The relationship among gastroparetic symptoms, quality of life, and gastric emptying in patients referred for gastric emptying testing

DiBaise, John K.; Patel, Nihal; Noelting, Jessica; Dueck, Amylou C.; Roarke, Michael C.; Crowell, Michael D.

doi:10.1111/nmo.12718

Cited by 38 publications

(30 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding the scintigraphic evaluation, the discordance rate was 21%, but in all the cases but one, the gap was in favour of a clinical improvement despite still disturbed GES. This could be explained by the sensibility of this examination, known to be imperfect, even if a disturbed GES is correlated with the severity of the disorder . Interestingly, all the discordances were observed in case of idiopathic gastroparesis.…”

Section: Discussionmentioning

confidence: 97%

G‐POEM with antro‐pyloromyotomy for the treatment of refractory gastroparesis: mid‐term follow‐up and factors predicting outcome

Gonzalez

Benezech

Vitton

et al. 2017

Aliment Pharmacol Ther

140

117

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

G‐POEM with antro‐pyloromyotomy for the treatment of refractory gastroparesis: mid‐term follow‐up and factors predicting outcome

Gonzalez

Benezech

Vitton

et al. 2017

Aliment Pharmacol Ther

140

117

View full text Add to dashboard Cite

show abstract

“…Similar associations between vomiting, early satiety, and delayed gastric emptying were also observed in other gastric motility disorders, such as gastroparesis. DiBaise et al [18] demonstrated that severities of postprandial fullness/early satiety and nausea/ emesis, but not the bloating, in gastroparesis were correlated with severity of gastric emptying delay measured by scintigraphy. Furthermore, a prospective study by Ron et al [19] in 111 consecutive gastroparesis patients showed that only early satiety was associated with delayed gastric emptying measured by breath test.…”

Section: Discussionmentioning

confidence: 99%

Gastroduodenal Symptoms in Inflammatory Bowel Disease Are Correlated with Gastric Emptying and Serum Levels of Active Ghrelin

Sales

Cavalcanti

Souza

et al. 2019

Dig Dis

View full text Add to dashboard Cite

Background: Inflammatory bowel disease (IBD) is associated with delay in gastric emptying, increase in ghrelin, and decrease in leptin. The aim was to investigate the correlation between gastroduodenal (GD) symptoms, gastric emptying, and serum levels of active ghrelin and leptin in IBD. Twenty-seven IBD patients and 26 healthy volunteers were asked to complete the Porto Alegre Dyspeptic Symptoms Questionnaire. A gastric emptying test for solids was performed using a C13 octanoic acid breath test. During this test, serum samples were collected for measuring active ghrelin and leptin concentrations by radioimmunoassay. Summary: Patients with IBD demonstrated delayed gastric emptying compared with healthy volunteers. In patients with GD symptoms, the delay in gastric emptying was more pronounced, and there were significant correlations of satiety and vomiting with gastric emptying. Basal leptin, but not active ghrelin, increased in patients with GD symptoms compared with patients without these symptoms. There were negative correlations between basal active ghrelin with total Porto Alegre score and epigastric pain in IBD patients with GD symptoms. Key Messages: In IBD, satiety and vomiting were associated with delay in gastric emptying. Conversely, epigastric pain had a negative correlation with active ghrelin. Our results suggest that different pathophysiological mechanisms contribute to GD symptoms in IBD.

show abstract

“…The poor correlation between symptoms and objective measures of gastric emptying is well known. 6,27,28 Thus, the decision to offer the individual diabetes patient GES was based on a history of recurrent nausea and/or vomiting and not on a strict diagnosis of GP. GES is a relatively expensive procedure, mainly because of the price of the electrode and battery, which is approximately €13.000.…”

Section: Discussionmentioning

confidence: 99%

“…5 The majority of diabetes patients with delayed gastric emptying remain asymptomatic, and severe symptoms can be present even if gastric emptying tests are normal. 6 Thus, treatment is usually initiated based on recurrent episodes of nausea and/or vomiting rather than a diagnosis of GP based on gastric emptying tests. Dietary modifications are the first line of intervention for recurrent nausea and/or vomiting in diabetes patients.…”

Section: Introductionmentioning

confidence: 99%

Early Assessment of Cost-effectiveness of Gastric Electrical Stimulation for Diabetic Nausea and Vomiting

Klinge

Rask

Mortensen

et al. 2017

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/AimsRecurrent nausea and/or vomiting are common complications of diabetes mellitus. The conditions severely impact the quality of life of patients and often cause repeated admissions to hospital incurring significant healthcare costs. If standard treatment fails, gastric electrical stimulation (GES) may be offered in selected cases, as a minimally invasive, but expensive, therapeutic option. Our aims are to evaluate the clinical effect and the cost-utility of GES as a treatment for severe diabetic recurrent nausea and/or vomiting. MethodsAmong 33 diabetes patients implanted with GES because of recurrent nausea and/or vomiting, 30 were available for evaluation. The effect of treatment was assessed prospectively using symptom-diaries and the SF-36 questionnaires at baseline, after 6 and 12 months, and thereafter yearly. The number of days in hospital due to symptoms related to gastrointestinal dysfunction was calculated using hospital records 12 months prior to and 12 months after implantation. ResultsThe surgical procedures were performed without mortality or major complications. Six months after surgery 78% of the respondents had at least 50% reduction in time with nausea and 48% had at least 50% reduction in days with vomiting. Symptom relief persisted at follow-up after at least 4 years. Quality adjusted life years improved after GES, which was cost-effective after 24 months. Conclusions

show abstract

The relationship among gastroparetic symptoms, quality of life, and gastric emptying in patients referred for gastric emptying testing

Abstract: In patients referred for GET, gastroparetic symptoms were more severe in those with delayed emptying. A decrease in quality of life in those with delayed gastric emptying was also present; this was not related to the severity of the delay in gastric emptying.

Cited by 38 publications

References 28 publications

G‐POEM with antro‐pyloromyotomy for the treatment of refractory gastroparesis: mid‐term follow‐up and factors predicting outcome

G‐POEM with antro‐pyloromyotomy for the treatment of refractory gastroparesis: mid‐term follow‐up and factors predicting outcome

Gastroduodenal Symptoms in Inflammatory Bowel Disease Are Correlated with Gastric Emptying and Serum Levels of Active Ghrelin

Early Assessment of Cost-effectiveness of Gastric Electrical Stimulation for Diabetic Nausea and Vomiting

Contact Info

Product

Resources

About