The Relationship Among Thromboelastography, Hemostatic Variables, and Bleeding After Cardiopulmonary Bypass Surgery in Children

“…10,11 Moreover, only a few researches have studied the correlation between TEG and conventional clotting tests. 12,13 Thus, in this study, we planned to observe the preoperative coagulation changes measured by TEG and routine coagulation tests in patients with localized prostate cancer. Moreover, we compared the data obtained by routine laboratory coagulation analysis with TEG tracing values in order to find a correlation between the 2 methods.…”

Section: Introductionmentioning

confidence: 99%

Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer

Wang

Li²,

Cao

et al. 2017

Clin Appl Thromb Hemost

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We aimed to examine hypercoagulable and hypocoagulable conditions in patients with prostate cancer using thromboelastography (TEG) and correlate TEG parameters with conventional coagulation test. The t test was used for comparing TEG parameters and routine coagulation results. Spearman rank-order correlation was used to describe the relationship of TEG and conventional tests. Sensitivity, specificity, positive predictive values, and negative predictive values were determined for bleeding and thrombosis. Totally, 20 patients had active bleeding postoperatively, 16 of whom showed hypocoagulation on TEG test and 9 of whom showed hypocoagulation by routine coagulation test (P ¼ .024). Overall, 60 patients did not have active bleeding postoperatively, 51 of whom showed hypercoagulation detected by TEG test and 42 of whom showed hypercoagulation found by routine coagulation test (P ¼ .040). Remarkably, patients had a little higher fibrinogen (FIB) compared to controls. There was no statistical difference in any of the conventional coagulation indexes between the groups. Correlation analysis showed that reaction time (R) and coagulation time (K) were positively correlated with the prothrombin time-international normalized ratio (PT-INR) and negatively correlated with FIB (P < .001). Contrarily, a-angle and maximum amplitude (MA) were negatively correlated with PT-INR but positively correlated with FIB. Significantly, MA showed the strongest correlation with FIB and R exhibited the strongest correlation with PT-INR. Sensitivity and specificity for bleeding and thrombosis in TEG were higher than those in conventional coagulation test. Accordingly, TEG might be superior in evaluating hypercoagulation and detecting the risk of bleeding in patients with prostate cancer.

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“…A large volume of FFP (15-20 mL•kg -1 ) for restoring fibrinogen to an appropriate level is also problematic [11,15]. Therefore, ROTEMguided administering fibrinogen concentrate (FC) or cryoprecipitate can be more sophisticated management of hypofibrinogenemia in patients undergoing cardiac surgery.…”

Section: Discussionmentioning

confidence: 99%

Rotational Thromboelastometry as a Routine Point-of-Care Test Immediately after Cardiopulmonary Bypass Facilitated Earlier Diagnosis of Unexpected Hyperfibrinolysis and Hypofibrinogenemia During Cardiac Surgery

Кwon¹,

Oh²,

Kang³

et al. 2016

Int J Surg Surgical Proced

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The Relationship Among Thromboelastography, Hemostatic Variables, and Bleeding After Cardiopulmonary Bypass Surgery in Children

Abstract: Hypofibrinogenemia and inadequate heparin reversal are 2 important factors contributing to clot strength and perioperative hemorrhage after pediatric CPB. TEG may be a useful tool for predicting and guiding early treatment of mediastinal bleeding in this group.

Cited by 97 publications

References 38 publications

Thromboelastography—does it impact blood component transfusion in pediatric heart surgery?

Thromboelastography—does it impact blood component transfusion in pediatric heart surgery?

Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer

Rotational Thromboelastometry as a Routine Point-of-Care Test Immediately after Cardiopulmonary Bypass Facilitated Earlier Diagnosis of Unexpected Hyperfibrinolysis and Hypofibrinogenemia During Cardiac Surgery

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