The relationship between alpha asymmetry and ADHD depends on negative affect level and parenting practices

Alperin, Brittany R.; Smith, Christiana J.; Gustafsson, Hanna; Figuracion, McKenzie; Karalunas, Sarah L.

doi:10.1016/j.jpsychires.2019.06.016

Cited by 22 publications

(11 citation statements)

References 95 publications

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“…In another study, patients with ADHD showed significantly stronger anterior cortical activity in the left hemisphere in adults [32]. An additional study also revealed the relationship between ADHD and frontal alpha asymmetry, suggesting that ADHD severity could be predicted by right frontal alpha asymmetry [33]. These findings were consistent with our results.…”

Section: Discussionsupporting

confidence: 90%

Association Between Frontal Alpha Asymmetry With Cognitive Symptoms, Depression Severity, and Insomnia

Hwang

Kim²,

Park

2021

Chronobiol Med

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Objective: Previous studies have compared depressive episodes between bipolar disorder (BD) and major depressive disorder (MDD) using quantitative electroencephalogram (QEEG); however, there are no distinct discriminating feature between them. Here, we used QEEG to directly compare the alpha asymmetry and absolute power of each band between patients with BD and MDD.Methods: Fifty in-patients with major depressive episodes between 2019 and 2021 were retrospectively enrolled. Self-reported questionnaires including the Beck Depression Inventory (BDI), Korean version of the Childhood Trauma Questionnaire, and Adult Attention-Deficit/Hyperactivity Disorder Self Report Scale (ASRS) were used to evaluate the symptoms. The absolute power of QEEG delta, theta, alpha, beta, high beta waves, and the Z-scores of frontal alpha asymmetry were collected. A t-test and Pearson’s correlation test were conducted using these data and based on these results, an analysis of covariance was conducted.Results: There were no significant differences between MDD and BD in QEEG power or alpha asymmetry. Patients with severe depression (BDI ≥29) had higher alpha power at FP1 (p=0.037), FP2 (p=0.028), F3 (p=0.047), F4 (p=0.016), and higher right frontal alpha asymmetry at F3–F4 (p=0.039). Adult patients with features consistent with ADHD (ASRS ≥4) had higher right frontal alpha asymmetry at F3–F4 (p=0.046). Patients with insomnia had higher left frontal alpha asymmetry at F3–F4 (p=0.003).Conclusion: QEEG limited the differential diagnosis of MDD and BD. However, frontal alpha asymmetry did exist in depression and affected cognitive impairment, insomnia, and depression severity in particular. Future studies with improved methodologies are needed for a better comparison.

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Section: Discussionsupporting

confidence: 90%

Association Between Frontal Alpha Asymmetry With Cognitive Symptoms, Depression Severity, and Insomnia

Hwang

Kim²,

Park

2021

Chronobiol Med

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“…Frontal asymmetry has been previously reported in ADHD [ 28 , 60 ], but only a few studies examined frontal alpha asymmetry in ADHD. Alperin et al [ 61 ] in a large sample of young focused on the role of EEG to investigate patterns of atypical right asymmetry as a possible endophenotype of ADHD. Within the available studies, some reported right alpha symmetry across samples of patients with different ages [ 27 , 62 ], whereas others reported left alpha asymmetry [ 55 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Electroencephalographic and Neuroimaging Asymmetry Correlation in Patients with Attention-Deficit Hyperactivity Disorder

et al. 2020

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The present study explores the correlation between electroencephalographic and neuroimaging asymmetry index from EEG-MRI functional connectome and EEG power analysis in inattention, motion, and mixed profile subgroups of ADHD. Sixty-two subjects from Healthy Brain Network Biobank of the Child Mind Institute dataset were selected basing on the quotient score. From both MRI and EEG asymmetry index, Pearson’s correlation, ANOVA, and partial least square analysis were performed matching left and right brain parcels and channels. The asymmetry index significantly correlated across subjects between fMRI and power-EEG in the inattention group in frontal and temporal areas for theta and alpha bands, an anticorrelation in the same areas for delta band was found. Significant patterns of hemispheric asymmetry index have been reported, involving EEG bands that underlie cognitive impairments in ADHD. Alpha and theta bands were altered in the inattention group of patients, reflecting widespread deficiency of basic attentional processing.

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“…These findings are not only interesting from a basic neuroscience point of view, but also in the context of clinical neuroscience ( Malatesta et al, 2021 ; Mundorf and Ocklenburg, 2021 ). Indeed, several neurodevelopmental and psychiatric disorders such as dyslexia ( Woodhead et al, 2021 ), schizophrenia ( Ocklenburg et al, 2013 ), ASD ( Floris and Howells, 2018 ), and ADHD ( Alperin et al, 2019 ) have been linked to altered functional as well as structural hemispheric asymmetries ( Mundorf and Ocklenburg, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective

Mundorf

Peterburs

Ocklenburg

2021

Front. Syst. Neurosci.

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Recent large-scale neuroimaging studies suggest that most parts of the human brain show structural differences between the left and the right hemisphere. Such structural hemispheric asymmetries have been reported for both cortical and subcortical structures. Interestingly, many neurodevelopmental and psychiatric disorders have been associated with altered functional hemispheric asymmetries. However, findings concerning the relation between structural hemispheric asymmetries and disorders have largely been inconsistent, both within specific disorders as well as between disorders. In the present review, we compare structural asymmetries from a clinical neuroscience perspective across different disorders. We focus especially on recent large-scale neuroimaging studies, to concentrate on replicable effects. With the notable exception of major depressive disorder, all reviewed disorders were associated with distinct patterns of alterations in structural hemispheric asymmetries. While autism spectrum disorder was associated with altered structural hemispheric asymmetries in a broader range of brain areas, most other disorders were linked to more specific alterations in brain areas related to cognitive functions that have been associated with the symptomology of these disorders. The implications of these findings are highlighted in the context of transdiagnostic approaches to psychopathology.

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The relationship between alpha asymmetry and ADHD depends on negative affect level and parenting practices

Cited by 22 publications

References 95 publications

Association Between Frontal Alpha Asymmetry With Cognitive Symptoms, Depression Severity, and Insomnia

Association Between Frontal Alpha Asymmetry With Cognitive Symptoms, Depression Severity, and Insomnia

Electroencephalographic and Neuroimaging Asymmetry Correlation in Patients with Attention-Deficit Hyperactivity Disorder

Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective

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