Human and natural physical-caused climate variation can affect climate extremes, also called maximum high temperature. The change of the inter-annual maximum temperatures has been studied between1981 to 2016. Annual Maximum Temperatures (AMT) data consists of the temperature study of 36 years. The analysis of the correlation between the Badin, Karachi, Quetta, Lahore, and Peshawar, Islamabad temperature data and the explanatory variable such as Global Annual Mean-Land-Ocean Temperature Index (GAMLOTI), annual carbon dioxide (ACD), and North Atlantic Oscillation (NAO) teleconnection arrangement in annual maximum temperature indicated between explanatory variable is significant. Therefore, the correlation between the Badin (AMT) and the GAMLOTI is significant with the relationship of correlation coefficient 0.127 at the level of significance 0.05, and the index of NAO is negative significant correlation (r =−0.151), and the correlation between Islamabad and Karachi's annual maximum temperature and the explanatory variable is insignificant. The results of multiple regression analysis showed that the whole effect of global annual change means land-ocean temperature index GAMLOTI, the annual concentration of atmospheric carbon dioxide ACD, and the north Atlantic oscillation NAO index on the temporal variabilities of Badin, Quetta, Islamabad, Karachi, and Peshawar during the 36-year period. The variations occur R 2 45.7%, 51.3%, 43.1%, 46%, and 48.1%. The relationship between the AMT and the GAMLOTI and the annual concentration of ACD represent the global warming, mostly effects on the variability of AMT.