The Relationship Between Antecedent Antibiotic Use and Resistance to Extended-Spectrum Cephalosporins in Group I  -Lactamase-Producing Organisms

Jacobson, Kalen; Cohen, Stuart H.; Inciardi, John F.; King, Jeff H.; Lippert, Werner; Iglesias, Teresa L.; VanCouwenberghe, Carolyn

doi:10.1093/clinids/21.5.1107

Cited by 147 publications

(102 citation statements)

References 25 publications

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“…These bacteria can produce a cephalosporinase that is able to inactivate most of the cephalosporins. 2,3 The majority of these bacteria are inducible Enterobacteriaceae (Enterobacter spp, Serratia spp, Citrobacter spp, Morganella morganii, Providencia spp, Proteus vulgaris, Pantoea agglomerans). The relationship between the emergence of resistance of group I ␤-lactamase-producing organisms and the prior use of extended-spectrum cephalosporins is now clearly proven.…”

Section: Introductionmentioning

confidence: 99%

“…The relationship between the emergence of resistance of group I ␤-lactamase-producing organisms and the prior use of extended-spectrum cephalosporins is now clearly proven. 2 Another risk factor of developing resistance to extended-spectrum cephalosporins is the amount of previously used antibiotics. 2 The clinical consequence is that development of resistance may become particularly devastating in neutropenic patients.…”

Section: Introductionmentioning

confidence: 99%

“…2 Another risk factor of developing resistance to extended-spectrum cephalosporins is the amount of previously used antibiotics. 2 The clinical consequence is that development of resistance may become particularly devastating in neutropenic patients. Chow et al 4 1991 that isolation of multiresistant Enterobacter sp in the initial blood culture was associated with a higher mortality rate than isolation of a more sensitive Enterobacter sp.…”

Section: Introductionmentioning

confidence: 99%

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Decreasing antibiotic resistance of Enterobacteriaceae by introducing a new antibiotic combination therapy for neutropenic fever patients

et al. 1998

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Prompt empiric antibiotic therapy is of critical importance for patients with neutropenic fever. However, a major concern with important clinical consequences is the emergence of bacterial resistance to antibiotics. After using ceftazidime with a glycopeptide as initial empiric therapy for neutropenic fever, we were confronted with a 75% reduced susceptibility rate to ceftazidime of inducible Enterobacteriaceae collected in 1994. The initial empiric therapy was therefore replaced in May 1995 by a combination of cefepime with amikacin, with addition of a glycopeptide after 48 h if necessary. After this change, we observed a significant decrease in reduced susceptibility of inducible Enterobacteriaceae, not only to ceftazidime, but also to amikacin, cotrimoxazole and ciprofloxacin. There was also a decrease in reduced susceptibility of non-inducible Enterobacteriaceae, such as Klebsiella spp, to ceftazidime. The reduction of resistance may be related at least in part to the combined use of cefepime together with an aminoglycoside. This study shows that it is possible to reverse bacterial resistance by modifying the antibiotic regimen used.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Decreasing antibiotic resistance of Enterobacteriaceae by introducing a new antibiotic combination therapy for neutropenic fever patients

et al. 1998

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“…The data on preventing this type of resistance by employing concomitant aminoglycoside therapy is mixed. Jacobson et al (1995) found a lower incidence of emergence of resistance to extended-spectrum cephalosporins among patients treated with concomitant aminoglycoside therapy, while Chow et al (1991) did not.…”

Section: Beta-lactams and Extended Spectrum Cephalosporinsmentioning

confidence: 90%

Resistance by Enterobacter spp. towards several antimicrobial drugs and heavy metals: A review

M¹,

Bagde²

2017

Afr. J. Biotechnol.

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Antimicrobial resistance developed in several pathogens poses an increasing threat to human health across the world. No country can escape from the medical and economic impacts from this serious problem. Although the antibiotic resistance is not a new phenomenon, the current magnitude and speed with which it is developing is a cause for the global concern including in India. There are so many common diseases resulting from the microorganisms such as blood stream infections, urinary tract infections, post-operative wound infections and intra-abdominal infections. In this review the antimicrobial susceptibility or resistance of Enterobacter towards antimicrobial agents and heavy metals, viz. ceftazidime, moxifloxacin, nalidixic acid, sulfamethaxazole, and nickel and lead is discussed briefly along with other antimicrobials and heavy metals. The mechanisms behind the resistance by Enterobacter was analyzed and evaluated by many workers after using currently employed susceptibility testing methods for Enterobacter spp. There are some factors influencing mode of action of fluoroquinolones, quinolones and sulfamethaxazole. History, classification, identification, clinical features and treatment of infections and the epidemiology of antimicrobials (drugs and heavy metals) resistance by the Enterobacter spp. is included in this review. Now a day, antimicrobial resistance is common in hospitals where acquired infections can be perilous. This situation compels scientists to synthesize new antibiotics and treatment modalities. Enterobacter causes nosocomial infections. It is ubiquitous and can survive on skin and dry surfaces and replicate in contaminated fluids. Numerous outbreaks have been described. Various mechanisms have been adapted by microorganisms to resist toxicity of antimicrobials. Antimicrobial drugs may be rendered inactive or ineffective by the major ways such as barrier to antibiotic entry into the bacterial cell, prevention of the antibiotic from reaching the target, often by extrusion, alteration of the target of the drug and inactivation of the antibiotic by modification or destruction. In addition, bacteria may be able to bypass the metabolic pathway affected by a particular drug or may be able to overproduce an enzyme that is inhibited by the drug action, more than one mechanism may operate at any given time

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“…26 Furthermore, micro-organisms detected in this study have been reported to cause nosocomial infection. 27,28 An antiseptic decontamination of the dental plaque with a 0.2% chlorhexidine gel decreased dental bacterial colonization and reduced the incidence of nosocomial infection in intensive care unit patients exposed to Operation duration (min)…”

Section: 10mentioning

confidence: 99%

Post-operative Infection by Pathogenic Micro-organisms in the Oral Cavity of Patients with Prostatic Carcinoma

Senpuku

Tada²,

Uehara

et al. 2006

J Int Med Res

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The aim of this study was to analyse the change in the oral cavity microflora of 14 patients who had undergone a radical prostatectomy for prostatic carcinoma. The detection of microorganisms in the oral cavity was compared before and after the surgical procedure.Post-operative infection, defined as those patients who had increased Candida species counts and/or pathogenic bacteria only at the postoperative examination, was observed in 10 patients. Six patients showed increased Candida species counts at the post-operative examination compared with the pre-operative examination. In five patients, pathogenic bacterial species were detected at the post-operative examination but not at the pre-operative examination. One patient had detectable pathogenic bacterial species only at the post-operative examination along with increased Candida species counts. Our findings suggest that pre-operative oral hygiene to remove bacterial and Candida species from patients who are scheduled for surgical procedures is important for satisfactory clinical outcomes.

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The Relationship Between Antecedent Antibiotic Use and Resistance to Extended-Spectrum Cephalosporins in Group I -Lactamase-Producing Organisms

Cited by 147 publications

References 25 publications

Decreasing antibiotic resistance of Enterobacteriaceae by introducing a new antibiotic combination therapy for neutropenic fever patients

Decreasing antibiotic resistance of Enterobacteriaceae by introducing a new antibiotic combination therapy for neutropenic fever patients

Resistance by Enterobacter spp. towards several antimicrobial drugs and heavy metals: A review

Post-operative Infection by Pathogenic Micro-organisms in the Oral Cavity of Patients with Prostatic Carcinoma

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