2001
DOI: 10.2337/diacare.24.10.1805
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The Relationship Among Homocysteine, Creatinine Clearance, and Albuminuria in Patients With Type 2 Diabetes

Abstract: OBJECTIVE—Although it is accepted that elevated plasma homocysteine (tHcy) levels occur in end-stage renal disease and type 2 diabetes, the changes with milder renal dysfunction (e.g., microalbuminuria) are less clearly established. This study explores the relationship among tHcy, creatinine clearance (Ccr), and albumin excretion rate (AER) in a population with type 2 diabetes. RESEARCH DESIGN AND METHODS—A total of 260 patients with type 2 diabetes were screened in our outpatient clinic during … Show more

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Cited by 66 publications
(58 citation statements)
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“…The association of increased tHcy concentrations with age [15], diabetic retinopathy [35], and nephropathy has been shown to be closely related to declining GFR below a normal value of 80 ml·min·(1.73 m 2 ) -1 [35,36]. After adjustment for GFR, tHcy remained a strong predictor for CHD disease in normotensive Type II diabetic patients, but not for diabetic nephropathy [35,36] or retinopathy [35]. Our data from a larger number of study patients confirms these findings.…”
Section: Discussionsupporting
confidence: 79%
See 1 more Smart Citation
“…The association of increased tHcy concentrations with age [15], diabetic retinopathy [35], and nephropathy has been shown to be closely related to declining GFR below a normal value of 80 ml·min·(1.73 m 2 ) -1 [35,36]. After adjustment for GFR, tHcy remained a strong predictor for CHD disease in normotensive Type II diabetic patients, but not for diabetic nephropathy [35,36] or retinopathy [35]. Our data from a larger number of study patients confirms these findings.…”
Section: Discussionsupporting
confidence: 79%
“…Adjustment of the study results for GFR, the more sensitive predictor of renal function, however, has been done by only a few investigators recently. The association of increased tHcy concentrations with age [15], diabetic retinopathy [35], and nephropathy has been shown to be closely related to declining GFR below a normal value of 80 ml·min·(1.73 m 2 ) -1 [35,36]. After adjustment for GFR, tHcy remained a strong predictor for CHD disease in normotensive Type II diabetic patients, but not for diabetic nephropathy [35,36] or retinopathy [35].…”
Section: Discussionmentioning
confidence: 88%
“…Several studies have reported that in patients with type 2 diabetes, elevated plasma tHcy is also associated with increased prevalence of CVD (22,23). Furthermore, previous studies have reported that plasma concentrations of tHcy are elevated in type 2 diabetic patients, especially those with diabetic nephropathy (24,25). We also found that plasma concentrations of tHcy were significantly higher in diabetic patients than in control subjects.…”
Section: Discussionsupporting
confidence: 72%
“…We and other investigators have reported that GFR is a major determinant of Hcy levels in the general population as well as in patients with CKD. 1,11,39,40 In the present study, adjustment for GFR attenuated most of the relationship between tHcy and mortality, suggesting that GFR was the primary confounder for the observed association of high tHcy levels and the mortality end points. Reduced GFR is a known important risk factor for CVD 10 ; thus, the varied measurement and adjustment for kidney function in prior literature may largely explain the heterogeneity of study results.…”
Section: Discussionmentioning
confidence: 74%