Context: Psychological disorders, such as depression and anxiety, are common among young people with substance misuse. Preventive strategies can diminish the negative impact on the society, especially family function. Objectives: The objective of this study was to systematically review the family functions in the risk of serious mental illness among youth with substance misuse. Methods: The main databases Web of Science, PubMed, and SCOPUS were searched for studies published during January 2018-December 202. “Prevention”, “anxiety”, “coping”, “family”, “parents”, “patients care plan”, “adjustment”, “community”, “youth”, and “drug addiction” were the keywords searched in the databases. The present review was conducted in 2022. Results: After the screening of articles based on the exclusion criteria, we selected seven studies. The studies were classified as affianced, patience, pulling out, social support, and emotional stability actions. Society and parents, who are the core family members, feel anxious following the drug misuse of the youth. The youngsters felt that these substances were harmful for their health, especially reproductive health. The parents felt very secluded from family and friends. There are different preventive strategies to overcome this behavior. Conclusions: Results of different evaluated studies showed that using emotional strategy is the common tool to prevent substance abuse. Social status and cultural perspective are effective in preventing this issue.