2011
DOI: 10.3346/jkms.2011.26.4.540
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The Relation of Thyroid Function to Components of the Metabolic Syndrome in Korean Men and Women

Abstract: This study was to assess the relation of thyroid dysfunction to metabolic syndrome (MetS) at an earlier stage in Korean population. Metabolic parameters such as body composition, blood pressure (BP), fasting glucose, total cholesterol, triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), thyroid-stimulating hormone (TSH) and free thyroxine 4 (fT4) were measured. During a mean follow-up of 3 yr, 5,998 Koreans ages over 18 yr were assessed. There were 694 cases of MetS at follow-up. The mean age … Show more

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Cited by 79 publications
(81 citation statements)
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“…In support of this possibility, we observed that blood pressure and lipid levels increased among people with an increase in TSH levels during follow-up, but decreased among people with a decrease in TSH levels. Similar to these results, an increase in TSH levels was positively associated with an increase in blood pressure, cholesterol and triglyceride levels in a 3-year follow-up study of almost 6000 individuals (23).…”
Section: Discussionsupporting
confidence: 71%
“…In support of this possibility, we observed that blood pressure and lipid levels increased among people with an increase in TSH levels during follow-up, but decreased among people with a decrease in TSH levels. Similar to these results, an increase in TSH levels was positively associated with an increase in blood pressure, cholesterol and triglyceride levels in a 3-year follow-up study of almost 6000 individuals (23).…”
Section: Discussionsupporting
confidence: 71%
“…In younger populations, associations with other components of the metabolic syndrome such as TC, triglycerides, blood pressure, and waist circumference were observed (5,6,7,8,9). In subgroup analyses of persons 70 years and older, Asvold et al found a significant association between serum TSH and blood pressure (diastolic blood pressure in men and women, and systolic blood pressure only in women).…”
Section: Discussionmentioning
confidence: 91%
“…In two cross-sectional studies performed in euthyroid people, serum TSH was associated with higher triglycerides and an increased risk of the metabolic syndrome (6,7). Another study with a follow-up period of 3 years found that serum TSH was associated with increased triglycerides, TC, waist circumference, and blood pressure, and decreased HDL, TC, waist circumference, and blood pressure and that subjects with metabolic syndrome had an increased serum TSH over time (8).…”
Section: Introductionmentioning
confidence: 99%
“…First, the cross-sectional design does not permit cause-effect conclusions. To our best knowledge, similar longitudinal studies like the cited one are rare (27). Second, a determination of insulin sensitivity would throw more light on the discussed associations, but it could not be implemented in the current population-based study.…”
Section: Discussionmentioning
confidence: 99%