The Relationship between Anger Expression and Its Indices and Oral Lichen Planus

Mehdipour, Masoumeh; Zenouz, Ali Taghavi; Farnam, Alireza; Attaran, Rana; Farhang, Sara; Safarnavadeh, Maryam; Gholizadeh, Narges; Azari-Marhabi, Saranaz

doi:10.4068/cmj.2016.52.2.112

Cited by 13 publications

(9 citation statements)

References 13 publications

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“…Mehdipour et al . used the Anger Expression‐In scale to determine the correlation between anger and OLP, which showed the OLP group (MD = 69.42) reported greater anger than the control group (MD = 59.00, P = 0.005) 38 …”

Section: Resultsmentioning

confidence: 99%

Characteristics of the psychopathological status of oral lichen planus: a systematic review and meta‐analysis

Li¹,

He²,

Hua³

2022

Australian Dental Journal

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Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa having no clear aetiology or pathogenesis. The influence of psychological disturbances on OLP has been widely discussed but still bears the controversy. This study aimed at assessing scientific evidence between the OLP and psychological alterations of the patient. We searched seven important databases for studies on OLP and psychological factors (anxiety, depression, stress, sleep disorders, etc.) published between 1 January 2000, and 1 October 2020. Case‐control and cross‐sectional studies were incorporated into this study. The meta‐analysis used a random‐effects model assessed by using the I2 statistic. Dichotomous variables used the odds ratio and 95% confidence interval (CI), and continuous variables used the mean difference with 95% CI. Finally, 26 studies were included in the review. A meta‐analysis of 13 studies showed there was a significant association of OLP with anxiety, depression and stress compared with healthy controls. Certain personality characteristics and sleep disorders also influence the patient of OLP. Therefore, psychological and psychiatric examinations should be carried out routinely for patients with OLP and improve the prognosis of the disease. © 2022 Australian Dental Association

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Section: Resultsmentioning

confidence: 99%

Characteristics of the psychopathological status of oral lichen planus: a systematic review and meta‐analysis

Li¹,

He²,

Hua³

2022

Australian Dental Journal

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“… [69] While long term effects of these psychological disorders within the general population remains to be seen, it is of note that anger control has been correlated with OLP suppression. [70] Hence, one can include anger assessment in the COVID-19 patients as a part of prospective analysis.…”

Section: Discussion and Consequences Of The Hypothesismentioning

confidence: 99%

Rise and exacerbation of oral lichen planus in the background of SARS-CoV-2 infection

et al. 2021

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Oral Lichen Planus (OLP) is a chronic inflammatory disorder whose exact etiology remains unknown. Inflammatory mediators, cytotoxic CD8+ T cells and mast cells have been hypothesized to mediate the pathogenesis of OLP. COVID-19 pandemic caused by SARS-CoV-2 is marked by cytokine storms in the affected patients. Altered T-cell responses marked by exhaustion of T-cell count with hyperaggressive remaining T-cells and presence of cross-reactive antibodies render infected humans as fertile grounds for development of multisystem disorders. In addition, Vitamin D deficiency in COVID-19 patients can further modify the T cell mediated immunity. Increased circulating cytokines and hyperactive CD8+ T cells can alter the oral immune barriers rendering them susceptible to oral disorders. Due to the widespread immune dysregulation, it is possible that patients of COVID-19 may develop OLP in the aftermath or during recovery. The paper explores the pathogenic mechanism behind development OLP as post-COVID condition on account of their target receptor, T-cell responses, cytokine profile, mucosal immune barriers and nutrition deficiency.

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“…The SNS activation directly and indirectly releases epinephrine and norepinephrine through adrenal medulla [17]. Several studies have shown a positive and significant relationship between psychogenic stress and OLP [18][19][20][21], while others did not find a meaningful relationship [22,23]. The adrenergic receptors bind to the catecholamines secreted in response to stress, and lead to their effects in various cells of the body.…”

Section: Discussionmentioning

confidence: 99%

Full Upregulation of α1 and β1 adrenergic receptors as an effective factor on hyposalivation of patients with OLP

Gholizadeh¹,

Rezayi²,

Sheykhbahaei³

2019

Preprint

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Objectives: Oral lichen planus (OLP) is one of the common chronic, autoimmune disorders in oral cavity. Regarding the role of adrenergic receptors in mediating stress and that’s effect on salivary composition, the purpose of this study was to investigate salivary levels of α1- and β1-adrenergic receptors in OLP patients to response to this research question: Do agonist or antagonist of adrenergic receptors affect hyposalivation of OLP patients? Method: In this case-control study, stimulated and unstimulated saliva samples were collected from 33 patients and 33 healthy individuals. The salivary flow rate and levels of α1- and β1-adrenergic receptors were measured by ELISA assay. Data were analyzed using SPSS 25 and T-test. Results: The stimulated and unstimulated salivary flow rate was significantly lower in OLP patients than healthy subjects. The α1-adrenergic receptors in the unstimulated saliva of patients was significantly higher than in the healthy subjects (p<0.001). α1-receptor in unstimulated saliva in both groups of patients (p<0.001) and healthy subjects (p=0.006) was significantly higher than stimulated saliva in the same groups. The level of β1-adrenergic receptors in the patients was significantly higher in the unstimulated saliva (p=0.001) and lower in the stimulated saliva than in the healthy subjects (p=0.003). β1-receptor was significantly higher in the unstimulated saliva than stimulated saliva in the patients (p<0.001). Conclusion: high levels of α1- and β1-adrenergic receptors in saliva of OLP patients reduce salivary flow rate by increasing the salivary proteins, mucin and saliva viscosity. Selective antagonist of α1- and β1-adrenergic receptors Can improve hyposalivation of OLP patients. Keywords: Lichen Planus, Oral, Adrenergic Receptors, Adrenoceptors, saliva

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The Relationship between Anger Expression and Its Indices and Oral Lichen Planus

Cited by 13 publications

References 13 publications

Characteristics of the psychopathological status of oral lichen planus: a systematic review and meta‐analysis

Characteristics of the psychopathological status of oral lichen planus: a systematic review and meta‐analysis

Rise and exacerbation of oral lichen planus in the background of SARS-CoV-2 infection

Full Upregulation of α1 and β1 adrenergic receptors as an effective factor on hyposalivation of patients with OLP

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