The Relationship between 25-hydroxyvitamin D Levels, Insulin Sensitivity and Insulin Secretion in Women 3 Years after Delivery

Tänczer, Tímea; Magenheim, R; Furst, A.; Domján, Beatrix; Janicsek, Z; Szabó, Eszter; Ferencz, Viktória; Tabák, Ádám G.

doi:10.1016/j.jcjd.2017.01.003

Cited by 4 publications

(12 citation statements)

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“…Finally, 68 studies were full text screened, but only six met the inclusion criteria. Thus, a total of six studies were included in the review [ 17 , 18 , 19 , 20 , 21 , 22 ]. A flowchart of included studies is presented in Figure 1 , and a list of excluded studies after full text screening including reasons for their exclusion is presented in Supplementary Table S1 .…”

Section: Resultsmentioning

confidence: 99%

“…The six studies that met the criteria to be included in the present review were all conducted between 2012 and 2017 [ 17 , 18 , 19 , 20 , 21 , 22 ]. The characteristics of the six studies are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…For that reason, the decision was made not to exclude this study from the review. Out of the six studies, three were RCTs with two intervention arms, while one was a prospective study [ 22 ], one a cross-sectional [ 18 ] observational study, both including three comparison groups, and the final study was a nested case–control study [ 19 ]. All studies included pregnant women with a GDM diagnosis, vitamin D supplementation or concentration during or after pregnancy, and biomarkers associated with the risk of T2DM development.…”

Section: Resultsmentioning

confidence: 99%

“…In the three observational studies, vitamin D status was assessed with the measurement of (serum) 25(OH)D concentration at 1–2 years postpartum in the study by Shaat et al [ 18 ], at 3 months postpartum in the study by Kramer et al [ 22 ], and at 3.2 years postpartum in the study by Tänczer et al [ 19 ]. In the studies by Shaat et al [ 18 ] and Kramer et al [ 22 ], between-group comparisons of 25(OH)D concentrations based on the following cutoffs from the Endocrine Society guidelines: deficiency (<50 nmol/L), insufficiency 50–74 nmol/L, and sufficiency ≥75 nmol/L were made [ 23 ]; whereas 25(OH)D was used as a continuous variable in the study by Tänczer et al [ 19 ] ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

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The Role of Vitamin D in the Development of Diabetes Post Gestational Diabetes Mellitus: A Systematic Literature Review

et al. 2020

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Women diagnosed with gestational diabetes mellitus (GDM) are more likely to later develop diabetes. Evidence from some previous reviews suggests that low vitamin D status during pregnancy increases the risk of developing GDM, but whether vitamin D during pregnancy also influences the risk of diabetes post GDM is less well studied. Thus, the aim of this systematic literature review was to summarize the current available literature on that topic. This review considered observational studies and randomized controlled trials (RCTs). Five databases were searched. The risk of bias of the included studies was assessed. A total of six studies were included: three observational studies and three RCTs. Findings were inconsistent across the six included studies. However, when considering RCTs only, the findings more strongly suggested that vitamin D supplementation during and after pregnancy did not have an influence on markers of diabetes development or diabetes development post GDM. This systematic review highlights inconsistent findings on the associations between vitamin D supplementation or concentration during and after pregnancy and markers of diabetes development or diabetes development post GDM; and although results from randomized interventional studies more strongly suggested no associations, the conclusion holds a high degree of uncertainty.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The Role of Vitamin D in the Development of Diabetes Post Gestational Diabetes Mellitus: A Systematic Literature Review

et al. 2020

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“…We report the results of a case-control study performed between 2008 and 2010 nested within the cohort of women who delivered at Saint Margit Hospital (Budapest, Hungary) between 01/January/2005 and 31/December/2006. This hospital serves a mostly urbanized population in central Hungary with a catchment population of 235,000 people [11].…”

Section: Methodsmentioning

confidence: 99%

The Effect of Prior Gestational Diabetes on the Shape of the Glucose Response Curve during an Oral Glucose Tolerance Test 3 Years after Delivery

Tänczer

Svébis

Domján

et al. 2020

Journal of Diabetes Research

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Objective. Monophasic glucose response (MGR) during an oral glucose tolerance test (OGTT) and gestational diabetes mellitus (GDM) are predictors of type 2 diabetes mellitus (T2DM). We investigated the association between current MGR and (1) glucose tolerance during a pregnancy 3 years before and (2) current glucose tolerance status. We also sought (3) other determinants of MGR. Research Design and Methods. We conducted a nested case-control study of GDM (n=47 early GDM, diagnosed between 16 and 20 weeks of gestation; n=40 late GDM, diagnosed between 24 and 28 weeks of gestation) and matched healthy controls (n=37, normal glucose tolerance during pregnancy) all free from diabetes at follow-up 3.4±0.6 years after delivery. Glucose tolerance was determined by 2-hour 75 g OGTT. Monophasic and biphasic groups were defined based on serum glucose measurements during OGTT. Results. The biphasic group was younger, had lower triglyceride levels and area under the OGTT glucose curve, and was less frequently diagnosed with early GDM (25 vs. 45%, all p<0.05). Women with a biphasic response also tended to have lower systolic blood pressure (p<0.1). No differences were found in fasting and 2-hour glucose and insulin levels, or BMI. According to multiple logistic regression, MGR was associated with prior early GDM (OR 2.14, 95% CI 0.92-4.99) and elevated triglyceride levels (OR 2.28, 95% CI 1.03-5.03/log (mmol/l)). Conclusions. We found that more severe, early-onset GDM was an independent predictor of monophasic glucose response suggesting that monophasic response may represent an intermediate state between GDM and manifest type 2 diabetes.

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Therapies for gestational diabetes and their implications for maternal and offspring health: Evidence from human and animal studies

Brawerman

Dolinsky

2018

Pharmacological Research

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The Relationship between 25-hydroxyvitamin D Levels, Insulin Sensitivity and Insulin Secretion in Women 3 Years after Delivery

Cited by 4 publications

References 46 publications

The Role of Vitamin D in the Development of Diabetes Post Gestational Diabetes Mellitus: A Systematic Literature Review

The Role of Vitamin D in the Development of Diabetes Post Gestational Diabetes Mellitus: A Systematic Literature Review

The Effect of Prior Gestational Diabetes on the Shape of the Glucose Response Curve during an Oral Glucose Tolerance Test 3 Years after Delivery

Therapies for gestational diabetes and their implications for maternal and offspring health: Evidence from human and animal studies

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