The Relationship Between Antioxidant Trace Elements (Zn-Cu and Se) and Oxidative Stress in Dogs Affected with Dermatophytosis

Abstract

Canine dermatologic problems are among the most common disorders seen in canine practice, caused by the fungus. The current study was planned to observe the relationship between antioxidant trace elements (Zn-Cu and Se) and oxidative stress in dogs affected with dermatophytosis. Briefly, this study comprised of 34 dogs. Compared different parameters including hematological, biochemical, histopathological, and the level of antioxidant trace elements in 14 infected dogs with 20 non-infected dogs (control group). Results showed a significantly higher level (P<0.05) of TLC (16.33x103 U/L), MCHC (34.65g/dL), RDW (18.25%), and lymphocyte (47.9%) in the dermatophytosis-infected dogs as compared to the control group. Similarly, serum biochemical findings revealed a significant elevation in cortisol level (709.88nmol/L) in infected dogs while a significant decrease in free T4 (8.57pmol/L) in infected dogs compared to the control group. Furthermore, the level of selenium (0.02±0.00mg/dL), copper (59.725±3.01mg/dL) and zinc (60.99±2.76mg/dL) were significantly lower (P=0.00) in dogs infected with dermatophytosis. The study revealed that dermatophytes infection represents a stress factor affecting the level of antioxidant trace elements and the antioxidant defense system of the infected animal.

Oxidative Stress Biomarkers and Lipid Profile During the Periparturient Period in Dromedary Camels With Ketosis

“…Pathological processes upset this balance ( Blázovics et al1992). The antioxidant system is composed of antioxidant enzymes including superoxide dismutase (SOD), CAT, and glutathione peroxidase, glutathione (GSH), ancillary enzymes (glutathione reductase and Stransferase, in addition to glucose 6-phosphate dehydrogenase), metal-binding proteins (ceruloplasmin, transferrin, and albumin), vitamins (ascorbate, alphatocopherol, and beta-carotene) in addition to flavonoids, and urate (Halliwell 1994;Abd Ellah et al 2007;El-Motaily et al 2022;Mahmood et al 2022). Under several diverse pathological conditions, free radicals generate tissue damage via the general mechanism of lipid peroxidation (Halliwell and Chirico 1993) Malondialdehyde (MDA) is the most extensively applied common biomarker used in biological and medical science for the assessment of lipoperoxidation (Bird and Draper 1994;Suttnar et al 2001;Salar-Amoli et al 2009;Li et al 2022).…”