The relationship between anti-Müllerian hormone serum level and body mass index in a large cohort of infertile patients

Albu, Dragoş; Albu, Alice

doi:10.1007/s12020-018-1756-4

Cited by 35 publications

(34 citation statements)

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“…But in patients >35 years old, no correlation found in bivariate analysis or after adjustment for age in a multivariate linear regression model. However, the age of the patients was negatively associated with serum AMH level in all age groups after adjustment for BMI and this is the same we have in our study [24] .…”

Section: Discussionsupporting

confidence: 89%

Abdominal Myomectomy and Ovarian Reserve in Women at Child Bearing Period

Farag

Ahmed²

2020

The Medical Journal of Cairo University

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Background: Ovarian reserve is defined as the existent quantitative and qualitative follicular supply found in the ovaries which may turn into mature follicles and assigns a woman's reproductive potential. The commonly appointed tests of ovarian reserve can be divided into static markers (FSH, estradiol, inhibin-B and [AMH] Anti-Mullerian Hormone), dynamic markers (clomiphene citrate, gonadotrophins and gonadotrophin releasing hormone [GnRh] analogue stimulation tests) and ultrasonographic markers (Antral Follicle Count [AFC], ovarian volume and ovarian blood flow). Leiomyomas are the most common genital tract tumors of benign nature and the most frequent benign uterine disorder in women of reproductive period. Aim of Study: The study evaluated the effect of open myomectomy on ovarian reserve. From all ovarian reserve parameters, we use AFC and AMH to determine this effect due to their high specificity and sensitivity. Material and Methods: The study included 90 women in childbearing period with age ranging from 18 to 40 years old with negative pregnancy test and without surgical history of ovarian operation. AFC is determined by counting the number of follicles measuring (2-8mm) by TVS on cycle day 2 before the operation. While AMH is measured using blood sample to be determined by ELISA technique. Myomectomy was done postmenstrual. The 2 parameters were measured again 6 months postoperative with the same method before the operation to evaluate them as markers of ovarian reserve. The data we obtained was summarized, presented in tables and charts and analyzed in detailed methods by computerized system. Results: Our results found that, there were no significant changes in values of AMH and AFC after the operation (pvalue is 0.713 for AMH) (p-value is 0.252 for AFC). The correlation or relationship between values of AMH and AFC were studied. From recruited data and after detailed statistical analysis we found positive correlation between AMH and AFC before and after the operation. There was no significant effect of sites and types of myomas on ovarian reserve.

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Section: Discussionsupporting

confidence: 89%

Abdominal Myomectomy and Ovarian Reserve in Women at Child Bearing Period

Farag

Ahmed²

2020

The Medical Journal of Cairo University

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“…Albu reported that BMI was not significantly correlated with AMH in a cohort of infertile patients which was similar to our results. But when the association between AMH serum level and BMI was analyzed according to age group, AMH and BMI were positively correlated in young patients (≤ 30 years old and 30-35 years old, r = 0.139, p = 0.021 and r = 0.077, p = 0.027, respectively) [18]. However, Bernardi et al, reported that BMI at the age of 18 (β=-0.016; 95% CI -0.024, -0.008), which is considered the heaviest reported lifetime weight (β=-0.002; 95% CI -0.003, -0.001) was inversely associated with AMH.…”

Section: Discussionmentioning

confidence: 93%

The Relationship between Serum Levels of Anti-Mullerian Hormone and Body Mass Index in Adolescents with Polycystic Ovary Syndrome

Bakr¹,

Ghoneim²,

Tharwat³

2020

CROGR

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Introduction: Polycystic ovary syndrome is widely prevalent among adolescents and early diagnosis is crucial. While accurate diagnosis is not straightforward, anti-Mullerian hormone was found to be a reliable marker among young patients with polycystic ovary syndrome. However, its serum level was found to be affected by many other variables. This study assessed the relation between serum levels of anti-Mullerian hormone and body mass index in adolescents with polycystic ovary syndrome. Methods: This was a cross sectional analytical study, conducted at the Gynecology and Obstetrics outpatient clinics at Suez Canal University hospitals in Ismailia. It included 100 adolescents with PCOS who fulfilled the revised Rotterdam diagnostic criteria for PCOS, attending secondary stage or higher levels of education in Ismailia, Egypt. The recruited patients were divided into two groups. Group one reported to have BMI ≥ 30 and group two included those who have BMI < 30. Complete history taking, clinical examination (BMI) and biochemical markers including assessment of serum LH and AMH level, and ultrasound assessment to detect ovarian volume, antral follicular count, and presence of ovarian cysts. Results: AMH levels were not affected by BMI in adolescent patients with PCOS (r 0.19, p value 0.185). There were significant correlations between serum AMH and LH level, & between AMH and ovarian morphology among the studied population. The AMH was higher among those with menstrual irregularity and those with hyper-androginism. Accordingly, AMH level is not affected by patients' weight. Conclusion: The AMH was correlated to clinical and biochemical findings of PCOS.

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“…AMH levels have been observed to be higher in obese PCOS versus non-PCOS female adolescents of comparable age and puberty, and thus AMH level may be a useful biomarker for PCOS diagnosis in obese female adolescents (32). Additionally, there is increasing interest in a further putative role for AMH in the pathogenesis of PCOS, acting as an endocrine signal to directly increase gonadotropin-releasing hormone pulse (33,34). Limitation of our study include the need for larger numbers in both groups, i.e., PCOS and non-PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

Serum Anti-Müllerian Hormone Levels Were Negatively Associated With Body Fat Percentage in PCOS Patients

et al. 2021

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BackgroundObesity is a state of excess body fat accumulation, and appears to be closely associated with polycystic ovary syndrome (PCOS). Notably, plausible biological pathways through which obesity can regulate anti-Müllerian hormone (AMH) production have been proposed, and women with PCOS characteristically have an increased AMH level. Body fat accumulation can be described by body fat percentage (BFP). However, the relationship between BFP and AMH still remains unclear.Materials and MethodsA total of 87 controls and 156 PCOS patients were divided into lean and overweight/obese groups, and the PCOS patients were further divided into hyper-AMH and normal-AMH subgroups. Univariate regression was used to assess the unadjusted relationship between AMH and outcome variables, multivariable regression analysis was performed to test whether and how serum AMH levels were associated with BFP after adjusting for other co-variables. Receiver-operating characteristic (ROC) curve analyses were used to test the utility of BFP for the diagnosis of PCOS.ResultsBFP was higher in PCOS patients compared with controls, regardless of obesity. Serum AMH levels were negatively associated with BFP in the PCOS group (r = -0.371; P < 0.001) but not in the control group (r = -0.095; P = 0.385). Multivariable logistic regression analysis showed that elevated BFP was associated with a high risk of PCOS (odds ratio, 1.290; 95% confidence interval, 1.084–1.534, P = 0.004). Furthermore, the combination of BFP and serum AMH into a multivariate model gave an improved area under the curve (AUC) of 88.5%, with a sensitivity of 72.4% and specificity of 87.4%; the positive and negative predictive values were 91.2% and 63.9%, respectively. One limitation of this study is all the conclusion reported was based on small sample size.ConclusionsHerein, we described the negative correlation between BFP and serum AMH levels for the first time, and the present results highlight the importance of further investigation into the role of BFP, especially in body fat-related AMH change as it relates to the underlying pathogenesis of PCOS.

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The relationship between anti-Müllerian hormone serum level and body mass index in a large cohort of infertile patients

Cited by 35 publications

References 36 publications

Abdominal Myomectomy and Ovarian Reserve in Women at Child Bearing Period

Abdominal Myomectomy and Ovarian Reserve in Women at Child Bearing Period

The Relationship between Serum Levels of Anti-Mullerian Hormone and Body Mass Index in Adolescents with Polycystic Ovary Syndrome

Serum Anti-Müllerian Hormone Levels Were Negatively Associated With Body Fat Percentage in PCOS Patients

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