211

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Section: Discussionmentioning

confidence: 69%

Body weight and food intake as initiating factors for puberty in the rat

Kennedy¹,

Mitra²

1963

The Journal of Physiology

423

211

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“…In this condition Weichert and Boyd (1933) were able to elicit the decidual response by uterine trauma, and they suggest the possibility of increased pituitary stimulation of the ovaries under the treatment. That thyroid feeding does increase the gonad-stimulating power of the anterior pituitary has been shown by Evans and Simpson (1930) and by Van Horn (1933).…”

Section: Deciduoma Formation After Unspecific Inhibition O F Folliclementioning

confidence: 70%

“…One of the most striking instances results from the administration of desiccated thyroid. Numerous investigators have seen that this can lead to the suppression of the cycle (Cameron and Amies, 1926;Reiss and Pereny, 1928) and to prolonged corpus luteum activity (Weichert, 1930;Weichert and Boyd, 1933;Van Horn, 1933;and Campbell, Wolfe, and Phelps, 1934). In this condition Weichert and Boyd (1933) were able to elicit the decidual response by uterine trauma, and they suggest the possibility of increased pituitary stimulation of the ovaries under the treatment.…”

Section: Deciduoma Formation After Unspecific Inhibition O F Folliclementioning

confidence: 99%

Studies on the physiology of the maternal placenta in the rat

Selye

McKeown

1935

Proc. R. Soc. Lond. B

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[Plates 1-6]Although a great many investigators have made adequate studies on the maternal placenta from the morphogenetic point of view, little attention has so far been given to the humoral conditions which make the formation of the placenta materna possible. Experimental investigations of the problems of placental physiology have as yet been few, and leave unanswered many important questions. Which are the factors deter mining the life span of the placenta, and what is responsible for its ageing ? In what way are the pregnancy changes influenced by the three structures -maternal placenta, foetal placenta, and embryo-present during gesta tion, and what is the role of each ?Recent advances in the physiology of reproduction have made it possible to attempt the elucidation of these problems under unusually favourable conditions. Of great importance was the observation of Leo Loeb that the maternal placenta could be produced experimentally in the rodent. Furthermore, we have reported experiments which showed that the embryos could be removed from the pregnant rat and mouse without interfering with the development of either the foetal or the maternal placenta. These facts, together with the important progress of the past few years in the physiology of the female sex hormones in general, have formed the basis for our present studies, and have enabled us to elucidate some of the problems indicated above.Many of the observations on the physiology of the maternal placenta have been presented in the literature as incidental findings, rather than as the product of a direct investigation. It is obviously of importance that these findings should be correlated, and since no attempt has pre viously been made to do this, we have thought it worth while to review the literature as completely as possible.

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“…Hypothyroidism has been reported to favour pregnancy (Johnson & Meites, 1950;Wilson & Chai, 1962), but it has also been said to be disadvantageous (Williams, Weinglass, Bissel & Peters, 1944;Peterson, Webster, Rayner Sc Young, 1952;Janes & Bradbury, 1952); and without effect (Desaive, 1948;Krohn, 1951). The effects reported for hyperthyroidism are equally conflicting (Hoar, Goy & Young, 1951;Peterson et al, 1952).…”

Section: Introductionmentioning

confidence: 99%

Effect of Thyroid Activity Upon Delayed Implantation of Blastocysts in the Rat

Holland¹,

Dorsey²,

Harris³

et al. 1967

Reproduction

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The effects of l-thyroxine and of surgical thyroidectomy upon the survival of blastocysts have been studied in 200 albino rats. These rats were ovariectomized on the 3rd day of pregnancy, and maintained on progesterone in order to delay implantation. Delay of implantation was confirmed by laparotomy on the 8th day of pregnancy. Subsequent implantation was accomplished by giving 1 \ g=m\ g oestrone daily from the 9th day of pregnancy. At autopsy on the 14th day of pregnancy hyperthyroid rats and hypothyroid rats which had been maintained on daily injections of 2\m=.\0 mg progesterone did not differ from their respective control groups in the number of surviving blastocysts. However, hyperthyroid rats which had been maintained on daily injections of 0\m=.\4mg progesterone possessed more implantation sites than controls. Similarly, the hypothyroid rats maintained on daily injections of 0\m=.\3 mg progesterone had fewer implantation sites than controls. The experiments suggest that the level of hyperthyroidism tested is beneficial to the maintenance of implantation of delayed blastocysts when low amounts of progesterone are available, while hypothyroidism tends to be detrimental to this process during low progesterone availability.

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The Relation of the Thyroid to the Hypophysis and Ovary*

Cited by 52 publications

References 0 publications

Body weight and food intake as initiating factors for puberty in the rat

Body weight and food intake as initiating factors for puberty in the rat

Studies on the physiology of the maternal placenta in the rat

Effect of Thyroid Activity Upon Delayed Implantation of Blastocysts in the Rat

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